ENSG00000137203

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379608 ENSG00000137203 HEK293_OSMI2_2hA HEK293_TMG_2hB TFAP2A protein_coding protein_coding 22.35506 24.90341 18.88116 1.798896 0.1773736 -0.3992111 3.8200259 4.9243142 3.210435 0.4043597 0.2948938 -0.6155942 0.16950833 0.2003667 0.16976667 -0.03060000 0.698033424 0.001133743 FALSE TRUE
ENST00000379613 ENSG00000137203 HEK293_OSMI2_2hA HEK293_TMG_2hB TFAP2A protein_coding protein_coding 22.35506 24.90341 18.88116 1.798896 0.1773736 -0.3992111 6.4847669 9.7467740 3.747211 0.9114138 0.3733575 -1.3767421 0.28303750 0.3939000 0.19820000 -0.19570000 0.001341199 0.001133743 FALSE TRUE
ENST00000461628 ENSG00000137203 HEK293_OSMI2_2hA HEK293_TMG_2hB TFAP2A protein_coding protein_coding 22.35506 24.90341 18.88116 1.798896 0.1773736 -0.3992111 2.3477953 4.0006130 1.219529 0.2754492 0.3992096 -1.7057167 0.10169583 0.1619667 0.06420000 -0.09776667 0.092102647 0.001133743   FALSE
ENST00000475264 ENSG00000137203 HEK293_OSMI2_2hA HEK293_TMG_2hB TFAP2A protein_coding protein_coding 22.35506 24.90341 18.88116 1.798896 0.1773736 -0.3992111 1.5919423 0.8492385 1.790496 0.4568833 0.4397214 1.0672641 0.07264583 0.0331000 0.09513333 0.06203333 0.201939448 0.001133743 FALSE FALSE
ENST00000478375 ENSG00000137203 HEK293_OSMI2_2hA HEK293_TMG_2hB TFAP2A protein_coding retained_intron 22.35506 24.90341 18.88116 1.798896 0.1773736 -0.3992111 1.8264717 0.9040639 1.768894 0.1460566 0.2320091 0.9606134 0.08548333 0.0360000 0.09346667 0.05746667 0.001133743 0.001133743 FALSE TRUE
ENST00000488193 ENSG00000137203 HEK293_OSMI2_2hA HEK293_TMG_2hB TFAP2A protein_coding nonsense_mediated_decay 22.35506 24.90341 18.88116 1.798896 0.1773736 -0.3992111 0.5299617 0.0000000 1.277086 0.0000000 0.6431322 7.0079641 0.02552500 0.0000000 0.06766667 0.06766667 0.160282118 0.001133743 FALSE TRUE
ENST00000489805 ENSG00000137203 HEK293_OSMI2_2hA HEK293_TMG_2hB TFAP2A protein_coding nonsense_mediated_decay 22.35506 24.90341 18.88116 1.798896 0.1773736 -0.3992111 2.9473080 1.8692972 2.610245 1.0873255 0.7598886 0.4795085 0.13290417 0.0694000 0.13860000 0.06920000 0.682830064 0.001133743 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137203 E001 2.7344910 0.0069577908 3.515597e-01 4.958062e-01 6 10385887 10385913 27 - 0.624 0.494 -0.596
ENSG00000137203 E002 2.8753206 0.0054545419 4.483840e-01 5.896747e-01 6 10385914 10385975 62 - 0.477 0.621 0.665
ENSG00000137203 E003 2.9796952 0.0050213901 9.605331e-01 9.791552e-01 6 10385976 10386031 56 - 0.580 0.592 0.055
ENSG00000137203 E004 15.2885501 0.0310641705 2.590696e-01 3.964327e-01 6 10393186 10393309 124 - 1.087 1.245 0.566
ENSG00000137203 E005 48.8909517 0.0058454498 7.866518e-04 3.211482e-03 6 10393310 10393561 252 - 1.503 1.752 0.849
ENSG00000137203 E006 2.8807991 0.0053615051 7.690250e-04 3.146641e-03 6 10395656 10395804 149 - 0.820 0.314 -2.403
ENSG00000137203 E007 211.6556444 0.0139398024 2.099961e-05 1.296206e-04 6 10396677 10397409 733 - 2.095 2.392 0.994
ENSG00000137203 E008 309.8491010 0.0082682211 1.715420e-05 1.080210e-04 6 10397410 10397871 462 - 2.308 2.541 0.778
ENSG00000137203 E009 73.5081736 0.0069722625 7.045318e-02 1.440909e-01 6 10397872 10397914 43 - 1.756 1.895 0.468
ENSG00000137203 E010 93.4774447 0.0040713810 7.900525e-08 8.185566e-07 6 10397915 10398012 98 - 1.734 2.039 1.025
