ENSG00000137177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378814 ENSG00000137177 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF13A protein_coding protein_coding 6.327461 5.479567 7.845583 0.4838179 0.3134418 0.5170261 2.6187170 1.7661702 3.3767426 0.31638813 0.29530956 0.93112850 0.40759167 0.31660000 0.42926667 0.11266667 1.733541e-01 1.458963e-18 FALSE TRUE
ENST00000378826 ENSG00000137177 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF13A protein_coding protein_coding 6.327461 5.479567 7.845583 0.4838179 0.3134418 0.5170261 0.3853339 0.3771147 0.3300876 0.08752164 0.17518715 -0.18685456 0.06230000 0.07316667 0.04246667 -0.03070000 6.801967e-01 1.458963e-18 FALSE TRUE
ENST00000502297 ENSG00000137177 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF13A protein_coding protein_coding 6.327461 5.479567 7.845583 0.4838179 0.3134418 0.5170261 1.1107701 1.8559719 0.6633373 0.15295806 0.05686092 -1.47052603 0.19699167 0.34510000 0.08533333 -0.25976667 8.400307e-07 1.458963e-18 FALSE TRUE
ENST00000502704 ENSG00000137177 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF13A protein_coding protein_coding 6.327461 5.479567 7.845583 0.4838179 0.3134418 0.5170261 0.6526063 0.9053330 0.9542370 0.10603033 0.14223977 0.07509117 0.10300000 0.16513333 0.12123333 -0.04390000 4.409136e-01 1.458963e-18   FALSE
ENST00000506044 ENSG00000137177 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF13A protein_coding protein_coding 6.327461 5.479567 7.845583 0.4838179 0.3134418 0.5170261 0.4003634 0.1417426 0.6257665 0.02333196 0.16025694 2.06687047 0.05859167 0.02590000 0.07893333 0.05303333 6.914851e-02 1.458963e-18 FALSE FALSE
MSTRG.27696.2 ENSG00000137177 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF13A protein_coding   6.327461 5.479567 7.845583 0.4838179 0.3134418 0.5170261 0.3705948 0.2519535 0.0000000 0.25195353 0.00000000 -4.71123900 0.05834167 0.04253333 0.00000000 -0.04253333 7.238142e-01 1.458963e-18 FALSE TRUE
MSTRG.27696.4 ENSG00000137177 HEK293_OSMI2_2hA HEK293_TMG_2hB KIF13A protein_coding   6.327461 5.479567 7.845583 0.4838179 0.3134418 0.5170261 0.5042368 0.0000000 1.4400036 0.00000000 0.02389674 7.17991267 0.06953750 0.00000000 0.18433333 0.18433333 1.458963e-18 1.458963e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137177 E001 0.7352249 0.4710244632 6.046590e-01 7.251029e-01 6 17759183 17759253 71 - 0.180 0.335 1.173
ENSG00000137177 E002 170.8432994 0.0071822343 1.448901e-15 5.362243e-14 6 17759254 17760502 1249 - 2.023 2.412 1.299
ENSG00000137177 E003 61.7178542 0.0056361334 2.707826e-04 1.260850e-03 6 17760503 17760877 375 - 1.686 1.916 0.776
ENSG00000137177 E004 0.0000000       6 17763693 17763694 2 -      
ENSG00000137177 E005 6.9622459 0.0126635502 3.681289e-02 8.511010e-02 6 17763695 17764109 415 - 0.752 1.035 1.078
