ENSG00000137337

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376406 ENSG00000137337 HEK293_OSMI2_2hA HEK293_TMG_2hB MDC1 protein_coding protein_coding 50.87679 64.18968 43.03509 2.213682 1.261805 -0.5767174 24.8898549 28.136259 23.764200 2.2285413 0.98643508 -0.2435464 0.50276667 0.43813333 0.55216667 0.11403333 7.721260e-02 2.056902e-31 FALSE TRUE
ENST00000416571 ENSG00000137337 HEK293_OSMI2_2hA HEK293_TMG_2hB MDC1 protein_coding protein_coding 50.87679 64.18968 43.03509 2.213682 1.261805 -0.5767174 0.6442142 0.000000 2.267938 0.0000000 1.27531459 7.8315846 0.01481250 0.00000000 0.05113333 0.05113333 1.480538e-01 2.056902e-31 FALSE FALSE
ENST00000489540 ENSG00000137337 HEK293_OSMI2_2hA HEK293_TMG_2hB MDC1 protein_coding retained_intron 50.87679 64.18968 43.03509 2.213682 1.261805 -0.5767174 7.8642990 21.732639 0.518027 2.9463948 0.03461056 -5.3637715 0.13015833 0.33950000 0.01210000 -0.32740000 5.056355e-26 2.056902e-31 TRUE TRUE
MSTRG.27993.52 ENSG00000137337 HEK293_OSMI2_2hA HEK293_TMG_2hB MDC1 protein_coding   50.87679 64.18968 43.03509 2.213682 1.261805 -0.5767174 2.3601177 5.772163 0.000000 0.7951408 0.00000000 -9.1754654 0.03747500 0.08933333 0.00000000 -0.08933333 2.056902e-31 2.056902e-31 FALSE TRUE
MSTRG.27993.58 ENSG00000137337 HEK293_OSMI2_2hA HEK293_TMG_2hB MDC1 protein_coding   50.87679 64.18968 43.03509 2.213682 1.261805 -0.5767174 1.8479669 1.044517 2.855569 0.3878312 0.45433247 1.4422394 0.04074167 0.01623333 0.06706667 0.05083333 9.542735e-03 2.056902e-31 FALSE TRUE
MSTRG.27993.80 ENSG00000137337 HEK293_OSMI2_2hA HEK293_TMG_2hB MDC1 protein_coding   50.87679 64.18968 43.03509 2.213682 1.261805 -0.5767174 1.3736198 0.000000 2.674247 0.0000000 1.35315289 8.0683736 0.02831250 0.00000000 0.06163333 0.06163333 1.475135e-01 2.056902e-31 FALSE TRUE
MSTRG.27993.9 ENSG00000137337 HEK293_OSMI2_2hA HEK293_TMG_2hB MDC1 protein_coding   50.87679 64.18968 43.03509 2.213682 1.261805 -0.5767174 1.0341347 0.000000 2.519492 0.0000000 1.62568832 7.9827040 0.02487083 0.00000000 0.05966667 0.05966667 1.614003e-01 2.056902e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137337 E001 531.848121 0.0046804636 1.365022e-29 2.208363e-27 6 30699807 30700058 252 - 2.387 2.829 1.472
ENSG00000137337 E002 433.681867 0.0043116633 4.775429e-33 1.000764e-30 6 30700059 30700149 91 - 2.276 2.745 1.564
ENSG00000137337 E003 206.492385 0.0009624071 9.914192e-42 3.848799e-39 6 30700150 30700150 1 - 1.971 2.419 1.499
ENSG00000137337 E004 231.341861 0.0002871053 1.463721e-61 1.584558e-58 6 30700151 30700173 23 - 1.993 2.472 1.600
ENSG00000137337 E005 217.409913 0.0002006233 3.334218e-68 4.644541e-65 6 30700174 30700185 12 - 1.929 2.450 1.742
ENSG00000137337 E006 205.970024 0.0002288561 3.708242e-77 7.096115e-74 6 30700186 30700210 25 - 1.852 2.438 1.961
ENSG00000137337 E007 154.288679 0.0009971414 1.077831e-52 7.663203e-50 6 30700211 30700211 1 - 1.715 2.316 2.018
ENSG00000137337 E008 200.405780 0.0028335466 5.312962e-51 3.423553e-48 6 30700212 30700256 45 - 1.789 2.433 2.160
ENSG00000137337 E009 204.144601 0.0178150013 5.081868e-14 1.507350e-12 6 30700257 30700293 37 - 1.868 2.433 1.890
