ENSG00000137216

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259746 ENSG00000137216 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM63B protein_coding protein_coding 15.45335 18.00648 10.4733 0.8673957 0.1025329 -0.7812237 1.967767 1.8948975 1.8362821 0.79197994 0.28650065 -0.04509035 0.13675833 0.10240000 0.17580000 0.073400000 0.436155233 0.005546491 FALSE TRUE
ENST00000323267 ENSG00000137216 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM63B protein_coding protein_coding 15.45335 18.00648 10.4733 0.8673957 0.1025329 -0.7812237 7.981675 7.6165390 6.4029777 0.77550181 0.42546633 -0.25003411 0.51940833 0.42116667 0.61080000 0.189633333 0.010858999 0.005546491 FALSE TRUE
ENST00000371893 ENSG00000137216 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM63B protein_coding protein_coding 15.45335 18.00648 10.4733 0.8673957 0.1025329 -0.7812237 3.123417 6.1368962 0.2857874 0.57395356 0.17659569 -4.37722538 0.18543333 0.34523333 0.02760000 -0.317633333 0.005546491 0.005546491 FALSE TRUE
ENST00000534326 ENSG00000137216 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM63B protein_coding retained_intron 15.45335 18.00648 10.4733 0.8673957 0.1025329 -0.7812237 0.760250 0.4498027 0.5414129 0.07403533 0.09458624 0.26211816 0.05007083 0.02473333 0.05163333 0.026900000 0.076784344 0.005546491 FALSE TRUE
MSTRG.28354.5 ENSG00000137216 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM63B protein_coding   15.45335 18.00648 10.4733 0.8673957 0.1025329 -0.7812237 1.171829 1.7199803 1.0191639 0.09302394 0.07276167 -0.74928295 0.07663750 0.09630000 0.09743333 0.001133333 1.000000000 0.005546491 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137216 E001 0.4031496 0.0245703265 4.092174e-01 5.528222e-01 6 44125681 44126913 1233 + 0.000 0.175 11.030
ENSG00000137216 E002 8.6962126 0.0096862230 1.506454e-01 2.625537e-01 6 44126914 44127072 159 + 1.051 0.901 -0.557
ENSG00000137216 E003 3.8633162 0.0041043285 6.974741e-02 1.429523e-01 6 44127073 44127141 69 + 0.816 0.572 -1.024
ENSG00000137216 E004 0.1472490 0.0428556742 2.762940e-01   6 44127554 44127568 15 + 0.154 0.000 -11.868
ENSG00000137216 E005 1.9907598 0.0071379296 3.184974e-01 4.614684e-01 6 44127569 44127626 58 + 0.552 0.396 -0.782
ENSG00000137216 E006 4.7542953 0.0035085057 1.725471e-01 2.915125e-01 6 44127627 44127638 12 + 0.844 0.674 -0.683
ENSG00000137216 E007 16.9652491 0.0010594092 3.413683e-02 8.002871e-02 6 44127639 44127678 40 + 1.324 1.166 -0.556
ENSG00000137216 E008 5.5585051 0.0259767373 4.837129e-01 6.217445e-01 6 44127679 44127719 41 + 0.843 0.758 -0.336
ENSG00000137216 E009 10.2416993 0.0018733536 9.739422e-01 9.877432e-01 6 44127720 44127866 147 + 1.017 1.038 0.079
ENSG00000137216 E010 3.2474275 0.0112187625 5.805459e-02 1.233031e-01 6 44134420 44134560 141 + 0.756 0.476 -1.237
ENSG00000137216 E011 74.7646418 0.0003711496 1.292812e-02 3.574317e-02 6 44134561 44134743 183 + 1.903 1.818 -0.286
ENSG00000137216 E012 37.5789587 0.0006911737 7.241086e-02 1.473535e-01 6 44135017 44135032 16 + 1.614 1.528 -0.293
ENSG00000137216 E013 71.3969535 0.0004117960 2.356959e-04 1.115468e-03 6 44135033 44135096 64 + 1.914 1.777 -0.463
