ENSG00000137413

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372977 ENSG00000137413 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF8 protein_coding protein_coding 15.98809 21.54417 13.90543 1.659227 0.5951313 -0.6312819 3.5193907 4.0482664 3.2668919 0.33413200 0.16127300 -0.3085355 0.22365833 0.18863333 0.23530000 0.04666667 2.768337e-01 1.805805e-26 FALSE TRUE
ENST00000372978 ENSG00000137413 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF8 protein_coding protein_coding 15.98809 21.54417 13.90543 1.659227 0.5951313 -0.6312819 5.6339676 11.6543591 2.5108627 1.12656525 0.16890409 -2.2101176 0.33107083 0.53933333 0.18086667 -0.35846667 1.805805e-26 1.805805e-26 FALSE TRUE
ENST00000456846 ENSG00000137413 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF8 protein_coding protein_coding 15.98809 21.54417 13.90543 1.659227 0.5951313 -0.6312819 0.9217636 1.2943574 0.7378552 0.21636588 0.01488637 -0.8025084 0.05777500 0.05940000 0.05330000 -0.00610000 8.294742e-01 1.805805e-26 FALSE TRUE
ENST00000494547 ENSG00000137413 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF8 protein_coding protein_coding 15.98809 21.54417 13.90543 1.659227 0.5951313 -0.6312819 1.1589860 0.1208381 0.9400125 0.12083807 0.19506578 2.8601641 0.07802917 0.00490000 0.06773333 0.06283333 2.001589e-02 1.805805e-26 FALSE TRUE
ENST00000688007 ENSG00000137413 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF8 protein_coding protein_coding 15.98809 21.54417 13.90543 1.659227 0.5951313 -0.6312819 1.5960805 1.8641958 2.3070416 0.13877321 0.17795161 0.3060122 0.10247500 0.08836667 0.16706667 0.07870000 3.273278e-02 1.805805e-26 FALSE TRUE
MSTRG.28285.7 ENSG00000137413 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF8 protein_coding   15.98809 21.54417 13.90543 1.659227 0.5951313 -0.6312819 1.1343654 0.4850375 2.3332819 0.05005969 0.33572240 2.2429208 0.07583750 0.02246667 0.16633333 0.14386667 1.057185e-15 1.805805e-26 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137413 E001 0.1817044 0.0424203683 6.283494e-01   6 42050513 42050519 7 + 0.000 0.108 10.686
ENSG00000137413 E002 0.1817044 0.0424203683 6.283494e-01   6 42050520 42050521 2 + 0.000 0.108 12.414
ENSG00000137413 E003 0.1817044 0.0424203683 6.283494e-01   6 42050522 42050523 2 + 0.000 0.108 12.414
ENSG00000137413 E004 0.1817044 0.0424203683 6.283494e-01   6 42050524 42050530 7 + 0.000 0.108 12.414
ENSG00000137413 E005 0.1817044 0.0424203683 6.283494e-01   6 42050531 42050533 3 + 0.000 0.108 12.414
ENSG00000137413 E006 2.6111173 0.0699678942 2.474001e-01 3.828903e-01 6 42050534 42050538 5 + 0.678 0.469 -0.953
ENSG00000137413 E007 65.8782272 0.0005574860 9.309648e-02 1.799678e-01 6 42050539 42050586 48 + 1.763 1.842 0.269
ENSG00000137413 E008 0.2214452 0.0432543428 6.277213e-01   6 42050587 42050629 43 + 0.000 0.108 12.409
ENSG00000137413 E009 0.5848540 0.1178207629 1.518815e-01 2.642335e-01 6 42050630 42050875 246 + 0.000 0.268 13.589
ENSG00000137413 E010 0.3634088 0.4827280456 4.115182e-01   6 42050876 42050923 48 + 0.000 0.195 12.518
