ENSG00000137145

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000361024	ENSG00000137145	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DENND4C	protein_coding	protein_coding	4.914302	1.51788	7.473889	0.1201914	0.5333246	2.292257	0.5132799	0.9980513	0.1054570	0.1531803	0.10545699	-3.126142	0.26265000	0.64980000	0.01233333	-0.6374667	3.624168e-05	3.624168e-05	FALSE	TRUE
ENST00000434457	ENSG00000137145	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DENND4C	protein_coding	protein_coding	4.914302	1.51788	7.473889	0.1201914	0.5333246	2.292257	3.4600908	0.2209497	5.8749156	0.1215042	0.09575886	4.671371	0.53013750	0.15310000	0.79450000	0.6414000	3.970593e-03	3.624168e-05	FALSE	TRUE
ENST00000602925	ENSG00000137145	HEK293_OSMI2_2hA	HEK293_TMG_2hB	DENND4C	protein_coding	protein_coding	4.914302	1.51788	7.473889	0.1201914	0.5333246	2.292257	0.2907505	0.1246685	0.6214934	0.1246685	0.09835979	2.229355	0.05386667	0.08273333	0.08243333	-0.0003000	6.524158e-01	3.624168e-05	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000137145	E001	1.5554467	0.0126778800	8.792266e-01	9.264213e-01	9	19230435	19230692	258	+	0.293	0.299	0.036
ENSG00000137145	E002	6.0477960	0.0029292503	1.425006e-01	2.514348e-01	9	19230693	19230796	104	+	0.705	0.474	-1.043
ENSG00000137145	E003	9.3623296	0.0017870515	3.462112e-01	4.903607e-01	9	19230797	19230833	37	+	0.852	0.774	-0.306
ENSG00000137145	E004	38.0803787	0.0005869489	2.354213e-04	1.114356e-03	9	19276158	19276479	322	+	1.430	1.141	-1.014
ENSG00000137145	E005	0.1482932	0.0412412839	4.382845e-02		9	19276480	19276671	192	+	0.000	0.298	13.567
ENSG00000137145	E006	34.7394301	0.0005630014	1.791890e-05	1.123638e-04	9	19286769	19287021	253	+	1.398	0.995	-1.433
ENSG00000137145	E007	15.5717602	0.0011700545	4.287963e-03	1.394889e-02	9	19288596	19288665	70	+	1.069	0.695	-1.439
ENSG00000137145	E008	13.3888738	0.0041323551	8.885735e-04	3.574198e-03	9	19290704	19290757	54	+	1.018	0.474	-2.255
ENSG00000137145	E009	18.3109135	0.0010001882	5.516740e-02	1.182822e-01	9	19290758	19290876	119	+	1.121	0.950	-0.628
ENSG00000137145	E010	27.8606708	0.0020159198	2.963459e-01	4.375416e-01	9	19296008	19296246	239	+	1.274	1.251	-0.082
ENSG00000137145	E011	19.2911798	0.0014639895	2.642323e-01	4.021887e-01	9	19298056	19298122	67	+	1.128	1.075	-0.194
ENSG00000137145	E012	19.0073080	0.0070968946	2.124582e-02	5.410433e-02	9	19299229	19299287	59	+	1.142	0.898	-0.896
ENSG00000137145	E013	24.2369466	0.0008104154	7.074215e-03	2.141903e-02	9	19300187	19300331	145	+	1.241	0.995	-0.883
ENSG00000137145	E014	26.9814205	0.0007439876	1.735409e-03	6.394199e-03	9	19305352	19305527	176	+	1.286	0.995	-1.043
ENSG00000137145	E015	22.2044649	0.0045278986	3.321755e-04	1.509199e-03	9	19316417	19316517	101	+	1.216	0.774	-1.643
ENSG00000137145	E016	30.1044103	0.0006984146	2.326363e-05	1.420723e-04	9	19316621	19316839	219	+	1.340	0.899	-1.595
ENSG00000137145	E017	18.7926289	0.0009562788	4.485149e-02	9.992450e-02	9	19324362	19324507	146	+	1.132	0.950	-0.666
ENSG00000137145	E018	11.3325592	0.0015669152	4.545281e-04	1.984627e-03	9	19325939	19325974	36	+	0.956	0.298	-3.024
