ENSG00000137145

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361024 ENSG00000137145 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4C protein_coding protein_coding 4.914302 1.51788 7.473889 0.1201914 0.5333246 2.292257 0.5132799 0.9980513 0.1054570 0.1531803 0.10545699 -3.126142 0.26265000 0.64980000 0.01233333 -0.6374667 3.624168e-05 3.624168e-05 FALSE TRUE
ENST00000434457 ENSG00000137145 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4C protein_coding protein_coding 4.914302 1.51788 7.473889 0.1201914 0.5333246 2.292257 3.4600908 0.2209497 5.8749156 0.1215042 0.09575886 4.671371 0.53013750 0.15310000 0.79450000 0.6414000 3.970593e-03 3.624168e-05 FALSE TRUE
ENST00000602925 ENSG00000137145 HEK293_OSMI2_2hA HEK293_TMG_2hB DENND4C protein_coding protein_coding 4.914302 1.51788 7.473889 0.1201914 0.5333246 2.292257 0.2907505 0.1246685 0.6214934 0.1246685 0.09835979 2.229355 0.05386667 0.08273333 0.08243333 -0.0003000 6.524158e-01 3.624168e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137145 E001 1.5554467 0.0126778800 8.792266e-01 9.264213e-01 9 19230435 19230692 258 + 0.293 0.299 0.036
ENSG00000137145 E002 6.0477960 0.0029292503 1.425006e-01 2.514348e-01 9 19230693 19230796 104 + 0.705 0.474 -1.043
ENSG00000137145 E003 9.3623296 0.0017870515 3.462112e-01 4.903607e-01 9 19230797 19230833 37 + 0.852 0.774 -0.306
ENSG00000137145 E004 38.0803787 0.0005869489 2.354213e-04 1.114356e-03 9 19276158 19276479 322 + 1.430 1.141 -1.014
ENSG00000137145 E005 0.1482932 0.0412412839 4.382845e-02   9 19276480 19276671 192 + 0.000 0.298 13.567
ENSG00000137145 E006 34.7394301 0.0005630014 1.791890e-05 1.123638e-04 9 19286769 19287021 253 + 1.398 0.995 -1.433
ENSG00000137145 E007 15.5717602 0.0011700545 4.287963e-03 1.394889e-02 9 19288596 19288665 70 + 1.069 0.695 -1.439
ENSG00000137145 E008 13.3888738 0.0041323551 8.885735e-04 3.574198e-03 9 19290704 19290757 54 + 1.018 0.474 -2.255
ENSG00000137145 E009 18.3109135 0.0010001882 5.516740e-02 1.182822e-01 9 19290758 19290876 119 + 1.121 0.950 -0.628
ENSG00000137145 E010 27.8606708 0.0020159198 2.963459e-01 4.375416e-01 9 19296008 19296246 239 + 1.274 1.251 -0.082
ENSG00000137145 E011 19.2911798 0.0014639895 2.642323e-01 4.021887e-01 9 19298056 19298122 67 + 1.128 1.075 -0.194
ENSG00000137145 E012 19.0073080 0.0070968946 2.124582e-02 5.410433e-02 9 19299229 19299287 59 + 1.142 0.898 -0.896
ENSG00000137145 E013 24.2369466 0.0008104154 7.074215e-03 2.141903e-02 9 19300187 19300331 145 + 1.241 0.995 -0.883
ENSG00000137145 E014 26.9814205 0.0007439876 1.735409e-03 6.394199e-03 9 19305352 19305527 176 + 1.286 0.995 -1.043
ENSG00000137145 E015 22.2044649 0.0045278986 3.321755e-04 1.509199e-03 9 19316417 19316517 101 + 1.216 0.774 -1.643
ENSG00000137145 E016 30.1044103 0.0006984146 2.326363e-05 1.420723e-04 9 19316621 19316839 219 + 1.340 0.899 -1.595
ENSG00000137145 E017 18.7926289 0.0009562788 4.485149e-02 9.992450e-02 9 19324362 19324507 146 + 1.132 0.950 -0.666
ENSG00000137145 E018 11.3325592 0.0015669152 4.545281e-04 1.984627e-03 9 19325939 19325974 36 + 0.956 0.298 -3.024
