ENSG00000137177

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-7 / 7
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000378814	ENSG00000137177	HEK293_OSMI2_2hA	HEK293_TMG_2hB	KIF13A	protein_coding	protein_coding	6.327461	5.479567	7.845583	0.4838179	0.3134418	0.5170261	2.6187170	1.7661702	3.3767426	0.31638813	0.29530956	0.93112850	0.40759167	0.31660000	0.42926667	0.11266667	1.733541e-01	1.458963e-18	FALSE	TRUE
ENST00000378826	ENSG00000137177	HEK293_OSMI2_2hA	HEK293_TMG_2hB	KIF13A	protein_coding	protein_coding	6.327461	5.479567	7.845583	0.4838179	0.3134418	0.5170261	0.3853339	0.3771147	0.3300876	0.08752164	0.17518715	-0.18685456	0.06230000	0.07316667	0.04246667	-0.03070000	6.801967e-01	1.458963e-18	FALSE	TRUE
ENST00000502297	ENSG00000137177	HEK293_OSMI2_2hA	HEK293_TMG_2hB	KIF13A	protein_coding	protein_coding	6.327461	5.479567	7.845583	0.4838179	0.3134418	0.5170261	1.1107701	1.8559719	0.6633373	0.15295806	0.05686092	-1.47052603	0.19699167	0.34510000	0.08533333	-0.25976667	8.400307e-07	1.458963e-18	FALSE	TRUE
ENST00000502704	ENSG00000137177	HEK293_OSMI2_2hA	HEK293_TMG_2hB	KIF13A	protein_coding	protein_coding	6.327461	5.479567	7.845583	0.4838179	0.3134418	0.5170261	0.6526063	0.9053330	0.9542370	0.10603033	0.14223977	0.07509117	0.10300000	0.16513333	0.12123333	-0.04390000	4.409136e-01	1.458963e-18		FALSE
ENST00000506044	ENSG00000137177	HEK293_OSMI2_2hA	HEK293_TMG_2hB	KIF13A	protein_coding	protein_coding	6.327461	5.479567	7.845583	0.4838179	0.3134418	0.5170261	0.4003634	0.1417426	0.6257665	0.02333196	0.16025694	2.06687047	0.05859167	0.02590000	0.07893333	0.05303333	6.914851e-02	1.458963e-18	FALSE	FALSE
MSTRG.27696.2	ENSG00000137177	HEK293_OSMI2_2hA	HEK293_TMG_2hB	KIF13A	protein_coding		6.327461	5.479567	7.845583	0.4838179	0.3134418	0.5170261	0.3705948	0.2519535	0.0000000	0.25195353	0.00000000	-4.71123900	0.05834167	0.04253333	0.00000000	-0.04253333	7.238142e-01	1.458963e-18	FALSE	TRUE
MSTRG.27696.4	ENSG00000137177	HEK293_OSMI2_2hA	HEK293_TMG_2hB	KIF13A	protein_coding		6.327461	5.479567	7.845583	0.4838179	0.3134418	0.5170261	0.5042368	0.0000000	1.4400036	0.00000000	0.02389674	7.17991267	0.06953750	0.00000000	0.18433333	0.18433333	1.458963e-18	1.458963e-18	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 55
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000137177	E001	0.7352249	0.4710244632	6.046590e-01	7.251029e-01	6	17759183	17759253	71	-	0.180	0.335	1.173
ENSG00000137177	E002	170.8432994	0.0071822343	1.448901e-15	5.362243e-14	6	17759254	17760502	1249	-	2.023	2.412	1.299
ENSG00000137177	E003	61.7178542	0.0056361334	2.707826e-04	1.260850e-03	6	17760503	17760877	375	-	1.686	1.916	0.776
ENSG00000137177	E004	0.0000000				6	17763693	17763694	2	-
ENSG00000137177	E005	6.9622459	0.0126635502	3.681289e-02	8.511010e-02	6	17763695	17764109	415	-	0.752	1.035	1.078
