ENSG00000137449

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345451 ENSG00000137449 HEK293_OSMI2_2hA HEK293_TMG_2hB CPEB2 protein_coding protein_coding 1.293333 0.4516802 2.492436 0.05526259 0.2289772 2.438368 0.61422895 0.38493447 1.24131950 0.04262174 0.04314407 1.663765 0.52193750 0.8545 0.50363333 -0.35086667 0.0020678584 0.0009562944 FALSE TRUE
ENST00000382401 ENSG00000137449 HEK293_OSMI2_2hA HEK293_TMG_2hB CPEB2 protein_coding protein_coding 1.293333 0.4516802 2.492436 0.05526259 0.2289772 2.438368 0.08620537 0.00000000 0.15344597 0.00000000 0.07751093 4.030742 0.08775417 0.0000 0.06346667 0.06346667 0.6287061561 0.0009562944 FALSE TRUE
ENST00000507071 ENSG00000137449 HEK293_OSMI2_2hA HEK293_TMG_2hB CPEB2 protein_coding protein_coding 1.293333 0.4516802 2.492436 0.05526259 0.2289772 2.438368 0.07747628 0.02011202 0.02590103 0.02011202 0.02590103 0.253686 0.09605417 0.0520 0.00890000 -0.04310000 0.6551924334 0.0009562944 FALSE TRUE
ENST00000509684 ENSG00000137449 HEK293_OSMI2_2hA HEK293_TMG_2hB CPEB2 protein_coding protein_coding 1.293333 0.4516802 2.492436 0.05526259 0.2289772 2.438368 0.29212774 0.00000000 0.73251287 0.00000000 0.18113095 6.214344 0.14748750 0.0000 0.28600000 0.28600000 0.0009562944 0.0009562944 FALSE FALSE
ENST00000538197 ENSG00000137449 HEK293_OSMI2_2hA HEK293_TMG_2hB CPEB2 protein_coding protein_coding 1.293333 0.4516802 2.492436 0.05526259 0.2289772 2.438368 0.14758474 0.04663375 0.33925710 0.02705246 0.03826924 2.624555 0.10420833 0.0935 0.13800000 0.04450000 0.8202901551 0.0009562944 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137449 E001 2.4464415 0.0063310784 3.894658e-01 5.335469e-01 4 15002481 15002673 193 + 0.522 0.357 -0.872
ENSG00000137449 E002 14.4142862 0.0131222677 7.005302e-02 1.434553e-01 4 15002674 15004335 1662 + 1.165 0.938 -0.831
ENSG00000137449 E003 6.3462563 0.0154720961 2.976158e-01 4.389685e-01 4 15007305 15007366 62 + 0.844 0.682 -0.651
ENSG00000137449 E004 18.5917259 0.0009906508 1.331704e-01 2.385515e-01 4 15007367 15007586 220 + 1.259 1.117 -0.503
ENSG00000137449 E005 0.8857980 0.0136968632 2.038690e-01 3.310394e-01 4 15007587 15007595 9 + 0.301 0.000 -10.328
ENSG00000137449 E006 2.5109720 0.0061140579 6.854102e-01 7.881612e-01 4 15008338 15008427 90 + 0.477 0.550 0.351
ENSG00000137449 E007 10.9418751 0.0237705659 1.207777e-01 2.210615e-01 4 15017188 15017278 91 + 1.060 0.828 -0.872
ENSG00000137449 E008 0.0000000       4 15017279 15017434 156 +      
ENSG00000137449 E009 9.3583288 0.0313411585 9.384791e-02 1.811414e-01 4 15033161 15033211 51 + 1.007 0.736 -1.042
ENSG00000137449 E010 0.8878743 0.0132348006 2.032785e-01 3.303079e-01 4 15040464 15040487 24 + 0.301 0.000 -10.329
ENSG00000137449 E011 13.8281184 0.0014953351 9.383096e-01 9.652473e-01 4 15052414 15052584 171 + 1.108 1.117 0.033
ENSG00000137449 E012 5.1523419 0.0079011399 6.343244e-01 7.488120e-01 4 15054128 15054132 5 + 0.713 0.785 0.293
ENSG00000137449 E013 10.5710943 0.0065978141 4.121702e-01 5.557173e-01 4 15054133 15054217 85 + 0.977 1.073 0.351
ENSG00000137449 E014 13.1265686 0.0013616513 9.290530e-01 9.593977e-01 4 15058421 15058539 119 + 1.085 1.095 0.039
ENSG00000137449 E015 13.0736845 0.0014831004 8.580434e-03 2.523970e-02 4 15059187 15059301 115 + 1.146 0.828 -1.181
ENSG00000137449 E016 16.0842662 0.0014359694 1.274097e-01 2.305407e-01 4 15062079 15062260 182 + 1.204 1.048 -0.557
ENSG00000137449 E017 0.5911862 0.0193874923 3.991989e-01 5.429388e-01 4 15063738 15063871 134 + 0.222 0.000 -9.817
ENSG00000137449 E018 128.6557844 0.0015552019 2.717957e-06 2.054376e-05 4 15066153 15070153 4001 + 2.015 2.140 0.418