ENSG00000137135

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378387 ENSG00000137135 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF39 protein_coding protein_coding 22.23305 26.90628 16.32987 1.033371 0.529863 -0.7200825 2.151839 3.042772 1.754871 0.1803065 0.10803466 -0.790557 0.09597083 0.11293333 0.1080 -0.004933333 9.227133e-01 1.193966e-08 FALSE TRUE
ENST00000468876 ENSG00000137135 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF39 protein_coding processed_transcript 22.23305 26.90628 16.32987 1.033371 0.529863 -0.7200825 3.402313 2.145791 3.842122 0.1396212 0.42570713 0.837436 0.16217083 0.07973333 0.2349 0.155166667 1.193966e-08 1.193966e-08 FALSE FALSE
ENST00000490970 ENSG00000137135 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF39 protein_coding processed_transcript 22.23305 26.90628 16.32987 1.033371 0.529863 -0.7200825 3.918907 4.734238 1.840395 0.5560321 0.09839198 -1.358343 0.17310000 0.17556667 0.1126 -0.062966667 5.396395e-02 1.193966e-08 TRUE FALSE
MSTRG.32627.1 ENSG00000137135 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF39 protein_coding   22.23305 26.90628 16.32987 1.033371 0.529863 -0.7200825 7.872435 10.205831 4.740955 0.9382427 0.31645084 -1.104517 0.34844583 0.37803333 0.2919 -0.086133333 2.444969e-01 1.193966e-08 TRUE TRUE
MSTRG.32627.8 ENSG00000137135 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF39 protein_coding   22.23305 26.90628 16.32987 1.033371 0.529863 -0.7200825 1.555964 2.424013 1.177226 0.3867563 0.24037029 -1.035743 0.06967500 0.08933333 0.0732 -0.016133333 7.442678e-01 1.193966e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137135 E001 0.0000000       9 35658752 35658774 23 -      
ENSG00000137135 E002 0.0000000       9 35658775 35658799 25 -      
ENSG00000137135 E003 0.0000000       9 35658800 35658802 3 -      
ENSG00000137135 E004 0.0000000       9 35658803 35658874 72 -      
ENSG00000137135 E005 0.6934950 0.0731108163 4.920948e-01 6.293039e-01 9 35658875 35658876 2 - 0.288 0.162 -1.062
ENSG00000137135 E006 1.2836490 0.0802704372 1.201240e-01 2.201691e-01 9 35658877 35658877 1 - 0.526 0.224 -1.804
ENSG00000137135 E007 137.2555670 0.0008064603 2.624918e-02 6.445168e-02 9 35658878 35659173 296 - 2.036 2.115 0.266
ENSG00000137135 E008 52.6256757 0.0004277735 9.409207e-01 9.668510e-01 9 35659343 35660093 751 - 1.687 1.684 -0.009
ENSG00000137135 E009 401.2788862 0.0009482258 1.634324e-01 2.796251e-01 9 35660094 35660967 874 - 2.533 2.566 0.109
ENSG00000137135 E010 251.5467227 0.0013864226 2.104636e-01 3.390810e-01 9 35660968 35661518 551 - 2.378 2.344 -0.112
ENSG00000137135 E011 121.3355974 0.0002646683 1.849552e-07 1.783983e-06 9 35661519 35661712 194 - 1.892 2.086 0.654
ENSG00000137135 E012 165.3956625 0.0040606642 8.495019e-02 1.673258e-01 9 35661713 35661837 125 - 2.121 2.197 0.253
ENSG00000137135 E013 243.7408814 0.0005525305 6.403012e-01 7.535761e-01 9 35661838 35661999 162 - 2.352 2.342 -0.034
ENSG00000137135 E014 101.5867958 0.0003309843 6.247762e-01 7.410364e-01 9 35662000 35662002 3 - 1.979 1.962 -0.058
ENSG00000137135 E015 154.3734075 0.0003132327 1.719500e-01 2.907387e-01 9 35662179 35662227 49 - 2.175 2.135 -0.135
ENSG00000137135 E016 120.7643717 0.0013651397 5.138482e-02 1.116147e-01 9 35662228 35662267 40 - 2.092 2.021 -0.238
ENSG00000137135 E017 218.1449053 0.0065764581 3.911381e-01 5.350717e-01 9 35662512 35662741 230 - 2.267 2.308 0.138
ENSG00000137135 E018 71.4925878 0.0003913318 2.823603e-01 4.223533e-01 9 35662946 35662966 21 - 1.781 1.832 0.170
ENSG00000137135 E019 126.3751652 0.0019814441 2.069490e-01 3.348928e-01 9 35662967 35663074 108 - 2.094 2.047 -0.158
ENSG00000137135 E020 24.7372718 0.0104490629 1.230859e-08 1.492846e-07 9 35663075 35663239 165 - 1.648 1.174 -1.642
ENSG00000137135 E021 31.1603362 0.0101524501 8.483678e-05 4.509434e-04 9 35663240 35663321 82 - 1.657 1.350 -1.052
ENSG00000137135 E022 153.5366137 0.0007586142 2.110324e-01 3.397505e-01 9 35663322 35663392 71 - 2.172 2.134 -0.129
ENSG00000137135 E023 161.3868529 0.0002111779 1.357206e-01 2.421124e-01 9 35664008 35664126 119 - 2.194 2.151 -0.143
ENSG00000137135 E024 147.7811502 0.0020885282 7.854256e-01 8.624736e-01 9 35664372 35664492 121 - 2.115 2.126 0.038
ENSG00000137135 E025 97.8673872 0.0096428728 6.394160e-01 7.528149e-01 9 35664756 35664850 95 - 1.922 1.954 0.110
ENSG00000137135 E026 95.3435501 0.0016850853 2.822501e-01 4.222219e-01 9 35665032 35665217 186 - 1.899 1.947 0.161
ENSG00000137135 E027 0.0000000       9 35669584 35669708 125 -      
ENSG00000137135 E028 0.1817044 0.0400610486 1.000000e+00   9 35673811 35675866 2056 - 0.001 0.088 7.568