ENSG00000137434

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379586 ENSG00000137434 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf52 protein_coding protein_coding 4.975365 7.801831 4.96813 0.5387602 0.7551674 -0.6500568 0.1336811 0.0000000 0.53006515 0.0000000 0.13884607 5.7550616 0.03097083 0.00000000 0.11090000 0.110900000 8.376393e-08 8.376393e-08 FALSE FALSE
ENST00000426700 ENSG00000137434 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf52 protein_coding protein_coding 4.975365 7.801831 4.96813 0.5387602 0.7551674 -0.6500568 0.2089876 0.1042310 0.00000000 0.1042310 0.00000000 -3.5138825 0.05600417 0.01550000 0.00000000 -0.015500000 8.609762e-01 8.376393e-08 FALSE TRUE
ENST00000460742 ENSG00000137434 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf52 protein_coding protein_coding 4.975365 7.801831 4.96813 0.5387602 0.7551674 -0.6500568 0.7423587 1.4991997 0.63835837 0.4430854 0.25126900 -1.2189204 0.14401250 0.19946667 0.12900000 -0.070466667 7.365137e-01 8.376393e-08 TRUE FALSE
MSTRG.27637.1 ENSG00000137434 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf52 protein_coding   4.975365 7.801831 4.96813 0.5387602 0.7551674 -0.6500568 0.5447084 0.1560211 0.07827103 0.1560211 0.07827103 -0.9113545 0.12167083 0.02320000 0.01586667 -0.007333333 9.796486e-01 8.376393e-08   FALSE
MSTRG.27637.10 ENSG00000137434 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf52 protein_coding   4.975365 7.801831 4.96813 0.5387602 0.7551674 -0.6500568 0.4553684 0.5441092 0.86594535 0.2741227 0.32193108 0.6606705 0.08374167 0.06523333 0.16183333 0.096600000 5.574209e-01 8.376393e-08   FALSE
MSTRG.27637.13 ENSG00000137434 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf52 protein_coding   4.975365 7.801831 4.96813 0.5387602 0.7551674 -0.6500568 0.6037796 1.0658084 0.82205739 0.4361810 0.10379090 -0.3706662 0.13111667 0.13470000 0.17580000 0.041100000 7.770494e-01 8.376393e-08 FALSE TRUE
MSTRG.27637.8 ENSG00000137434 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf52 protein_coding   4.975365 7.801831 4.96813 0.5387602 0.7551674 -0.6500568 1.4288705 3.2429117 1.06597621 0.4964902 0.15868640 -1.5960855 0.27352500 0.41080000 0.21813333 -0.192666667 7.032150e-03 8.376393e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137434 E001 0.2924217 0.0290785164 0.09310366   6 10671418 10671421 4 - 0.267 0.000 -9.966
ENSG00000137434 E002 0.4407149 0.0217681645 0.30301082 0.44492879 6 10671422 10671429 8 - 0.267 0.096 -1.776
ENSG00000137434 E003 0.7331366 0.0159634799 0.05155192 0.11190881 6 10671430 10671431 2 - 0.432 0.096 -2.775
ENSG00000137434 E004 3.5625641 0.0048111291 0.03736392 0.08615485 6 10671432 10671432 1 - 0.815 0.511 -1.304
ENSG00000137434 E005 5.0363234 0.0037640927 0.01817566 0.04750985 6 10671433 10671445 13 - 0.937 0.627 -1.243
ENSG00000137434 E006 32.1850618 0.0007227273 0.94876798 0.97189477 6 10671446 10671598 153 - 1.500 1.496 -0.014
ENSG00000137434 E007 9.0543137 0.0020707430 0.02253362 0.05678955 6 10672547 10672636 90 - 1.125 0.888 -0.877
ENSG00000137434 E008 29.8651764 0.0009006728 0.75593588 0.84113889 6 10683187 10683232 46 - 1.482 1.464 -0.063
ENSG00000137434 E009 5.5741842 0.2060461275 0.84248764 0.90186047 6 10684849 10684923 75 - 0.814 0.780 -0.136
ENSG00000137434 E010 30.3687221 0.0046947354 0.68263434 0.78604355 6 10686966 10687056 91 - 1.457 1.487 0.103
ENSG00000137434 E011 29.6286473 0.0009634055 0.07385340 0.14967325 6 10687057 10687146 90 - 1.387 1.500 0.386
ENSG00000137434 E012 13.6264532 0.0066371280 0.28201849 0.42198195 6 10687147 10687164 18 - 1.066 1.168 0.366
ENSG00000137434 E013 3.0121760 0.0057822938 0.52200077 0.65587908 6 10687480 10687561 82 - 0.644 0.543 -0.451
ENSG00000137434 E014 22.6270718 0.0084748517 0.08059047 0.16047365 6 10694494 10694624 131 - 1.245 1.384 0.486
ENSG00000137434 E015 2.9828288 0.0054637744 0.75713248 0.84205726 6 10694625 10694702 78 - 0.551 0.600 0.225
ENSG00000137434 E016 2.3979749 0.0068888550 0.79939354 0.87203297 6 10694703 10694809 107 - 0.551 0.510 -0.191