ENSG00000137337 E010 152.646842 0.0188888541 8.508875e-11 1.520306e-09 6 30700294 30700296 3 - 1.789 2.299 1.711
ENSG00000137337 E011 153.573051 0.0155036848 1.315138e-11 2.686822e-10 6 30700297 30700297 1 - 1.807 2.299 1.647
ENSG00000137337 E012 153.687946 0.0151982756 8.856081e-12 1.861074e-10 6 30700298 30700298 1 - 1.807 2.299 1.648
ENSG00000137337 E013 187.382863 0.0267435445 3.717095e-08 4.109433e-07 6 30700299 30700311 13 - 1.899 2.384 1.624
ENSG00000137337 E014 180.238349 0.0228239970 8.565456e-07 7.217453e-06 6 30700312 30700314 3 - 1.949 2.353 1.354
ENSG00000137337 E015 874.739915 0.0087931072 6.626952e-09 8.447424e-08 6 30700315 30700632 318 - 2.729 3.013 0.945
ENSG00000137337 E016 521.325283 0.0025686292 2.574402e-15 9.231738e-14 6 30702553 30702663 111 - 2.533 2.778 0.815
ENSG00000137337 E017 545.520051 0.0008448432 8.764879e-29 1.324147e-26 6 30702752 30702877 126 - 2.550 2.797 0.824
ENSG00000137337 E018 586.293409 0.0013488057 3.219490e-27 4.244417e-25 6 30703104 30703286 183 - 2.567 2.833 0.885
ENSG00000137337 E019 506.048075 0.0016811128 9.754096e-18 4.802194e-16 6 30703418 30703537 120 - 2.528 2.761 0.776
ENSG00000137337 E020 5.784227 0.0057391481 1.996013e-01 3.257289e-01 6 30703538 30703620 83 - 0.686 0.865 0.718
ENSG00000137337 E021 1152.398239 0.0006334308 4.484710e-11 8.388773e-10 6 30703621 30704183 563 - 2.972 3.083 0.371
ENSG00000137337 E022 320.154429 0.0005026292 8.210157e-01 8.871749e-01 6 30704184 30704251 68 - 2.480 2.491 0.037
ENSG00000137337 E023 195.255009 0.0016383930 1.132607e-01 2.102813e-01 6 30704252 30704266 15 - 2.300 2.256 -0.148
ENSG00000137337 E024 339.712667 0.0003868000 4.244535e-04 1.868122e-03 6 30704267 30704374 108 - 2.556 2.487 -0.232
ENSG00000137337 E025 150.869738 0.0026216737 1.682563e-02 4.454459e-02 6 30704375 30704389 15 - 2.216 2.131 -0.284
ENSG00000137337 E026 308.598883 0.0017382385 3.525610e-02 8.213937e-02 6 30704390 30704497 108 - 2.508 2.454 -0.179
ENSG00000137337 E027 253.702512 0.0005358578 3.789302e-09 5.046905e-08 6 30704498 30704568 71 - 2.470 2.329 -0.468
ENSG00000137337 E028 178.232800 0.0017314410 4.552532e-15 1.576716e-13 6 30704569 30704620 52 - 2.378 2.124 -0.849
ENSG00000137337 E029 275.151345 0.0010993640 6.331930e-11 1.153983e-09 6 30704621 30704691 71 - 2.519 2.352 -0.559
ENSG00000137337 E030 262.360038 0.0001775107 2.723918e-12 6.231591e-11 6 30704692 30704766 75 - 2.491 2.339 -0.509
ENSG00000137337 E031 299.305250 0.0001534325 1.885885e-16 7.840142e-15 6 30704767 30704866 100 - 2.558 2.390 -0.560
ENSG00000137337 E032 367.695623 0.0001695218 2.462889e-10 4.059395e-09 6 30704867 30705012 146 - 2.619 2.502 -0.390
ENSG00000137337 E033 292.116235 0.0003116095 1.860552e-06 1.457838e-05 6 30705013 30705112 100 - 2.509 2.408 -0.337
ENSG00000137337 E034 314.192700 0.0004572243 7.347392e-16 2.825703e-14 6 30705113 30705235 123 - 2.582 2.409 -0.579
ENSG00000137337 E035 269.366063 0.0009645186 3.174192e-25 3.539382e-23 6 30705236 30705381 146 - 2.563 2.298 -0.882
ENSG00000137337 E036 179.749580 0.0021246454 2.169140e-14 6.791226e-13 6 30705382 30705447 66 - 2.383 2.125 -0.860
ENSG00000137337 E037 136.008136 0.0056495327 2.040856e-08 2.376069e-07 6 30705448 30705481 34 - 2.263 2.005 -0.862
