ENSG00000137364

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309983 ENSG00000137364 HEK293_OSMI2_2hA HEK293_TMG_2hB TPMT protein_coding protein_coding 21.82122 8.446272 36.29537 0.5674944 0.7026176 2.102089 6.538247 3.6888919 10.405108 0.6211732 0.45445488 1.493513 0.3370625 0.43113333 0.2864000 -0.14473333 0.03670666 0.03670666 FALSE TRUE
MSTRG.27698.2 ENSG00000137364 HEK293_OSMI2_2hA HEK293_TMG_2hB TPMT protein_coding   21.82122 8.446272 36.29537 0.5674944 0.7026176 2.102089 5.246672 1.5503273 7.896620 0.6313463 0.40530343 2.341212 0.2228333 0.18083333 0.2176667 0.03683333 0.74761490 0.03670666 FALSE TRUE
MSTRG.27698.3 ENSG00000137364 HEK293_OSMI2_2hA HEK293_TMG_2hB TPMT protein_coding   21.82122 8.446272 36.29537 0.5674944 0.7026176 2.102089 5.549351 2.2546803 10.313796 0.5015414 0.08590735 2.188594 0.2517458 0.27313333 0.2844333 0.01130000 0.93237542 0.03670666 FALSE TRUE
MSTRG.27698.6 ENSG00000137364 HEK293_OSMI2_2hA HEK293_TMG_2hB TPMT protein_coding   21.82122 8.446272 36.29537 0.5674944 0.7026176 2.102089 3.478635 0.5009799 6.422986 0.2992140 0.68183954 3.654150 0.1427167 0.06356667 0.1764000 0.11283333 0.33449585 0.03670666 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137364 E001 255.918706 0.0064888049 0.0014709334 0.005542242 6 18128311 18130107 1797 - 2.313 2.462 0.496
ENSG00000137364 E002 120.869110 0.0003734280 0.0008277153 0.003358424 6 18130108 18130371 264 - 1.998 2.125 0.426
ENSG00000137364 E003 81.821873 0.0047109498 0.0523103007 0.113271825 6 18130372 18130425 54 - 1.833 1.946 0.380
ENSG00000137364 E004 271.633643 0.0009281339 0.0538570498 0.116001825 6 18130426 18130780 355 - 2.366 2.425 0.197
ENSG00000137364 E005 150.863998 0.0002895489 0.3096540727 0.451991210 6 18132133 18132177 45 - 2.135 2.111 -0.080
ENSG00000137364 E006 151.537136 0.0002279768 0.4674133014 0.606910397 6 18133804 18133889 86 - 2.134 2.119 -0.048
ENSG00000137364 E007 162.937962 0.0004979354 0.5928183069 0.715289789 6 18138963 18139037 75 - 2.165 2.157 -0.026
ENSG00000137364 E008 0.894217 0.0136514540 0.1566540622 0.270647394 6 18139661 18139664 4 - 0.315 0.001 -9.364
ENSG00000137364 E009 151.992788 0.0013781980 0.9126724543 0.948656369 6 18139665 18139717 53 - 2.131 2.135 0.013
ENSG00000137364 E010 244.627187 0.0023362301 0.4586281925 0.598943475 6 18143596 18143728 133 - 2.341 2.323 -0.060
ENSG00000137364 E011 206.375923 0.0002200447 0.4377684266 0.579657486 6 18147823 18147915 93 - 2.266 2.254 -0.041
ENSG00000137364 E012 198.182325 0.0002355466 0.0006273895 0.002633543 6 18148988 18149076 89 - 2.269 2.178 -0.303
ENSG00000137364 E013 161.123548 0.0035479862 0.0009300051 0.003719373 6 18149077 18149171 95 - 2.188 2.051 -0.457
ENSG00000137364 E014 4.030946 0.0110125170 0.2838607347 0.424058579 6 18150359 18150653 295 - 0.706 0.529 -0.777
ENSG00000137364 E015 93.340597 0.0042084197 0.0043046087 0.013997034 6 18155033 18155147 115 - 1.956 1.808 -0.497