ENSG00000136997

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377970 ENSG00000136997 HEK293_OSMI2_2hA HEK293_TMG_2hB MYC protein_coding protein_coding 59.96957 63.56154 61.59162 0.7246586 2.059757 -0.04541278 10.881036 9.974036 13.823233 2.590082 1.4139351 0.4704433 0.1870750 0.1572667 0.22596667 0.06870000 0.52990431 0.02654476 FALSE TRUE
ENST00000520751 ENSG00000136997 HEK293_OSMI2_2hA HEK293_TMG_2hB MYC protein_coding processed_transcript 59.96957 63.56154 61.59162 0.7246586 2.059757 -0.04541278 5.786216 4.393131 5.363372 1.788246 0.2772339 0.2872982 0.0948375 0.0687000 0.08723333 0.01853333 0.73513653 0.02654476 FALSE FALSE
ENST00000524013 ENSG00000136997 HEK293_OSMI2_2hA HEK293_TMG_2hB MYC protein_coding protein_coding 59.96957 63.56154 61.59162 0.7246586 2.059757 -0.04541278 7.254366 8.039212 6.470407 1.347441 0.3204887 -0.3127632 0.1208292 0.1266333 0.10523333 -0.02140000 0.76688843 0.02654476 FALSE TRUE
ENST00000621592 ENSG00000136997 HEK293_OSMI2_2hA HEK293_TMG_2hB MYC protein_coding protein_coding 59.96957 63.56154 61.59162 0.7246586 2.059757 -0.04541278 20.088112 25.631190 17.092533 1.238678 1.7957539 -0.5842532 0.3347792 0.4034000 0.27693333 -0.12646667 0.02654476 0.02654476 FALSE TRUE
ENST00000641036 ENSG00000136997 HEK293_OSMI2_2hA HEK293_TMG_2hB MYC protein_coding protein_coding 59.96957 63.56154 61.59162 0.7246586 2.059757 -0.04541278 15.578583 15.259039 18.575950 1.413559 1.9689819 0.2836032 0.2565917 0.2398333 0.30026667 0.06043333 0.35195289 0.02654476   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136997 E001 0.2934659 0.0290818349 8.659682e-01   8 127735434 127735472 39 + 0.132 0.113 -0.253
ENSG00000136997 E002 0.7363563 0.0286825561 4.324896e-01 5.749301e-01 8 127735473 127735518 46 + 0.132 0.278 1.339
ENSG00000136997 E003 0.7363563 0.0286825561 4.324896e-01 5.749301e-01 8 127735519 127735537 19 + 0.132 0.278 1.339
ENSG00000136997 E004 1.6189174 0.2396707401 9.576875e-01 9.774694e-01 8 127735538 127735658 121 + 0.383 0.407 0.135
ENSG00000136997 E005 2.4346693 0.1634361960 7.199258e-01 8.146250e-01 8 127735659 127735836 178 + 0.542 0.499 -0.205
ENSG00000136997 E006 0.9201370 0.0137832603 2.579978e-01 3.951980e-01 8 127735837 127736045 209 + 0.132 0.341 1.752
ENSG00000136997 E007 27.7814261 0.0237119438 4.236184e-01 5.666762e-01 8 127736046 127736083 38 + 1.483 1.422 -0.212
ENSG00000136997 E008 92.4858907 0.0099408277 2.790037e-02 6.781419e-02 8 127736084 127736146 63 + 2.027 1.911 -0.388
ENSG00000136997 E009 134.5830346 0.0008786456 1.457469e-05 9.323737e-05 8 127736147 127736219 73 + 2.191 2.071 -0.403
ENSG00000136997 E010 92.4516762 0.0003370229 5.780068e-04 2.452390e-03 8 127736220 127736230 11 + 2.021 1.918 -0.347
ENSG00000136997 E011 436.6948305 0.0001943486 7.656345e-02 1.539926e-01 8 127736231 127736440 210 + 2.638 2.631 -0.025
ENSG00000136997 E012 563.2177193 0.0001918185 3.110359e-01 4.534771e-01 8 127736441 127736623 183 + 2.739 2.747 0.027
ENSG00000136997 E013 1.5845003 0.0226083608 5.074578e-01 6.429751e-01 8 127737621 127737686 66 + 0.315 0.446 0.754
ENSG00000136997 E014 186.0497970 0.0003115706 2.344403e-01 3.676870e-01 8 127738248 127738250 3 + 2.268 2.260 -0.027
ENSG00000136997 E015 296.4160256 0.0013121245 2.051774e-01 3.326378e-01 8 127738251 127738279 29 + 2.471 2.461 -0.034
ENSG00000136997 E016 248.7552599 0.0014242665 1.209598e-01 2.213178e-01 8 127738280 127738291 12 + 2.401 2.381 -0.069
ENSG00000136997 E017 1591.6543254 0.0006966347 5.614870e-01 6.892907e-01 8 127738292 127739019 728 + 3.187 3.201 0.049
ENSG00000136997 E018 368.3561662 0.0002142624 5.741436e-03 1.793165e-02 8 127740396 127740397 2 + 2.579 2.551 -0.095
ENSG00000136997 E019 2661.8488113 0.0016570585 5.908505e-04 2.500200e-03 8 127740398 127742951 2554 + 3.376 3.446 0.234