ENSG00000137275

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259808 ENSG00000137275 HEK293_OSMI2_2hA HEK293_TMG_2hB RIPK1 protein_coding protein_coding 11.32234 8.800621 16.73633 0.4142052 0.3594296 0.9265293 8.2659821 5.6572219 12.54020172 0.86765760 0.11835731 1.1469970 0.71175000 0.63623333 0.750133333 0.11390000 4.519290e-01 3.566988e-08 FALSE TRUE
ENST00000380409 ENSG00000137275 HEK293_OSMI2_2hA HEK293_TMG_2hB RIPK1 protein_coding protein_coding 11.32234 8.800621 16.73633 0.4142052 0.3594296 0.9265293 0.4283718 0.8676557 0.53944912 0.52599265 0.11889914 -0.6756692 0.03807083 0.10456667 0.032433333 -0.07213333 8.896711e-01 3.566988e-08 FALSE TRUE
ENST00000479389 ENSG00000137275 HEK293_OSMI2_2hA HEK293_TMG_2hB RIPK1 protein_coding processed_transcript 11.32234 8.800621 16.73633 0.4142052 0.3594296 0.9265293 0.1293796 0.0000000 0.93908909 0.00000000 0.17817094 6.5684716 0.00767500 0.00000000 0.055800000 0.05580000 3.566988e-08 3.566988e-08 FALSE TRUE
ENST00000678874 ENSG00000137275 HEK293_OSMI2_2hA HEK293_TMG_2hB RIPK1 protein_coding nonsense_mediated_decay 11.32234 8.800621 16.73633 0.4142052 0.3594296 0.9265293 0.6075065 0.2008584 0.86408787 0.03495154 0.11134270 2.0515036 0.05436250 0.02326667 0.051933333 0.02866667 7.207844e-02 3.566988e-08 FALSE TRUE
ENST00000679677 ENSG00000137275 HEK293_OSMI2_2hA HEK293_TMG_2hB RIPK1 protein_coding processed_transcript 11.32234 8.800621 16.73633 0.4142052 0.3594296 0.9265293 0.5730614 1.0417015 0.07233438 0.39586770 0.04303395 -3.6750864 0.06421667 0.11766667 0.004333333 -0.11333333 4.109148e-04 3.566988e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137275 E001 0.0000000       6 3063693 3063823 131 +      
ENSG00000137275 E002 0.0000000       6 3063824 3063833 10 +      
ENSG00000137275 E003 0.4482035 0.0333302566 2.288119e-01 3.610340e-01 6 3063834 3063861 28 + 0.218 0.000 -9.468
ENSG00000137275 E004 0.4482035 0.0333302566 2.288119e-01 3.610340e-01 6 3063862 3063862 1 + 0.218 0.000 -11.479
ENSG00000137275 E005 2.6700622 0.3452813368 4.905357e-01 6.278835e-01 6 3063863 3063905 43 + 0.558 0.491 -0.318
ENSG00000137275 E006 3.9569334 0.2975473272 5.083160e-01 6.437525e-01 6 3063906 3063966 61 + 0.691 0.618 -0.314
ENSG00000137275 E007 4.3850792 0.2370110938 1.701971e-01 2.884405e-01 6 3063967 3063978 12 + 0.792 0.482 -1.352
ENSG00000137275 E008 5.3878459 0.1364028116 4.252948e-01 5.682405e-01 6 3063979 3063990 12 + 0.822 0.697 -0.502
ENSG00000137275 E009 8.7374805 0.1417391895 7.020400e-01 8.009454e-01 6 3063991 3064059 69 + 0.911 1.046 0.501
ENSG00000137275 E010 1.5362266 0.0667607319 8.010193e-02 1.597124e-01 6 3064270 3064487 218 + 0.218 0.595 2.175
ENSG00000137275 E011 1.1351534 0.4102400947 3.813065e-01 5.256035e-01 6 3064488 3064721 234 + 0.218 0.468 1.575
ENSG00000137275 E012 1.6608786 0.0291286696 5.228238e-02 1.132242e-01 6 3068494 3068508 15 + 0.501 0.173 -2.153
ENSG00000137275 E013 4.1687196 0.0038489491 4.624892e-05 2.627832e-04 6 3068509 3068521 13 + 0.836 0.173 -3.586