ENSG00000137145	E019	22.2771633	0.0011554632	3.057319e-03	1.043472e-02	9	19326064	19326194	131	+	1.207	0.899	-1.127
ENSG00000137145	E020	22.5288120	0.0008728009	7.030413e-03	2.130377e-02	9	19328030	19328162	133	+	1.210	0.950	-0.945
ENSG00000137145	E021	28.8552366	0.0006590247	2.121987e-02	5.405460e-02	9	19331978	19332184	207	+	1.305	1.141	-0.579
ENSG00000137145	E022	0.2924217	0.0290785164	1.000000e+00		9	19332185	19332188	4	+	0.084	0.000	-8.750
ENSG00000137145	E023	19.2026739	0.0010226265	8.241023e-02	1.633076e-01	9	19334977	19335105	129	+	1.135	0.995	-0.508
ENSG00000137145	E024	25.7419544	0.0073014654	2.848207e-02	6.897761e-02	9	19336270	19336403	134	+	1.259	1.075	-0.656
ENSG00000137145	E025	15.1596755	0.0012007418	4.858067e-02	1.066475e-01	9	19336404	19336414	11	+	1.049	0.841	-0.780
ENSG00000137145	E026	2.7553225	0.0084424429	9.373853e-01	9.646317e-01	9	19336415	19336685	271	+	0.434	0.474	0.206
ENSG00000137145	E027	31.4939081	0.0007322943	2.675392e-03	9.299565e-03	9	19336686	19336832	147	+	1.349	1.109	-0.847
ENSG00000137145	E028	0.2903454	0.2767796751	1.000000e+00		9	19337601	19337672	72	+	0.084	0.000	-8.938
ENSG00000137145	E029	33.1762378	0.0488532083	2.734270e-01	4.124657e-01	9	19340992	19341114	123	+	1.355	1.294	-0.213
ENSG00000137145	E030	18.7681339	0.0011529832	4.826257e-01	6.207617e-01	9	19342633	19342668	36	+	1.092	1.250	0.564
ENSG00000137145	E031	29.6076645	0.0006951418	3.615833e-01	5.059799e-01	9	19342669	19342779	111	+	1.300	1.296	-0.015
ENSG00000137145	E032	84.3658239	0.0003215640	1.611447e-06	1.279373e-05	9	19345921	19346555	635	+	1.760	1.526	-0.795
ENSG00000137145	E033	36.6459682	0.0006620862	2.864591e-01	4.268561e-01	9	19346556	19346727	172	+	1.385	1.375	-0.033
ENSG00000137145	E034	55.5513306	0.0129514650	4.407420e-01	5.824144e-01	9	19346728	19347086	359	+	1.540	1.689	0.508
ENSG00000137145	E035	37.6399783	0.0007171199	6.764692e-01	7.814285e-01	9	19350702	19350879	178	+	1.392	1.442	0.172
ENSG00000137145	E036	27.2067828	0.0008101803	6.257837e-01	7.418501e-01	9	19352073	19352182	110	+	1.246	1.375	0.452
ENSG00000137145	E037	29.1966007	0.0006554492	6.521563e-02	1.353918e-01	9	19352490	19352665	176	+	1.259	1.500	0.837
ENSG00000137145	E038	41.1546675	0.0005629120	8.789665e-02	1.719246e-01	9	19356972	19357154	183	+	1.407	1.618	0.723
ENSG00000137145	E039	3.7934751	0.0041924133	5.811958e-03	1.811845e-02	9	19357155	19357695	541	+	0.434	0.950	2.205
ENSG00000137145	E040	44.7559072	0.0008404305	1.353668e-01	2.416246e-01	9	19357965	19358160	196	+	1.446	1.638	0.659
ENSG00000137145	E041	49.1567114	0.0022013874	6.065109e-03	1.878092e-02	9	19360244	19360489	246	+	1.470	1.743	0.931
ENSG00000137145	E042	39.7928670	0.0005372191	5.146430e-02	1.117540e-01	9	19361846	19361963	118	+	1.389	1.618	0.787
ENSG00000137145	E043	45.8366477	0.0005724457	5.744136e-02	1.222474e-01	9	19369837	19369987	151	+	1.449	1.667	0.746
ENSG00000137145	E044	26.7830317	0.0009756603	4.258957e-01	5.687667e-01	9	19371756	19371820	65	+	1.235	1.393	0.551
ENSG00000137145	E045	207.4043536	0.0244142331	1.749419e-08	2.062494e-07	9	19372037	19374281	2245	+	2.038	2.510	1.577

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000137145

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3