ENSG00000137103

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000439587 ENSG00000137103 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM8B protein_coding protein_coding 11.67486 16.07631 8.050225 0.8110527 0.1731671 -0.9969416 5.638237 8.808982 3.340226 0.5301993 0.1607704 -1.3963537 0.4722792 0.5474667 0.4155000 -0.13196667 0.007020323 0.006657836 FALSE TRUE
ENST00000473947 ENSG00000137103 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM8B protein_coding processed_transcript 11.67486 16.07631 8.050225 0.8110527 0.1731671 -0.9969416 2.395854 3.203363 1.497556 0.2059156 0.3466275 -1.0918725 0.2059167 0.1990667 0.1851333 -0.01393333 0.891632301 0.006657836 FALSE FALSE
MSTRG.32644.13 ENSG00000137103 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM8B protein_coding   11.67486 16.07631 8.050225 0.8110527 0.1731671 -0.9969416 2.086019 2.174973 1.968763 0.1854043 0.1747755 -0.1430171 0.1863125 0.1358333 0.2443000 0.10846667 0.006657836 0.006657836 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137103 E001 1.5541990 0.0091686584 7.293960e-02 1.482246e-01 9 35814451 35815324 874 + 0.583 0.278 -1.655
ENSG00000137103 E002 0.8082883 0.0310522627 1.045937e-01 1.975039e-01 9 35816144 35816234 91 + 0.000 0.326 11.264
ENSG00000137103 E003 0.1817044 0.0392851739 1.000000e+00   9 35829228 35829231 4 + 0.000 0.088 8.955
ENSG00000137103 E004 0.1817044 0.0392851739 1.000000e+00   9 35829232 35829240 9 + 0.000 0.088 8.955
ENSG00000137103 E005 2.0585246 0.0072966658 5.989105e-01 7.204233e-01 9 35829241 35829271 31 + 0.383 0.480 0.517
ENSG00000137103 E006 6.8526705 0.0024219156 6.096975e-01 7.291315e-01 9 35829272 35829298 27 + 0.791 0.863 0.281
ENSG00000137103 E007 8.7004331 0.0039255043 6.087228e-01 7.283747e-01 9 35829299 35829319 21 + 0.881 0.949 0.257
ENSG00000137103 E008 7.6746779 0.0023132601 8.996034e-01 9.399341e-01 9 35829320 35829391 72 + 0.881 0.901 0.078
ENSG00000137103 E009 4.9393448 0.0117346069 9.916540e-01 9.988776e-01 9 35829392 35829497 106 + 0.720 0.723 0.015
ENSG00000137103 E010 2.9475408 0.1550491711 6.412756e-01 7.543461e-01 9 35829498 35829515 18 + 0.461 0.579 0.565
ENSG00000137103 E011 35.2820957 0.0006143776 8.751534e-01 9.237942e-01 9 35829516 35829696 181 + 1.513 1.509 -0.015
ENSG00000137103 E012 47.3009651 0.0015272080 2.852911e-01 4.256047e-01 9 35829697 35829776 80 + 1.674 1.620 -0.182
ENSG00000137103 E013 65.8081086 0.0004828699 2.034589e-01 3.305427e-01 9 35829777 35829876 100 + 1.814 1.761 -0.178
ENSG00000137103 E014 68.4507305 0.0047176848 8.335150e-01 8.957097e-01 9 35829877 35829955 79 + 1.774 1.795 0.070
ENSG00000137103 E015 94.2925793 0.0003239751 1.222473e-01 2.231476e-01 9 35834461 35834648 188 + 1.968 1.915 -0.179
ENSG00000137103 E016 34.3354624 0.0062215033 6.162823e-01 7.343769e-01 9 35834649 35834650 2 + 1.525 1.496 -0.100
ENSG00000137103 E017 96.2046052 0.0003221632 4.633728e-02 1.026466e-01 9 35835011 35835218 208 + 1.990 1.920 -0.232
ENSG00000137103 E018 3.1614127 0.0053527974 6.594294e-01 7.682556e-01 9 35835288 35835441 154 + 0.633 0.568 -0.291
ENSG00000137103 E019 88.8196629 0.0029365886 3.293730e-01 4.728752e-01 9 35841134 35841267 134 + 1.929 1.891 -0.126
ENSG00000137103 E020 109.1425300 0.0049328486 9.165209e-01 9.512421e-01 9 35841526 35841794 269 + 1.981 1.995 0.048
ENSG00000137103 E021 135.8384443 0.0003044147 9.285177e-01 9.590279e-01 9 35842392 35842717 326 + 2.080 2.089 0.029
ENSG00000137103 E022 97.1151668 0.0003529130 2.712572e-01 4.099823e-01 9 35845975 35846068 94 + 1.909 1.958 0.163
ENSG00000137103 E023 2.9077869 0.0078288053 5.437136e-01 6.742703e-01 9 35846069 35846257 189 + 0.460 0.569 0.520
ENSG00000137103 E024 100.0433267 0.0088270109 3.080406e-02 7.353516e-02 9 35846258 35846381 124 + 1.858 1.991 0.446
ENSG00000137103 E025 106.2110154 0.0030889943 1.865914e-04 9.062032e-04 9 35846469 35846611 143 + 1.847 2.026 0.604
ENSG00000137103 E026 118.5049024 0.0024688690 5.996400e-02 1.265484e-01 9 35846817 35846995 179 + 1.970 2.055 0.285
ENSG00000137103 E027 72.0230149 0.0003972561 8.522022e-07 7.185328e-06 9 35846996 35847235 240 + 1.628 1.873 0.830
ENSG00000137103 E028 22.1231170 0.0008727698 1.579459e-01 2.723955e-01 9 35852827 35852973 147 + 1.390 1.288 -0.355
ENSG00000137103 E029 23.8404546 0.0007940394 3.871260e-01 5.312760e-01 9 35853141 35853257 117 + 1.390 1.331 -0.204
ENSG00000137103 E030 10.8558594 0.0016435380 6.282283e-01 7.437986e-01 9 35853505 35853508 4 + 1.056 1.009 -0.169
ENSG00000137103 E031 61.7310070 0.0006090712 9.562855e-02 1.838347e-01 9 35853509 35853979 471 + 1.804 1.731 -0.247
ENSG00000137103 E032 37.1515967 0.0006038938 7.111031e-01 8.081028e-01 9 35853980 35854112 133 + 1.549 1.532 -0.059
ENSG00000137103 E033 129.8361539 0.0002609496 7.633652e-05 4.106694e-04 9 35854113 35860780 6668 + 2.152 2.032 -0.400
ENSG00000137103 E034 25.4570380 0.0008630557 3.662683e-03 1.219030e-02 9 35860781 35865518 4738 + 1.507 1.308 -0.686