ENSG00000137075

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350199 ENSG00000137075 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF38 protein_coding protein_coding 8.151684 6.173548 11.02846 0.6478842 0.09588524 0.8360322 1.8310190 0.4855456 2.7673027 0.04466688 0.7389635 2.486595 0.21158750 0.08056667 0.25046667 0.1699000 4.303354e-02 1.006803e-06 FALSE TRUE
ENST00000353739 ENSG00000137075 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF38 protein_coding protein_coding 8.151684 6.173548 11.02846 0.6478842 0.09588524 0.8360322 1.7031576 2.8758789 0.8518776 0.53113842 0.6393574 -1.743456 0.27116667 0.45856667 0.07653333 -0.3820333 9.475165e-02 1.006803e-06 FALSE TRUE
ENST00000357058 ENSG00000137075 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF38 protein_coding protein_coding 8.151684 6.173548 11.02846 0.6478842 0.09588524 0.8360322 0.4829973 0.1420817 0.7843848 0.02889744 0.1335663 2.384992 0.05097917 0.02276667 0.07116667 0.0484000 2.255508e-02 1.006803e-06 FALSE TRUE
ENST00000377885 ENSG00000137075 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF38 protein_coding protein_coding 8.151684 6.173548 11.02846 0.6478842 0.09588524 0.8360322 2.1363260 2.4255776 2.7682510 0.20929201 1.4598725 0.189913 0.26226250 0.39676667 0.25243333 -0.1443333 7.576526e-01 1.006803e-06 FALSE TRUE
MSTRG.32654.7 ENSG00000137075 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF38 protein_coding   8.151684 6.173548 11.02846 0.6478842 0.09588524 0.8360322 1.1880553 0.1473922 2.4863400 0.04663537 0.2107879 3.987379 0.12093333 0.02586667 0.22580000 0.1999333 1.006803e-06 1.006803e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000137075 E001 0.2214452 0.0423458067 3.120358e-01   9 36336396 36336399 4 - 0.000 0.161 9.793
ENSG00000137075 E002 0.3697384 0.0274424043 1.043194e-01 1.970644e-01 9 36336400 36336403 4 - 0.000 0.278 13.215
ENSG00000137075 E003 121.9175195 0.0097157716 3.617552e-17 1.640043e-15 9 36336404 36336869 466 - 1.775 2.337 1.886
ENSG00000137075 E004 409.0668294 0.0082474241 5.113431e-10 7.988161e-09 9 36336870 36338194 1325 - 2.452 2.768 1.051
ENSG00000137075 E005 270.0234964 0.0009779910 2.083397e-02 5.323980e-02 9 36338195 36339444 1250 - 2.413 2.440 0.090
ENSG00000137075 E006 62.2483422 0.0050364898 4.486520e-06 3.228804e-05 9 36339445 36339580 136 - 1.852 1.663 -0.638
ENSG00000137075 E007 92.3086500 0.0106157971 3.057823e-03 1.043625e-02 9 36339581 36339814 234 - 1.999 1.890 -0.366
ENSG00000137075 E008 55.4568629 0.0100780640 3.939841e-01 5.378930e-01 9 36342325 36342424 100 - 1.735 1.752 0.058
ENSG00000137075 E009 58.7329675 0.0004655701 2.370713e-01 3.707943e-01 9 36344832 36344953 122 - 1.755 1.783 0.095
ENSG00000137075 E010 53.7922685 0.0005234182 1.046785e-01 1.976344e-01 9 36351115 36351199 85 - 1.725 1.729 0.012
ENSG00000137075 E011 52.8766239 0.0037081460 7.218182e-02 1.469711e-01 9 36352742 36352848 107 - 1.729 1.706 -0.077
ENSG00000137075 E012 64.6794832 0.0072920287 6.924489e-04 2.871454e-03 9 36353170 36353331 162 - 1.854 1.724 -0.439
ENSG00000137075 E013 38.5352772 0.0007517827 2.567471e-05 1.552059e-04 9 36356303 36356339 37 - 1.647 1.480 -0.573
ENSG00000137075 E014 53.7936426 0.0053394530 3.766821e-05 2.185377e-04 9 36356340 36356473 134 - 1.791 1.627 -0.555
ENSG00000137075 E015 49.2361295 0.0005677138 2.364745e-05 1.442350e-04 9 36357775 36357942 168 - 1.744 1.607 -0.464
ENSG00000137075 E016 19.7565790 0.0009726122 1.393593e-01 2.471689e-01 9 36369719 36369722 4 - 1.323 1.288 -0.123
ENSG00000137075 E017 57.5174189 0.0124857075 3.439219e-02 8.050781e-02 9 36369723 36369932 210 - 1.785 1.707 -0.263
ENSG00000137075 E018 0.1817044 0.0438013906 3.123679e-01   9 36372496 36372593 98 - 0.000 0.161 12.069
ENSG00000137075 E019 39.8429757 0.0026195346 5.144038e-06 3.650581e-05 9 36375934 36376007 74 - 1.668 1.460 -0.709
ENSG00000137075 E020 42.1439412 0.0009109085 4.736106e-08 5.134427e-07 9 36376008 36376127 120 - 1.699 1.460 -0.817
ENSG00000137075 E021 10.6481835 0.0197000931 1.176471e-01 2.165850e-01 9 36390467 36390553 87 - 1.099 0.979 -0.436
ENSG00000137075 E022 8.0679777 0.0022675190 2.505364e-03 8.779270e-03 9 36390554 36390616 63 - 1.038 0.740 -1.141
ENSG00000137075 E023 1.3629402 0.0096457222 4.850196e-03 1.551534e-02 9 36400097 36400299 203 - 0.092 0.617 3.735
ENSG00000137075 E024 10.6396583 0.0017057327 3.752919e-04 1.678461e-03 9 36400554 36400923 370 - 1.153 0.835 -1.178
ENSG00000137075 E025 3.3415889 0.0054660560 9.635896e-03 2.787138e-02 9 36400936 36401097 162 - 0.739 0.370 -1.735
ENSG00000137075 E026 1.4359811 0.3632574064 5.897945e-01 7.128172e-01 9 36401098 36401198 101 - 0.338 0.444 0.598
ENSG00000137075 E027 6.1635183 0.0072970247 4.721584e-03 1.515468e-02 9 36424613 36424683 71 - 0.944 0.617 -1.307
ENSG00000137075 E028 5.5476693 0.0029247773 1.061356e-03 4.171160e-03 9 36487308 36487620 313 - 0.920 0.511 -1.703