ENSG00000137275 E014 20.0637381 0.0009213375 1.943899e-08 2.272966e-07 6 3068522 3068661 140 + 1.414 0.990 -1.508
ENSG00000137275 E015 0.8868421 0.0451713782 3.283021e-01 4.717858e-01 6 3068695 3068716 22 + 0.319 0.172 -1.157
ENSG00000137275 E016 1.9314286 0.0079980363 1.114489e-01 2.076707e-01 6 3068717 3068856 140 + 0.530 0.296 -1.293
ENSG00000137275 E017 0.7406253 0.0155721458 7.496916e-02 1.514848e-01 6 3073581 3073638 58 + 0.319 0.000 -12.351
ENSG00000137275 E018 0.7718584 0.0155931000 8.310880e-01 8.941063e-01 6 3073639 3073802 164 + 0.218 0.296 0.582
ENSG00000137275 E019 101.2706050 0.0003462369 1.169419e-08 1.424394e-07 6 3076764 3076987 224 + 2.030 1.903 -0.425
ENSG00000137275 E020 104.8222422 0.0003585534 2.829155e-06 2.129821e-05 6 3077779 3077935 157 + 2.032 1.948 -0.279
ENSG00000137275 E021 81.6255141 0.0009998958 7.677610e-04 3.142351e-03 6 3080979 3081116 138 + 1.917 1.861 -0.188
ENSG00000137275 E022 0.3268771 0.0294414887 6.567708e-01   6 3082547 3082660 114 + 0.085 0.173 1.169
ENSG00000137275 E023 1.6930301 0.0318142987 2.332150e-01 3.662443e-01 6 3082661 3083084 424 + 0.470 0.296 -1.000
ENSG00000137275 E024 109.0449974 0.0042056386 5.818775e-02 1.235222e-01 6 3083085 3083313 229 + 2.021 2.022 0.004
ENSG00000137275 E025 22.5108784 0.0017108839 3.861937e-05 2.234129e-04 6 3083314 3084783 1470 + 1.422 1.166 -0.894
ENSG00000137275 E026 10.3924894 0.0529583044 3.131156e-01 4.556467e-01 6 3084784 3085258 475 + 1.067 0.987 -0.295
ENSG00000137275 E027 79.7176115 0.0020556703 6.459057e-02 1.343606e-01 6 3085259 3085369 111 + 1.885 1.887 0.008
ENSG00000137275 E028 60.7151238 0.0161709159 2.027770e-01 3.296986e-01 6 3085370 3085408 39 + 1.774 1.759 -0.052
ENSG00000137275 E029 4.7374834 0.0039890533 7.579900e-02 1.527778e-01 6 3087604 3089580 1977 + 0.606 0.920 1.268
ENSG00000137275 E030 75.2197981 0.0097183756 3.812125e-02 8.758134e-02 6 3089581 3089657 77 + 1.877 1.828 -0.166
ENSG00000137275 E031 1.1750211 0.5131239063 6.314855e-01 7.464841e-01 6 3089658 3090136 479 + 0.218 0.474 1.597
ENSG00000137275 E032 0.7394793 0.0153787590 4.601455e-01 6.001968e-01 6 3090658 3090960 303 + 0.271 0.172 -0.833
ENSG00000137275 E033 1.1448044 0.1700702118 1.760081e-01 2.960062e-01 6 3094047 3094388 342 + 0.157 0.479 2.214
ENSG00000137275 E034 75.4661981 0.0077714409 5.824079e-02 1.236140e-01 6 3104225 3104315 91 + 1.872 1.843 -0.099
ENSG00000137275 E035 223.5622719 0.0007489200 1.882723e-04 9.135940e-04 6 3105482 3106051 570 + 2.336 2.326 -0.030
ENSG00000137275 E036 3.9095240 0.0091526437 1.572698e-02 4.212042e-02 6 3106052 3107237 1186 + 0.470 0.894 1.807
ENSG00000137275 E037 113.9761816 0.0054719762 5.967551e-01 7.186449e-01 6 3110803 3110955 153 + 1.996 2.107 0.372
ENSG00000137275 E038 1.1145163 0.0322884286 7.144548e-01 8.106587e-01 6 3110956 3111194 239 + 0.319 0.296 -0.154
ENSG00000137275 E039 712.5983763 0.0068186405 1.449366e-10 2.490051e-09 6 3113053 3115187 2135 + 2.724 2.985 0.869