ENSG00000137177	E006	2.4367576	0.1849247145	1.900497e-01	3.138400e-01	6	17764110	17764154	45	-	0.360	0.676	1.536
ENSG00000137177	E007	134.3318865	0.0004446219	1.355223e-01	2.418487e-01	6	17764155	17764946	792	-	2.099	2.168	0.229
ENSG00000137177	E008	0.3289534	0.0292153524	7.680777e-01		6	17770365	17771113	749	-	0.100	0.149	0.664
ENSG00000137177	E009	12.5512911	0.0016987915	9.664172e-01	9.829214e-01	6	17771114	17771218	105	-	1.119	1.137	0.063
ENSG00000137177	E010	0.5943067	0.0247022944	5.387512e-01	6.701392e-01	6	17771219	17771907	689	-	0.249	0.149	-0.924
ENSG00000137177	E011	52.9567672	0.0010510245	9.000079e-01	9.402023e-01	6	17771908	17772059	152	-	1.724	1.740	0.055
ENSG00000137177	E012	47.0818244	0.0005027809	5.686548e-01	6.952742e-01	6	17773478	17773583	106	-	1.684	1.678	-0.020
ENSG00000137177	E013	30.5706903	0.0006918539	5.796530e-01	7.045005e-01	6	17775015	17775062	48	-	1.502	1.490	-0.042
ENSG00000137177	E014	30.0426373	0.0007843758	9.217956e-01	9.546456e-01	6	17777277	17777354	78	-	1.473	1.501	0.098
ENSG00000137177	E015	39.1351479	0.0139217842	9.932953e-01	9.999619e-01	6	17778947	17779099	153	-	1.589	1.605	0.056
ENSG00000137177	E016	32.4456148	0.0138186296	5.954357e-01	7.175367e-01	6	17779592	17779684	93	-	1.530	1.499	-0.106
ENSG00000137177	E017	25.5121317	0.0039676992	6.129177e-01	7.317492e-01	6	17780730	17780759	30	-	1.425	1.408	-0.059
ENSG00000137177	E018	35.3939379	0.0010151067	4.168716e-01	5.602539e-01	6	17780760	17780906	147	-	1.530	1.601	0.243
ENSG00000137177	E019	28.5014516	0.0007175088	4.725685e-01	6.116300e-01	6	17781177	17781301	125	-	1.437	1.507	0.238
ENSG00000137177	E020	16.8667155	0.0069780427	7.789616e-01	8.578068e-01	6	17783646	17783701	56	-	1.232	1.278	0.164
ENSG00000137177	E021	23.2876153	0.0008389485	7.607848e-01	8.447779e-01	6	17785515	17785592	78	-	1.385	1.386	0.004
ENSG00000137177	E022	22.8115106	0.0008669119	8.380534e-01	8.987541e-01	6	17785593	17785641	49	-	1.356	1.394	0.129
ENSG00000137177	E023	34.3726533	0.0014082445	2.605618e-01	3.981052e-01	6	17787776	17787875	100	-	1.565	1.518	-0.161
ENSG00000137177	E024	6.8856028	0.0080148741	2.136370e-01	3.428201e-01	6	17789872	17789910	39	-	0.943	0.801	-0.542
ENSG00000137177	E025	30.6065209	0.0054413591	2.868551e-01	4.272985e-01	6	17794249	17794395	147	-	1.516	1.461	-0.189
ENSG00000137177	E026	34.0182118	0.0135138972	3.412889e-01	4.852026e-01	6	17794572	17794704	133	-	1.562	1.500	-0.212
ENSG00000137177	E027	0.0000000				6	17794860	17795032	173	-
ENSG00000137177	E028	35.0516727	0.0008851507	3.044475e-01	4.464520e-01	6	17796669	17796820	152	-	1.568	1.529	-0.133
ENSG00000137177	E029	39.1760046	0.0005658499	2.327524e-01	3.657089e-01	6	17799266	17799439	174	-	1.622	1.578	-0.149
ENSG00000137177	E030	39.6174443	0.0006765619	3.057648e-02	7.310033e-02	6	17799952	17800113	162	-	1.648	1.549	-0.337
ENSG00000137177	E031	38.2363966	0.0005823902	2.924851e-03	1.004412e-02	6	17804361	17804510	150	-	1.650	1.501	-0.509