ENSG00000137413 E011 1.0600373 0.8975824169 7.006500e-01 8.000726e-01 6 42050924 42050994 71 + 0.140 0.385 1.914
ENSG00000137413 E012 3.0328157 0.2900356940 5.308405e-01 6.633694e-01 6 42050995 42051151 157 + 0.677 0.545 -0.578
ENSG00000137413 E013 0.2924217 0.0290785164 1.335268e-01   6 42051152 42051356 205 + 0.244 0.000 -14.845
ENSG00000137413 E014 139.6647178 0.0004797593 4.195907e-04 1.849470e-03 6 42051357 42051513 157 + 2.064 2.179 0.384
ENSG00000137413 E015 0.3697384 0.0247295755 2.938912e-01 4.349479e-01 6 42051514 42051780 267 + 0.000 0.194 13.594
ENSG00000137413 E016 131.0185536 0.0003860276 1.897107e-04 9.200084e-04 6 42055531 42055629 99 + 2.032 2.156 0.417
ENSG00000137413 E017 103.6751529 0.0006238279 1.006134e-03 3.979644e-03 6 42055952 42056014 63 + 1.933 2.059 0.422
ENSG00000137413 E018 3.5226434 0.0250569073 9.591861e-02 1.842633e-01 6 42056015 42057388 1374 + 0.460 0.739 1.252
ENSG00000137413 E019 132.8950023 0.0002478573 6.977798e-04 2.891055e-03 6 42057389 42057513 125 + 2.048 2.159 0.371
ENSG00000137413 E020 53.0935032 0.0006761934 1.056111e-29 1.735273e-27 6 42057514 42057789 276 + 1.196 1.890 2.382
ENSG00000137413 E021 6.8365880 0.0043264398 2.416992e-02 6.015711e-02 6 42063186 42064086 901 + 0.678 0.975 1.162
ENSG00000137413 E022 81.1490547 0.0003741911 1.552790e-10 2.652104e-09 6 42066312 42066459 148 + 2.038 1.796 -0.813
ENSG00000137413 E023 12.9298308 0.0314145241 9.480646e-01 9.713686e-01 6 42066460 42068304 1845 + 1.140 1.127 -0.045
ENSG00000137413 E024 49.5498811 0.0005358032 7.667648e-07 6.531827e-06 6 42068465 42068503 39 + 1.826 1.587 -0.808
ENSG00000137413 E025 73.3062520 0.0009798591 2.801941e-11 5.424272e-10 6 42068504 42068607 104 + 2.012 1.735 -0.931
ENSG00000137413 E026 1.6813993 0.0983972949 8.613810e-01 9.145816e-01 6 42068725 42068905 181 + 0.399 0.431 0.172
ENSG00000137413 E027 5.0908627 0.0730589224 7.765592e-01 8.561167e-01 6 42071347 42071468 122 + 0.798 0.745 -0.211
ENSG00000137413 E028 1.2491896 0.3813263904 6.628655e-02 1.371971e-01 6 42072907 42073030 124 + 0.000 0.448 14.227
ENSG00000137413 E029 79.7885934 0.0021419256 2.515959e-11 4.910280e-10 6 42077100 42077239 140 + 2.054 1.767 -0.967
ENSG00000137413 E030 93.0252765 0.0003548725 2.544981e-08 2.906203e-07 6 42077533 42077857 325 + 2.073 1.876 -0.659
ENSG00000137413 E031 153.2425589 0.0002901522 4.826659e-08 5.222435e-07 6 42077858 42078465 608 + 2.264 2.116 -0.494
ENSG00000137413 E032 297.3351477 0.0013101866 6.826660e-01 7.860704e-01 6 42078466 42079735 1270 + 2.456 2.470 0.048
ENSG00000137413 E033 19.8995549 0.0184300014 1.060375e-01 1.996650e-01 6 42079736 42079738 3 + 1.195 1.362 0.583
ENSG00000137413 E034 393.9224396 0.0012965069 3.096806e-02 7.385297e-02 6 42079739 42083272 3534 + 2.554 2.606 0.172
ENSG00000137413 E035 9.9159169 0.0017750603 7.099377e-01 8.071863e-01 6 42085893 42086200 308 + 1.002 1.046 0.162
ENSG00000137413 E036 21.2307715 0.0012097148 5.913370e-05 3.271817e-04 6 42086719 42087461 743 + 1.116 1.446 1.160