ENSG00000136937

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375147 ENSG00000136937 HEK293_OSMI2_2hA HEK293_TMG_2hB NCBP1 protein_coding protein_coding 29.9536 11.69029 41.66738 1.193453 0.5366214 1.83272 9.6736874 5.235154 13.05850148 0.6798361 0.36256240 1.317037 0.3628708 0.44636667 0.3132667 -0.13310000 0.0003534689 0.0003534689 FALSE TRUE
MSTRG.33113.10 ENSG00000136937 HEK293_OSMI2_2hA HEK293_TMG_2hB NCBP1 protein_coding   29.9536 11.69029 41.66738 1.193453 0.5366214 1.83272 0.3472543 0.938402 0.04817574 0.9384020 0.04817574 -4.027009 0.0205000 0.06773333 0.0012000 -0.06653333 0.7935440386 0.0003534689 TRUE TRUE
MSTRG.33113.2 ENSG00000136937 HEK293_OSMI2_2hA HEK293_TMG_2hB NCBP1 protein_coding   29.9536 11.69029 41.66738 1.193453 0.5366214 1.83272 19.0134147 5.157531 27.63266956 0.7583780 0.33218064 2.419350 0.5761250 0.45523333 0.6632000 0.20796667 0.1369013521 0.0003534689 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136937 E001 17.388031 0.0010422399 1.872260e-01 3.102480e-01 9 97633526 97633628 103 + 1.253 1.141 -0.396
ENSG00000136937 E002 17.933955 0.0089211662 7.967851e-02 1.590489e-01 9 97633629 97633667 39 + 1.280 1.105 -0.620
ENSG00000136937 E003 32.189871 0.0147790784 7.761552e-03 2.317858e-02 9 97633668 97633776 109 + 1.539 1.289 -0.865
ENSG00000136937 E004 41.628179 0.0005716321 4.068502e-06 2.953237e-05 9 97633777 97633820 44 + 1.657 1.357 -1.029
ENSG00000136937 E005 70.893764 0.0110821523 1.844974e-04 8.971537e-04 9 97633821 97633881 61 + 1.878 1.610 -0.907
ENSG00000136937 E006 72.031270 0.0007066208 4.249378e-06 3.071234e-05 9 97633882 97633915 34 + 1.877 1.654 -0.755
ENSG00000136937 E007 108.155602 0.0006154044 1.105248e-08 1.351661e-07 9 97640794 97640882 89 + 2.052 1.821 -0.776
ENSG00000136937 E008 134.592102 0.0002425624 5.805002e-09 7.492439e-08 9 97641562 97641662 101 + 2.141 1.939 -0.675
ENSG00000136937 E009 221.490436 0.0006721195 2.136255e-08 2.477090e-07 9 97643204 97643360 157 + 2.347 2.189 -0.527
ENSG00000136937 E010 196.914798 0.0001915918 3.707896e-14 1.121050e-12 9 97645117 97645224 108 + 2.309 2.091 -0.732
ENSG00000136937 E011 212.665496 0.0003647402 1.069946e-14 3.502038e-13 9 97645611 97645732 122 + 2.343 2.121 -0.742
ENSG00000136937 E012 162.301712 0.0002021515 1.588081e-09 2.269079e-08 9 97647492 97647561 70 + 2.219 2.032 -0.629
ENSG00000136937 E013 231.849836 0.0002163046 2.251485e-11 4.428726e-10 9 97648008 97648223 216 + 2.370 2.196 -0.581
ENSG00000136937 E014 165.717734 0.0011275085 2.372827e-05 1.446814e-04 9 97650503 97650600 98 + 2.217 2.077 -0.469
ENSG00000136937 E015 142.903081 0.0008793222 1.211978e-04 6.194675e-04 9 97651310 97651373 64 + 2.151 2.020 -0.437
ENSG00000136937 E016 199.528965 0.0001987991 4.173414e-03 1.363103e-02 9 97653798 97653908 111 + 2.281 2.212 -0.232
ENSG00000136937 E017 166.964769 0.0002080534 6.517200e-01 7.625290e-01 9 97654880 97654944 65 + 2.186 2.185 -0.003
ENSG00000136937 E018 134.111990 0.0002431319 6.491533e-01 7.604934e-01 9 97655702 97655764 63 + 2.083 2.112 0.095
ENSG00000136937 E019 163.526180 0.0002119875 4.200659e-02 9.473497e-02 9 97656011 97656085 75 + 2.190 2.139 -0.171
ENSG00000136937 E020 194.299297 0.0002056094 3.220224e-01 4.652911e-01 9 97658640 97658743 104 + 2.256 2.240 -0.051
ENSG00000136937 E021 231.140095 0.0021623855 7.560619e-01 8.412297e-01 9 97660946 97661068 123 + 2.325 2.325 0.000
ENSG00000136937 E022 247.142333 0.0009067993 4.999504e-01 6.362074e-01 9 97662042 97662144 103 + 2.356 2.347 -0.028
ENSG00000136937 E023 240.725599 0.0003842614 2.336321e-01 3.667138e-01 9 97662954 97663047 94 + 2.330 2.374 0.144
ENSG00000136937 E024 237.570546 0.0003634838 5.795917e-01 7.044569e-01 9 97664340 97664443 104 + 2.330 2.357 0.090
ENSG00000136937 E025 244.443389 0.0005666042 4.677484e-01 6.072415e-01 9 97666763 97666877 115 + 2.342 2.374 0.107
ENSG00000136937 E026 311.009933 0.0001785994 6.325712e-06 4.400981e-05 9 97668846 97668974 129 + 2.421 2.532 0.370
ENSG00000136937 E027 245.059541 0.0001909486 7.059441e-12 1.507428e-10 9 97669593 97669706 114 + 2.294 2.472 0.593
ENSG00000136937 E028 3.207602 0.0046781311 7.908558e-01 8.662707e-01 9 97669707 97670076 370 + 0.585 0.638 0.233
ENSG00000136937 E029 188.130586 0.0004072285 1.510533e-19 9.177869e-18 9 97671086 97671201 116 + 2.145 2.409 0.881
ENSG00000136937 E030 85.980540 0.0008759981 7.479563e-13 1.873322e-11 9 97671202 97671223 22 + 1.788 2.094 1.029
ENSG00000136937 E031 223.021608 0.0024918716 6.045556e-08 6.405909e-07 9 97671224 97671495 272 + 2.244 2.442 0.659
ENSG00000136937 E032 373.819290 0.0011147925 3.363455e-02 7.903311e-02 9 97671496 97672667 1172 + 2.515 2.582 0.221
ENSG00000136937 E033 57.016411 0.0004266504 1.775823e-08 2.090501e-07 9 97672668 97672710 43 + 1.623 1.907 0.960
ENSG00000136937 E034 49.984674 0.0004508464 1.642168e-10 2.793426e-09 9 97672711 97672781 71 + 1.541 1.879 1.146
ENSG00000136937 E035 231.032742 0.0058385227 4.042592e-08 4.441552e-07 9 97672782 97673511 730 + 2.236 2.491 0.850
ENSG00000136937 E036 127.847721 0.0094773179 6.319942e-05 3.471122e-04 9 97673512 97674750 1239 + 1.985 2.230 0.822
ENSG00000136937 E037 2.735637 0.0256581675 1.380319e-01 2.453347e-01 9 97675508 97675538 31 + 0.433 0.693 1.202
ENSG00000136937 E038 0.806200 0.1438314551 1.477108e-01 2.585784e-01 9 97683283 97683483 201 + 0.140 0.426 2.134