ENSG00000137177 E006 2.4367576 0.1849247145 1.900497e-01 3.138400e-01 6 17764110 17764154 45 - 0.360 0.676 1.536
ENSG00000137177 E007 134.3318865 0.0004446219 1.355223e-01 2.418487e-01 6 17764155 17764946 792 - 2.099 2.168 0.229
ENSG00000137177 E008 0.3289534 0.0292153524 7.680777e-01   6 17770365 17771113 749 - 0.100 0.149 0.664
ENSG00000137177 E009 12.5512911 0.0016987915 9.664172e-01 9.829214e-01 6 17771114 17771218 105 - 1.119 1.137 0.063
ENSG00000137177 E010 0.5943067 0.0247022944 5.387512e-01 6.701392e-01 6 17771219 17771907 689 - 0.249 0.149 -0.924
ENSG00000137177 E011 52.9567672 0.0010510245 9.000079e-01 9.402023e-01 6 17771908 17772059 152 - 1.724 1.740 0.055
ENSG00000137177 E012 47.0818244 0.0005027809 5.686548e-01 6.952742e-01 6 17773478 17773583 106 - 1.684 1.678 -0.020
ENSG00000137177 E013 30.5706903 0.0006918539 5.796530e-01 7.045005e-01 6 17775015 17775062 48 - 1.502 1.490 -0.042
ENSG00000137177 E014 30.0426373 0.0007843758 9.217956e-01 9.546456e-01 6 17777277 17777354 78 - 1.473 1.501 0.098
ENSG00000137177 E015 39.1351479 0.0139217842 9.932953e-01 9.999619e-01 6 17778947 17779099 153 - 1.589 1.605 0.056
ENSG00000137177 E016 32.4456148 0.0138186296 5.954357e-01 7.175367e-01 6 17779592 17779684 93 - 1.530 1.499 -0.106
ENSG00000137177 E017 25.5121317 0.0039676992 6.129177e-01 7.317492e-01 6 17780730 17780759 30 - 1.425 1.408 -0.059
ENSG00000137177 E018 35.3939379 0.0010151067 4.168716e-01 5.602539e-01 6 17780760 17780906 147 - 1.530 1.601 0.243
ENSG00000137177 E019 28.5014516 0.0007175088 4.725685e-01 6.116300e-01 6 17781177 17781301 125 - 1.437 1.507 0.238
ENSG00000137177 E020 16.8667155 0.0069780427 7.789616e-01 8.578068e-01 6 17783646 17783701 56 - 1.232 1.278 0.164
ENSG00000137177 E021 23.2876153 0.0008389485 7.607848e-01 8.447779e-01 6 17785515 17785592 78 - 1.385 1.386 0.004
ENSG00000137177 E022 22.8115106 0.0008669119 8.380534e-01 8.987541e-01 6 17785593 17785641 49 - 1.356 1.394 0.129
ENSG00000137177 E023 34.3726533 0.0014082445 2.605618e-01 3.981052e-01 6 17787776 17787875 100 - 1.565 1.518 -0.161
ENSG00000137177 E024 6.8856028 0.0080148741 2.136370e-01 3.428201e-01 6 17789872 17789910 39 - 0.943 0.801 -0.542
ENSG00000137177 E025 30.6065209 0.0054413591 2.868551e-01 4.272985e-01 6 17794249 17794395 147 - 1.516 1.461 -0.189
ENSG00000137177 E026 34.0182118 0.0135138972 3.412889e-01 4.852026e-01 6 17794572 17794704 133 - 1.562 1.500 -0.212
ENSG00000137177 E027 0.0000000       6 17794860 17795032 173 -      
ENSG00000137177 E028 35.0516727 0.0008851507 3.044475e-01 4.464520e-01 6 17796669 17796820 152 - 1.568 1.529 -0.133
ENSG00000137177 E029 39.1760046 0.0005658499 2.327524e-01 3.657089e-01 6 17799266 17799439 174 - 1.622 1.578 -0.149
ENSG00000137177 E030 39.6174443 0.0006765619 3.057648e-02 7.310033e-02 6 17799952 17800113 162 - 1.648 1.549 -0.337