ENSG00000137337 E038 129.833362 0.0055722102 5.196214e-08 5.584338e-07 6 30705482 30705504 23 - 2.240 1.989 -0.843
ENSG00000137337 E039 257.660829 0.0050032720 8.914147e-06 5.996798e-05 6 30705505 30705581 77 - 2.497 2.325 -0.573
ENSG00000137337 E040 173.546537 0.0010440744 7.767528e-16 2.976405e-14 6 30705582 30705627 46 - 2.362 2.120 -0.810
ENSG00000137337 E041 264.390016 0.0039214898 4.886485e-06 3.487460e-05 6 30705628 30705727 100 - 2.503 2.339 -0.545
ENSG00000137337 E042 132.178765 0.0007213110 1.163433e-18 6.372041e-17 6 30705728 30705750 23 - 2.266 1.981 -0.954
ENSG00000137337 E043 305.549957 0.0011280092 2.350129e-09 3.252904e-08 6 30705751 30705937 187 - 2.557 2.409 -0.494
ENSG00000137337 E044 218.849769 0.0022653166 1.078251e-02 3.064468e-02 6 30705938 30706098 161 - 2.371 2.294 -0.258
ENSG00000137337 E045 148.440764 0.0018471152 1.270935e-05 8.244304e-05 6 30707384 30707454 71 - 2.243 2.094 -0.498
ENSG00000137337 E046 14.850535 0.0013272469 1.731740e-05 1.089618e-04 6 30707455 30707565 111 - 1.382 1.015 -1.306
ENSG00000137337 E047 460.709290 0.0005667108 1.257870e-20 8.665441e-19 6 30707566 30708135 570 - 2.750 2.571 -0.596
ENSG00000137337 E048 312.929953 0.0025812307 2.984844e-11 5.751904e-10 6 30708136 30708357 222 - 2.595 2.393 -0.674
ENSG00000137337 E049 195.983980 0.0070869673 2.386560e-05 1.454532e-04 6 30711412 30711471 60 - 2.387 2.195 -0.639
ENSG00000137337 E050 152.690993 0.0034495496 4.175126e-07 3.751316e-06 6 30711472 30711501 30 - 2.282 2.085 -0.657
ENSG00000137337 E051 87.086004 0.0005584747 1.506569e-05 9.613495e-05 6 30711502 30711504 3 - 2.023 1.859 -0.551
ENSG00000137337 E052 172.933016 0.0035215763 2.702594e-08 3.070270e-07 6 30711667 30711726 60 - 2.345 2.134 -0.706
ENSG00000137337 E053 1301.236140 0.0089130588 1.247710e-09 1.814918e-08 6 30711874 30713354 1481 - 3.241 2.987 -0.846
ENSG00000137337 E054 158.327883 0.0204114516 3.250800e-06 2.413695e-05 6 30713648 30713717 70 - 2.363 2.031 -1.110
ENSG00000137337 E055 127.203449 0.0327596259 1.219486e-04 6.227336e-04 6 30713803 30713832 30 - 2.271 1.935 -1.128
ENSG00000137337 E056 213.034034 0.0094376572 2.224431e-11 4.378304e-10 6 30713833 30713939 107 - 2.498 2.153 -1.153
ENSG00000137337 E057 140.942723 0.0084756916 2.182307e-10 3.629140e-09 6 30713940 30713979 40 - 2.313 1.981 -1.113
ENSG00000137337 E058 276.489865 0.0084907955 6.235929e-13 1.582316e-11 6 30713980 30714183 204 - 2.611 2.265 -1.155
ENSG00000137337 E059 183.984873 0.0059110222 9.749037e-19 5.397211e-17 6 30715040 30715178 139 - 2.456 2.059 -1.327
ENSG00000137337 E060 10.352380 0.1254563729 1.303458e-02 3.599338e-02 6 30716882 30717083 202 - 1.265 0.818 -1.644
ENSG00000137337 E061 22.627974 0.0354487195 8.053490e-04 3.277783e-03 6 30717084 30717244 161 - 1.553 1.180 -1.297
ENSG00000137337 E062 58.050755 0.0104183698 2.814052e-10 4.600171e-09 6 30717245 30717248 4 - 1.974 1.546 -1.446
ENSG00000137337 E063 68.949808 0.0100468450 1.656664e-11 3.328914e-10 6 30717249 30717901 653 - 2.050 1.615 -1.466
ENSG00000137337 E064 3.478239 0.0049552069 3.429466e-03 1.152281e-02 6 30720101 30720563 463 - 0.855 0.423 -1.901