ENSG00000137177	E032	34.4949840	0.0086431467	3.923540e-02	8.961692e-02	6	17805475	17805615	141	-	1.603	1.475	-0.438
ENSG00000137177	E033	28.4300093	0.0008115439	1.141703e-01	2.116238e-01	6	17808768	17808930	163	-	1.502	1.421	-0.278
ENSG00000137177	E034	2.2581022	0.0730708800	7.453452e-01	8.334191e-01	6	17812044	17812610	567	-	0.487	0.580	0.439
ENSG00000137177	E035	36.4355442	0.0006020776	5.353726e-01	6.672285e-01	6	17817020	17817233	214	-	1.577	1.564	-0.044
ENSG00000137177	E036	0.0000000				6	17821786	17821905	120	-
ENSG00000137177	E037	30.6975516	0.0006265003	6.808562e-03	2.072533e-02	6	17825768	17825934	167	-	1.558	1.408	-0.518
ENSG00000137177	E038	22.2607540	0.0009044791	9.227655e-02	1.786837e-01	6	17826038	17826124	87	-	1.408	1.306	-0.353
ENSG00000137177	E039	27.1717972	0.0007338330	9.456181e-01	9.698848e-01	6	17828240	17828370	131	-	1.442	1.460	0.064
ENSG00000137177	E040	34.6370545	0.0005967714	9.574496e-01	9.773318e-01	6	17831101	17831235	135	-	1.539	1.559	0.067
ENSG00000137177	E041	34.9532956	0.0007061174	5.530143e-02	1.185119e-01	6	17833961	17834071	111	-	1.588	1.496	-0.317
ENSG00000137177	E042	51.0815900	0.0004632359	2.130532e-02	5.423217e-02	6	17836878	17837090	213	-	1.751	1.659	-0.310
ENSG00000137177	E043	30.2982767	0.0043263540	3.351809e-02	7.881021e-02	6	17837472	17837583	112	-	1.546	1.421	-0.430
ENSG00000137177	E044	36.8680831	0.0009284801	2.774475e-01	4.170108e-01	6	17849377	17849489	113	-	1.594	1.554	-0.137
ENSG00000137177	E045	32.8160308	0.0006407064	3.854802e-02	8.836357e-02	6	17850323	17850457	135	-	1.571	1.466	-0.358
ENSG00000137177	E046	23.9167142	0.0008052764	2.413854e-02	6.009912e-02	6	17851955	17852042	88	-	1.454	1.315	-0.481
ENSG00000137177	E047	15.3894122	0.0012361483	3.960622e-02	9.030413e-02	6	17855437	17855476	40	-	1.281	1.123	-0.560
ENSG00000137177	E048	25.5809480	0.0190376443	1.779174e-01	2.985203e-01	6	17855477	17855617	141	-	1.469	1.372	-0.335
ENSG00000137177	E049	22.2975902	0.0028466162	4.451705e-02	9.931138e-02	6	17856030	17856122	93	-	1.421	1.288	-0.461
ENSG00000137177	E050	0.1472490	0.0445365996	7.224064e-01		6	17873263	17873376	114	-	0.100	0.000	-8.275
ENSG00000137177	E051	18.7253605	0.0010780037	3.316021e-02	7.812587e-02	6	17873377	17873437	61	-	1.356	1.208	-0.521
ENSG00000137177	E052	12.4886516	0.0014157440	2.525893e-01	3.889608e-01	6	17898168	17898180	13	-	1.168	1.081	-0.310
ENSG00000137177	E053	27.8733569	0.0104329398	3.276756e-03	1.108224e-02	6	17950406	17951429	1024	-	1.331	1.589	0.887
ENSG00000137177	E054	24.8790840	0.0271930714	8.767774e-02	1.716009e-01	6	17987054	17987144	91	-	1.469	1.323	-0.505
ENSG00000137177	E055	14.5241418	0.0592368532	1.355770e-02	3.720905e-02	6	17987409	17987635	227	-	1.303	0.966	-1.213

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000137177

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3