ENSG00000137216 E014 71.9929155 0.0009917990 7.459831e-04 3.064273e-03 6 44135328 44135366 39 + 1.912 1.783 -0.436
ENSG00000137216 E015 81.1362391 0.0024723826 1.095460e-04 5.659591e-04 6 44136349 44136398 50 + 1.979 1.823 -0.524
ENSG00000137216 E016 75.2115309 0.0014950810 4.021712e-04 1.782811e-03 6 44136399 44136439 41 + 1.936 1.799 -0.463
ENSG00000137216 E017 0.4375944 0.0274118517 2.628943e-02 6.452953e-02 6 44138374 44138479 106 + 0.358 0.000 -13.453
ENSG00000137216 E018 66.9620661 0.0005142969 4.254849e-03 1.385497e-02 6 44138480 44138517 38 + 1.867 1.759 -0.364
ENSG00000137216 E019 0.1472490 0.0428556742 2.762940e-01   6 44138813 44138931 119 + 0.154 0.000 -11.868
ENSG00000137216 E020 119.1771286 0.0046199533 1.563032e-03 5.839315e-03 6 44139467 44139609 143 + 2.128 2.006 -0.407
ENSG00000137216 E021 52.9962028 0.0076037907 5.929172e-02 1.254222e-01 6 44139708 44139711 4 + 1.771 1.672 -0.335
ENSG00000137216 E022 79.6867747 0.0056493971 1.194211e-01 2.191163e-01 6 44139712 44139759 48 + 1.921 1.859 -0.208
ENSG00000137216 E023 99.1109658 0.0003723775 2.368510e-01 3.705323e-01 6 44140252 44140360 109 + 1.985 1.961 -0.082
ENSG00000137216 E024 1.5781470 0.0093072680 3.004114e-02 7.203692e-02 6 44140361 44140513 153 + 0.601 0.242 -2.005
ENSG00000137216 E025 87.8540474 0.0003022493 4.250153e-02 9.563261e-02 6 44141028 44141098 71 + 1.955 1.896 -0.200
ENSG00000137216 E026 87.4099284 0.0003360908 1.562217e-01 2.700854e-01 6 44146847 44146927 81 + 1.936 1.900 -0.122
ENSG00000137216 E027 131.4347219 0.0003562885 1.471430e-02 3.984647e-02 6 44147377 44147500 124 + 2.126 2.067 -0.198
ENSG00000137216 E028 145.1075455 0.0019048725 1.964787e-01 3.218224e-01 6 44148252 44148385 134 + 2.148 2.122 -0.086
ENSG00000137216 E029 142.0009774 0.0003024032 7.308432e-02 1.484656e-01 6 44148513 44148650 138 + 2.145 2.109 -0.120
ENSG00000137216 E030 170.5210664 0.0002304618 2.160860e-01 3.456950e-01 6 44148792 44148945 154 + 2.213 2.198 -0.051
ENSG00000137216 E031 5.2776480 0.0032394174 4.374903e-01 5.794512e-01 6 44148946 44149261 316 + 0.685 0.810 0.506
ENSG00000137216 E032 139.9599402 0.0009568602 9.048819e-01 9.434471e-01 6 44149859 44149965 107 + 2.104 2.128 0.082
ENSG00000137216 E033 116.9630656 0.0013616852 3.588315e-01 5.032167e-01 6 44150224 44150310 87 + 2.006 2.061 0.185
ENSG00000137216 E034 98.0817954 0.0027796527 2.797799e-01 4.195536e-01 6 44150564 44150629 66 + 1.919 1.988 0.234
ENSG00000137216 E035 140.2356955 0.0003766132 2.821296e-03 9.737759e-03 6 44151846 44152008 163 + 2.032 2.150 0.395
ENSG00000137216 E036 115.1071287 0.0017553521 1.786384e-02 4.684343e-02 6 44152593 44152698 106 + 1.949 2.065 0.389
ENSG00000137216 E037 157.6351907 0.0003586151 3.914766e-02 8.945670e-02 6 44153676 44153843 168 + 2.108 2.191 0.278
ENSG00000137216 E038 160.7242159 0.0002773971 2.752729e-06 2.078088e-05 6 44154073 44154188 116 + 2.061 2.225 0.549
ENSG00000137216 E039 135.5853897 0.0038335460 2.016860e-05 1.249715e-04 6 44154365 44154445 81 + 1.953 2.165 0.710
ENSG00000137216 E040 311.2032256 0.0127338539 1.523387e-06 1.216341e-05 6 44154692 44155519 828 + 2.246 2.542 0.986