ENSG00000137492

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260045 ENSG00000137492 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP12 protein_coding protein_coding 28.2351 6.758583 54.28828 0.2970931 1.315965 3.003981 5.657948 0.3649885 12.194887 0.2226421 1.4803866 5.024469 0.1530708 0.05203333 0.2262000 0.1741667 1.219063e-01 8.418996e-08 FALSE TRUE
ENST00000531878 ENSG00000137492 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP12 protein_coding processed_transcript 28.2351 6.758583 54.28828 0.2970931 1.315965 3.003981 4.618773 0.2403064 9.457978 0.1207759 0.7067667 5.241290 0.1303583 0.03720000 0.1750333 0.1378333 1.290288e-01 8.418996e-08   FALSE
ENST00000682527 ENSG00000137492 HEK293_OSMI2_2hA HEK293_TMG_2hB THAP12 protein_coding protein_coding 28.2351 6.758583 54.28828 0.2970931 1.315965 3.003981 14.410362 5.3685723 25.325629 0.3213609 2.4929581 2.235872 0.6033917 0.79350000 0.4648000 -0.3287000 8.418996e-08 8.418996e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137492 E001 0.4762024 0.2377182252 3.598694e-01 5.041833e-01 11 76349898 76349955 58 - 0.092 0.278 1.919
ENSG00000137492 E002 0.9544932 0.0711058873 4.660659e-03 1.498681e-02 11 76349956 76349963 8 - 0.092 0.658 3.905
ENSG00000137492 E003 1.0996659 0.0147017436 7.447266e-03 2.237901e-02 11 76349964 76349969 6 - 0.132 0.660 3.327
ENSG00000137492 E004 11.0110540 0.0016319427 4.751287e-04 2.064915e-03 11 76349970 76350012 43 - 0.841 1.296 1.661
ENSG00000137492 E005 42.2300586 0.0022494797 1.957127e-12 4.571223e-11 11 76350013 76350060 48 - 1.367 1.880 1.748
ENSG00000137492 E006 1437.3236115 0.0016105506 2.044701e-24 2.111808e-22 11 76350061 76352497 2437 - 2.970 3.139 0.562
ENSG00000137492 E007 151.3011722 0.0119880874 1.436681e-03 5.428624e-03 11 76352498 76352624 127 - 2.042 1.883 -0.533
ENSG00000137492 E008 102.6726517 0.0007223163 5.063926e-07 4.476230e-06 11 76352625 76352696 72 - 1.882 1.660 -0.750
ENSG00000137492 E009 122.4588736 0.0002778249 1.262565e-06 1.026166e-05 11 76352697 76352794 98 - 1.954 1.778 -0.593
ENSG00000137492 E010 1.7725263 0.0077909037 5.884483e-01 7.116351e-01 11 76355560 76355617 58 - 0.362 0.277 -0.546
ENSG00000137492 E011 110.5592492 0.0005943591 3.505648e-09 4.697846e-08 11 76355618 76355654 37 - 1.918 1.651 -0.902
ENSG00000137492 E012 2.5046162 0.0070781994 2.222487e-01 3.530970e-01 11 76355655 76359573 3919 - 0.384 0.660 1.329
ENSG00000137492 E013 142.4322130 0.0013457447 1.494073e-08 1.783427e-07 11 76360956 76361063 108 - 2.023 1.803 -0.740
ENSG00000137492 E014 5.5020531 0.0288636261 3.793883e-01 5.236498e-01 11 76361064 76361369 306 - 0.692 0.567 -0.544
ENSG00000137492 E015 3.5431918 0.0247424874 1.997383e-02 5.142747e-02 11 76362882 76362975 94 - 0.585 0.000 -11.425
ENSG00000137492 E016 52.8363183 0.0004196533 1.497103e-04 7.457645e-04 11 76364338 76364432 95 - 1.600 1.368 -0.796
ENSG00000137492 E017 4.8508383 0.0035241270 8.725213e-01 9.220073e-01 11 76364641 76364720 80 - 0.635 0.660 0.106
ENSG00000137492 E018 7.6319642 0.0291011670 6.877021e-03 2.090416e-02 11 76365320 76365779 460 - 0.841 0.278 -2.728
ENSG00000137492 E019 4.9125791 0.0070161846 1.757744e-01 2.956971e-01 11 76365780 76365851 72 - 0.670 0.445 -1.041
ENSG00000137492 E020 105.0838778 0.0003484971 7.002110e-08 7.325246e-07 11 76365852 76365972 121 - 1.895 1.659 -0.796
ENSG00000137492 E021 0.0000000       11 76368566 76368643 78 -      
ENSG00000137492 E022 0.2924217 0.0272532016 1.000000e+00   11 76380537 76380628 92 - 0.092 0.000 -7.927
ENSG00000137492 E023 48.4875328 0.0020728692 1.481647e-05 9.468498e-05 11 76380748 76381132 385 - 1.571 1.254 -1.097