ENSG00000137177 E031 38.2363966 0.0005823902 2.924851e-03 1.004412e-02 6 17804361 17804510 150 - 1.650 1.501 -0.509
ENSG00000137177 E032 34.4949840 0.0086431467 3.923540e-02 8.961692e-02 6 17805475 17805615 141 - 1.603 1.475 -0.438
ENSG00000137177 E033 28.4300093 0.0008115439 1.141703e-01 2.116238e-01 6 17808768 17808930 163 - 1.502 1.421 -0.278
ENSG00000137177 E034 2.2581022 0.0730708800 7.453452e-01 8.334191e-01 6 17812044 17812610 567 - 0.487 0.580 0.439
ENSG00000137177 E035 36.4355442 0.0006020776 5.353726e-01 6.672285e-01 6 17817020 17817233 214 - 1.577 1.564 -0.044
ENSG00000137177 E036 0.0000000       6 17821786 17821905 120 -      
ENSG00000137177 E037 30.6975516 0.0006265003 6.808562e-03 2.072533e-02 6 17825768 17825934 167 - 1.558 1.408 -0.518
ENSG00000137177 E038 22.2607540 0.0009044791 9.227655e-02 1.786837e-01 6 17826038 17826124 87 - 1.408 1.306 -0.353
ENSG00000137177 E039 27.1717972 0.0007338330 9.456181e-01 9.698848e-01 6 17828240 17828370 131 - 1.442 1.460 0.064
ENSG00000137177 E040 34.6370545 0.0005967714 9.574496e-01 9.773318e-01 6 17831101 17831235 135 - 1.539 1.559 0.067
ENSG00000137177 E041 34.9532956 0.0007061174 5.530143e-02 1.185119e-01 6 17833961 17834071 111 - 1.588 1.496 -0.317
ENSG00000137177 E042 51.0815900 0.0004632359 2.130532e-02 5.423217e-02 6 17836878 17837090 213 - 1.751 1.659 -0.310
ENSG00000137177 E043 30.2982767 0.0043263540 3.351809e-02 7.881021e-02 6 17837472 17837583 112 - 1.546 1.421 -0.430
ENSG00000137177 E044 36.8680831 0.0009284801 2.774475e-01 4.170108e-01 6 17849377 17849489 113 - 1.594 1.554 -0.137
ENSG00000137177 E045 32.8160308 0.0006407064 3.854802e-02 8.836357e-02 6 17850323 17850457 135 - 1.571 1.466 -0.358
ENSG00000137177 E046 23.9167142 0.0008052764 2.413854e-02 6.009912e-02 6 17851955 17852042 88 - 1.454 1.315 -0.481
ENSG00000137177 E047 15.3894122 0.0012361483 3.960622e-02 9.030413e-02 6 17855437 17855476 40 - 1.281 1.123 -0.560
ENSG00000137177 E048 25.5809480 0.0190376443 1.779174e-01 2.985203e-01 6 17855477 17855617 141 - 1.469 1.372 -0.335
ENSG00000137177 E049 22.2975902 0.0028466162 4.451705e-02 9.931138e-02 6 17856030 17856122 93 - 1.421 1.288 -0.461
ENSG00000137177 E050 0.1472490 0.0445365996 7.224064e-01   6 17873263 17873376 114 - 0.100 0.000 -8.275
ENSG00000137177 E051 18.7253605 0.0010780037 3.316021e-02 7.812587e-02 6 17873377 17873437 61 - 1.356 1.208 -0.521
ENSG00000137177 E052 12.4886516 0.0014157440 2.525893e-01 3.889608e-01 6 17898168 17898180 13 - 1.168 1.081 -0.310
ENSG00000137177 E053 27.8733569 0.0104329398 3.276756e-03 1.108224e-02 6 17950406 17951429 1024 - 1.331 1.589 0.887
ENSG00000137177 E054 24.8790840 0.0271930714 8.767774e-02 1.716009e-01 6 17987054 17987144 91 - 1.469 1.323 -0.505
ENSG00000137177 E055 14.5241418 0.0592368532 1.355770e-02 3.720905e-02 6 17987409 17987635 227 - 1.303 0.966 -1.213