ENSG00000137266

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000406686 ENSG00000137266 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC22A23 protein_coding protein_coding 6.797834 8.184032 5.111537 0.3782719 0.1715131 -0.6779967 5.9297439 7.0100823 4.727721 0.3377212 0.07350837 -0.5672947 0.87740000 0.85650000 0.9260333 0.06953333 7.752114e-02 5.703018e-06 FALSE  
ENST00000433689 ENSG00000137266 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC22A23 protein_coding processed_transcript 6.797834 8.184032 5.111537 0.3782719 0.1715131 -0.6779967 0.2917025 0.6616073 0.000000 0.1684810 0.00000000 -6.0695459 0.03682917 0.08126667 0.0000000 -0.08126667 5.703018e-06 5.703018e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137266 E001 0.1817044 0.0396879696 7.536286e-01   6 3268584 3268961 378 - 0.000 0.100 8.966
ENSG00000137266 E002 0.4815130 0.0204653399 8.792028e-01 9.264065e-01 6 3268962 3268972 11 - 0.148 0.182 0.352
ENSG00000137266 E003 24.2475478 0.0027391520 4.526236e-05 2.577575e-04 6 3268973 3269107 135 - 1.121 1.475 1.240
ENSG00000137266 E004 94.0162968 0.0020468396 1.093975e-11 2.264289e-10 6 3269108 3269388 281 - 1.715 2.044 1.108
ENSG00000137266 E005 499.0018749 0.0019290376 1.454585e-09 2.090953e-08 6 3269389 3271235 1847 - 2.574 2.722 0.495
ENSG00000137266 E006 136.1881643 0.0002546736 3.869398e-01 5.311119e-01 6 3271236 3271773 538 - 2.085 2.129 0.148
ENSG00000137266 E007 144.2512292 0.0053181352 1.481115e-01 2.591163e-01 6 3271774 3272491 718 - 2.165 2.123 -0.143
ENSG00000137266 E008 72.4004420 0.0004137789 5.681466e-04 2.414502e-03 6 3272492 3272828 337 - 1.918 1.792 -0.426
ENSG00000137266 E009 21.7714528 0.0008376041 3.604016e-01 5.047171e-01 6 3272829 3272829 1 - 1.369 1.317 -0.180
ENSG00000137266 E010 100.1250822 0.0003436347 8.256557e-02 1.635607e-01 6 3272830 3273355 526 - 2.010 1.965 -0.150
ENSG00000137266 E011 31.9054719 0.0019490932 6.861283e-02 1.410672e-01 6 3273356 3273412 57 - 1.556 1.456 -0.343
ENSG00000137266 E012 0.8010032 0.1115971741 3.613296e-01 5.057280e-01 6 3276681 3276976 296 - 0.346 0.182 -1.225
ENSG00000137266 E013 10.0357368 0.0018488555 1.504197e-02 4.058415e-02 6 3283465 3283851 387 - 0.799 1.095 1.114
ENSG00000137266 E014 23.5639035 0.0014748565 6.026155e-03 1.868014e-02 6 3283852 3283873 22 - 1.476 1.295 -0.625
ENSG00000137266 E015 48.4582307 0.0051747758 7.107844e-02 1.451316e-01 6 3283874 3283975 102 - 1.725 1.635 -0.307
ENSG00000137266 E016 0.1482932 0.0417854855 7.545031e-01   6 3283976 3284120 145 - 0.000 0.100 10.957
ENSG00000137266 E017 0.5149242 0.2286254657 9.212365e-01 9.543047e-01 6 3284936 3284959 24 - 0.149 0.183 0.359
ENSG00000137266 E018 29.7364532 0.0007056053 1.595263e-01 2.744889e-01 6 3285079 3285111 33 - 1.510 1.436 -0.254
ENSG00000137266 E019 47.1877843 0.0005032871 1.761588e-02 4.630475e-02 6 3286859 3286983 125 - 1.722 1.616 -0.358
ENSG00000137266 E020 51.5577406 0.0012216809 3.076943e-01 4.499244e-01 6 3286984 3287091 108 - 1.722 1.687 -0.120
ENSG00000137266 E021 27.3376483 0.0017024566 6.122732e-01 7.312377e-01 6 3289764 3289765 2 - 1.445 1.427 -0.062
ENSG00000137266 E022 52.1464132 0.0004471420 8.141181e-03 2.414197e-02 6 3289766 3289866 101 - 1.772 1.660 -0.380
ENSG00000137266 E023 55.8706064 0.0004641264 5.467839e-03 1.720193e-02 6 3298091 3298218 128 - 1.801 1.687 -0.387
ENSG00000137266 E024 0.0000000       6 3323266 3323318 53 -      
ENSG00000137266 E025 7.0373779 0.0174873255 2.728577e-04 1.269265e-03 6 3323342 3323833 492 - 0.420 1.006 2.489
ENSG00000137266 E026 34.8190440 0.0014244682 1.463702e-01 2.567417e-01 6 3323834 3323886 53 - 1.571 1.498 -0.249
ENSG00000137266 E027 51.8383114 0.0004903603 5.191183e-02 1.125684e-01 6 3323887 3324002 116 - 1.751 1.672 -0.266
ENSG00000137266 E028 0.1472490 0.0431059095 3.065274e-01   6 3324097 3324183 87 - 0.148 0.000 -12.474
ENSG00000137266 E029 0.0000000       6 3377824 3377986 163 -      
ENSG00000137266 E030 44.5703526 0.0100569884 3.155400e-02 7.498697e-02 6 3410188 3410342 155 - 1.722 1.591 -0.446
ENSG00000137266 E031 28.8078390 0.0007243345 4.700181e-02 1.038316e-01 6 3415752 3415855 104 - 1.526 1.414 -0.384
ENSG00000137266 E032 0.0000000       6 3432094 3432338 245 -      
ENSG00000137266 E033 0.0000000       6 3438484 3438555 72 -      
ENSG00000137266 E034 0.1817044 0.0396879696 7.536286e-01   6 3439297 3439418 122 - 0.000 0.100 10.978
ENSG00000137266 E035 0.1482932 0.0417854855 7.545031e-01   6 3444819 3445013 195 - 0.000 0.100 10.957
ENSG00000137266 E036 58.4817878 0.0005477947 2.013601e-06 1.565522e-05 6 3455906 3457050 1145 - 1.873 1.673 -0.678