ENSG00000137145 E019 22.2771633 0.0011554632 3.057319e-03 1.043472e-02 9 19326064 19326194 131 + 1.207 0.899 -1.127
ENSG00000137145 E020 22.5288120 0.0008728009 7.030413e-03 2.130377e-02 9 19328030 19328162 133 + 1.210 0.950 -0.945
ENSG00000137145 E021 28.8552366 0.0006590247 2.121987e-02 5.405460e-02 9 19331978 19332184 207 + 1.305 1.141 -0.579
ENSG00000137145 E022 0.2924217 0.0290785164 1.000000e+00   9 19332185 19332188 4 + 0.084 0.000 -8.750
ENSG00000137145 E023 19.2026739 0.0010226265 8.241023e-02 1.633076e-01 9 19334977 19335105 129 + 1.135 0.995 -0.508
ENSG00000137145 E024 25.7419544 0.0073014654 2.848207e-02 6.897761e-02 9 19336270 19336403 134 + 1.259 1.075 -0.656
ENSG00000137145 E025 15.1596755 0.0012007418 4.858067e-02 1.066475e-01 9 19336404 19336414 11 + 1.049 0.841 -0.780
ENSG00000137145 E026 2.7553225 0.0084424429 9.373853e-01 9.646317e-01 9 19336415 19336685 271 + 0.434 0.474 0.206
ENSG00000137145 E027 31.4939081 0.0007322943 2.675392e-03 9.299565e-03 9 19336686 19336832 147 + 1.349 1.109 -0.847
ENSG00000137145 E028 0.2903454 0.2767796751 1.000000e+00   9 19337601 19337672 72 + 0.084 0.000 -8.938
ENSG00000137145 E029 33.1762378 0.0488532083 2.734270e-01 4.124657e-01 9 19340992 19341114 123 + 1.355 1.294 -0.213
ENSG00000137145 E030 18.7681339 0.0011529832 4.826257e-01 6.207617e-01 9 19342633 19342668 36 + 1.092 1.250 0.564
ENSG00000137145 E031 29.6076645 0.0006951418 3.615833e-01 5.059799e-01 9 19342669 19342779 111 + 1.300 1.296 -0.015
ENSG00000137145 E032 84.3658239 0.0003215640 1.611447e-06 1.279373e-05 9 19345921 19346555 635 + 1.760 1.526 -0.795
ENSG00000137145 E033 36.6459682 0.0006620862 2.864591e-01 4.268561e-01 9 19346556 19346727 172 + 1.385 1.375 -0.033
ENSG00000137145 E034 55.5513306 0.0129514650 4.407420e-01 5.824144e-01 9 19346728 19347086 359 + 1.540 1.689 0.508
ENSG00000137145 E035 37.6399783 0.0007171199 6.764692e-01 7.814285e-01 9 19350702 19350879 178 + 1.392 1.442 0.172
ENSG00000137145 E036 27.2067828 0.0008101803 6.257837e-01 7.418501e-01 9 19352073 19352182 110 + 1.246 1.375 0.452
ENSG00000137145 E037 29.1966007 0.0006554492 6.521563e-02 1.353918e-01 9 19352490 19352665 176 + 1.259 1.500 0.837
ENSG00000137145 E038 41.1546675 0.0005629120 8.789665e-02 1.719246e-01 9 19356972 19357154 183 + 1.407 1.618 0.723
ENSG00000137145 E039 3.7934751 0.0041924133 5.811958e-03 1.811845e-02 9 19357155 19357695 541 + 0.434 0.950 2.205
ENSG00000137145 E040 44.7559072 0.0008404305 1.353668e-01 2.416246e-01 9 19357965 19358160 196 + 1.446 1.638 0.659
ENSG00000137145 E041 49.1567114 0.0022013874 6.065109e-03 1.878092e-02 9 19360244 19360489 246 + 1.470 1.743 0.931
ENSG00000137145 E042 39.7928670 0.0005372191 5.146430e-02 1.117540e-01 9 19361846 19361963 118 + 1.389 1.618 0.787
ENSG00000137145 E043 45.8366477 0.0005724457 5.744136e-02 1.222474e-01 9 19369837 19369987 151 + 1.449 1.667 0.746
ENSG00000137145 E044 26.7830317 0.0009756603 4.258957e-01 5.687667e-01 9 19371756 19371820 65 + 1.235 1.393 0.551
ENSG00000137145 E045 207.4043536 0.0244142331 1.749419e-08 2.062494e-07 9 19372037 19374281 2245 + 2.038 2.510 1.577