ENSG00000137310

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376255 ENSG00000137310 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF19 protein_coding protein_coding 30.0042 38.93415 24.64117 2.54631 0.6360585 -0.6597504 15.052769 18.133066 14.893631 1.5749766 0.44024408 -0.2837544 0.50923750 0.4648667 0.6043333 0.13946667 6.227088e-05 5.25208e-28 FALSE TRUE
ENST00000376257 ENSG00000137310 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF19 protein_coding protein_coding 30.0042 38.93415 24.64117 2.54631 0.6360585 -0.6597504 6.966493 6.229163 5.313981 0.9082125 0.21099471 -0.2288469 0.24142083 0.1595000 0.2155667 0.05606667 1.753679e-01 5.25208e-28 FALSE TRUE
ENST00000496421 ENSG00000137310 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF19 protein_coding processed_transcript 30.0042 38.93415 24.64117 2.54631 0.6360585 -0.6597504 2.871263 8.116933 0.000000 1.4964084 0.00000000 -9.6665673 0.07734583 0.2071000 0.0000000 -0.20710000 5.252080e-28 5.25208e-28 FALSE TRUE
MSTRG.28005.1 ENSG00000137310 HEK293_OSMI2_2hA HEK293_TMG_2hB TCF19 protein_coding   30.0042 38.93415 24.64117 2.54631 0.6360585 -0.6597504 3.494395 3.943971 2.850078 0.4510740 0.07841132 -0.4672477 0.12030417 0.1032000 0.1160000 0.01280000 8.028117e-01 5.25208e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137310 E001 1.319035 0.0098039668 9.711042e-01 9.859470e-01 6 31158515 31158533 19 + 0.343 0.365 0.132
ENSG00000137310 E002 3.666004 0.2239869738 7.087617e-01 8.063269e-01 6 31158534 31158546 13 + 0.698 0.609 -0.383
ENSG00000137310 E003 25.341870 0.0029796475 8.673261e-02 1.701766e-01 6 31158547 31158588 42 + 1.464 1.365 -0.341
ENSG00000137310 E004 121.719494 0.0026746614 1.301783e-05 8.417992e-05 6 31158589 31158722 134 + 2.160 2.010 -0.502
ENSG00000137310 E005 75.916955 0.0003523401 2.530915e-04 1.188170e-03 6 31158897 31159035 139 + 1.945 1.824 -0.407
ENSG00000137310 E006 40.483183 0.0029615215 1.723271e-02 4.546091e-02 6 31159036 31159142 107 + 1.673 1.557 -0.396
ENSG00000137310 E007 487.527532 0.0006938200 1.225189e-04 6.254268e-04 6 31159143 31159707 565 + 2.701 2.654 -0.156
ENSG00000137310 E008 100.858391 0.0003262324 9.499054e-04 3.787606e-03 6 31161447 31161448 2 + 2.048 1.959 -0.301
ENSG00000137310 E009 147.805768 0.0012109062 1.989794e-03 7.195137e-03 6 31161449 31161483 35 + 2.204 2.130 -0.246
ENSG00000137310 E010 212.517161 0.0002266474 6.784472e-02 1.397929e-01 6 31161484 31161577 94 + 2.326 2.310 -0.057
ENSG00000137310 E011 305.223030 0.0001572601 3.855560e-01 5.297460e-01 6 31161578 31161750 173 + 2.463 2.474 0.034
ENSG00000137310 E012 372.144987 0.0028309435 8.651001e-01 9.170861e-01 6 31161751 31162005 255 + 2.534 2.562 0.092
ENSG00000137310 E013 435.284186 0.0001533412 1.566565e-01 2.706474e-01 6 31162477 31162816 340 + 2.589 2.641 0.175
ENSG00000137310 E014 1343.375758 0.0021212196 1.004452e-06 8.328534e-06 6 31162817 31164215 1399 + 3.036 3.145 0.362
ENSG00000137310 E015 10.111840 0.0016568459 3.944045e-01 5.382476e-01 6 31166280 31166365 86 + 0.955 1.072 0.430
ENSG00000137310 E016 7.774610 0.0022457216 2.411539e-01 3.755395e-01 6 31166998 31167172 175 + 0.821 0.987 0.631