ENSG00000137203 E011 283.1129119 0.0003115117 1.114141e-01 2.076262e-01 6 10398013 10398601 589 - 2.385 2.449 0.212
ENSG00000137203 E012 158.6037338 0.0002708430 1.173322e-02 3.289710e-02 6 10398602 10398687 86 - 2.205 2.159 -0.153
ENSG00000137203 E013 107.6224581 0.0003823291 3.001071e-02 7.198216e-02 6 10398688 10398705 18 - 2.039 1.990 -0.166
ENSG00000137203 E014 192.7882597 0.0002234007 2.076945e-03 7.462560e-03 6 10400448 10400589 142 - 2.295 2.242 -0.177
ENSG00000137203 E015 11.8785409 0.0044179841 2.291854e-07 2.172554e-06 6 10400714 10400791 78 - 1.339 0.850 -1.774
ENSG00000137203 E016 22.0522616 0.0008595076 1.388143e-07 1.372688e-06 6 10402026 10402491 466 - 1.534 1.177 -1.244
ENSG00000137203 E017 114.0123107 0.0024483742 4.424340e-01 5.840513e-01 6 10402492 10402537 46 - 2.041 2.038 -0.011
ENSG00000137203 E018 141.4049797 0.0021007119 6.972033e-01 7.973791e-01 6 10402538 10402610 73 - 2.118 2.133 0.051
ENSG00000137203 E019 166.5024322 0.0080062338 4.701036e-01 6.093141e-01 6 10404508 10404620 113 - 2.204 2.200 -0.015
ENSG00000137203 E020 126.9596480 0.0047749482 1.123812e-01 2.090131e-01 6 10404621 10404667 47 - 2.113 2.070 -0.145
ENSG00000137203 E021 134.6495861 0.0035321819 9.411498e-02 1.815680e-01 6 10404668 10404739 72 - 2.134 2.094 -0.133
ENSG00000137203 E022 5.9107451 0.0028704599 3.936032e-03 1.296163e-02 6 10406136 10406792 657 - 1.009 0.672 -1.314
ENSG00000137203 E023 73.5416944 0.0007117962 7.396691e-02 1.498613e-01 6 10406793 10406793 1 - 1.878 1.828 -0.168
ENSG00000137203 E024 115.2386483 0.0003147725 2.118326e-02 5.398383e-02 6 10406794 10406844 51 - 2.071 2.020 -0.171
ENSG00000137203 E025 2.2102450 0.1117197550 5.199716e-02 1.127193e-01 6 10409086 10409900 815 - 0.699 0.314 -1.913
ENSG00000137203 E026 138.1339613 0.0018224066 2.788239e-03 9.639115e-03 6 10409901 10409996 96 - 2.166 2.088 -0.262
ENSG00000137203 E027 111.1554059 0.0003507087 1.779835e-02 4.670403e-02 6 10409997 10410138 142 - 2.059 2.005 -0.184
ENSG00000137203 E028 78.5430303 0.0022907877 1.040418e-01 1.966636e-01 6 10410139 10410277 139 - 1.907 1.860 -0.158
ENSG00000137203 E029 41.8240284 0.0051960463 4.791028e-01 6.175087e-01 6 10410278 10410281 4 - 1.621 1.602 -0.065
ENSG00000137203 E030 64.8204470 0.0013986465 3.964866e-03 1.304547e-02 6 10410282 10410335 54 - 1.861 1.753 -0.364
ENSG00000137203 E031 1.8454854 0.0079876006 4.471474e-01 5.885755e-01 6 10410860 10411018 159 - 0.343 0.494 0.817
ENSG00000137203 E032 123.9543028 0.0035489644 7.724189e-02 1.550674e-01 6 10411570 10412391 822 - 2.101 2.056 -0.152
ENSG00000137203 E033 0.8502072 0.0142842540 9.389553e-01 9.656704e-01 6 10412602 10412879 278 - 0.255 0.254 -0.012
ENSG00000137203 E034 48.1152329 0.0050453246 1.791590e-01 3.000958e-01 6 10414941 10415069 129 - 1.701 1.647 -0.183
ENSG00000137203 E035 30.7616559 0.0112413688 5.911606e-01 7.139627e-01 6 10415070 10415206 137 - 1.486 1.471 -0.052
ENSG00000137203 E036 1.0653097 0.0124232078 8.014989e-01 8.735262e-01 6 10415922 10416190 269 - 0.255 0.314 0.405
ENSG00000137203 E037 0.0000000       6 10416921 10417207 287 -      
ENSG00000137203 E038 0.3268771 0.0286819747 7.300369e-01   6 10418189 10418684 496 - 0.146 0.102 -0.597
ENSG00000137203 E039 1.3201807 0.0134996430 5.118901e-01 6.468131e-01 6 10419418 10419571 154 - 0.415 0.314 -0.596
ENSG00000137203 E040 0.8719902 0.6848937985 7.666028e-01 8.490587e-01 6 10419572 10419659 88 - 0.146 0.317 1.428