ENSG00000136925

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341170 ENSG00000136925 HEK293_OSMI2_2hA HEK293_TMG_2hB TSTD2 protein_coding protein_coding 7.35322 4.232255 9.416544 0.1562438 0.3449775 1.151897 4.8954231 2.5675599 6.8314460 0.37908607 0.2029829 1.4082953 0.65477083 0.60283333 0.72890000 0.12606667 0.450887829 0.008184623 FALSE TRUE
ENST00000375163 ENSG00000136925 HEK293_OSMI2_2hA HEK293_TMG_2hB TSTD2 protein_coding retained_intron 7.35322 4.232255 9.416544 0.1562438 0.3449775 1.151897 0.5221780 0.2181228 0.3655370 0.11173294 0.1812322 0.7191442 0.06602500 0.05130000 0.03763333 -0.01366667 0.958624741 0.008184623 FALSE TRUE
ENST00000375165 ENSG00000136925 HEK293_OSMI2_2hA HEK293_TMG_2hB TSTD2 protein_coding nonsense_mediated_decay 7.35322 4.232255 9.416544 0.1562438 0.3449775 1.151897 0.3529323 0.0487432 0.5748792 0.01006475 0.1426704 3.3156451 0.04647083 0.01143333 0.06146667 0.05003333 0.053013445 0.008184623 FALSE TRUE
ENST00000375173 ENSG00000136925 HEK293_OSMI2_2hA HEK293_TMG_2hB TSTD2 protein_coding retained_intron 7.35322 4.232255 9.416544 0.1562438 0.3449775 1.151897 0.9009488 1.3164905 0.7523346 0.32058748 0.1845391 -0.7991181 0.15262083 0.31450000 0.07886667 -0.23563333 0.008184623 0.008184623 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136925 E001 358.9872221 0.0009026211 1.970002e-18 1.046288e-16 9 97600080 97602290 2211 - 2.477 2.634 0.524
ENSG00000136925 E002 93.0885074 0.0019999397 5.792636e-01 7.041968e-01 9 97602291 97602717 427 - 1.947 1.980 0.111
ENSG00000136925 E003 26.5166535 0.0109150163 9.417951e-01 9.674092e-01 9 97602718 97602767 50 - 1.425 1.425 0.001
ENSG00000136925 E004 5.5864161 0.1272916830 4.263611e-01 5.692076e-01 9 97602768 97603155 388 - 0.860 0.682 -0.714
ENSG00000136925 E005 1.0944690 0.0910073606 5.848638e-01 7.086800e-01 9 97603940 97603989 50 - 0.276 0.384 0.678
ENSG00000136925 E006 6.7005556 0.0557061204 1.071299e-02 3.048361e-02 9 97604069 97604726 658 - 0.986 0.529 -1.867
ENSG00000136925 E007 43.6902672 0.0005410737 7.941309e-01 8.684554e-01 9 97604727 97604865 139 - 1.639 1.637 -0.008
ENSG00000136925 E008 49.0911661 0.0004893001 2.883795e-01 4.289588e-01 9 97605483 97605641 159 - 1.703 1.660 -0.146
ENSG00000136925 E009 36.3309202 0.0006067707 1.174856e-01 2.163528e-01 9 97606143 97606261 119 - 1.587 1.504 -0.284
ENSG00000136925 E010 2.4119080 0.0773351956 5.665336e-01 6.934907e-01 9 97610210 97610345 136 - 0.478 0.586 0.506
ENSG00000136925 E011 36.7102102 0.0005437078 1.080603e-01 2.026560e-01 9 97610346 97610451 106 - 1.589 1.504 -0.292
ENSG00000136925 E012 0.5954526 0.0184100463 1.613884e-01 2.768982e-01 9 97610845 97611122 278 - 0.277 0.000 -10.925
ENSG00000136925 E013 37.6291904 0.0006338481 9.505275e-02 1.829487e-01 9 97611574 97611699 126 - 1.599 1.510 -0.304
ENSG00000136925 E014 32.5287888 0.0006775109 9.300871e-03 2.703442e-02 9 97617757 97617877 121 - 1.561 1.402 -0.546
ENSG00000136925 E015 27.1472612 0.0008439750 1.997137e-02 5.142255e-02 9 97625681 97625777 97 - 1.486 1.331 -0.535
ENSG00000136925 E016 40.0317882 0.0008267590 1.543278e-04 7.663678e-04 9 97625778 97625997 220 - 1.667 1.449 -0.745
ENSG00000136925 E017 3.1286645 0.0584794642 4.171129e-04 1.840046e-03 9 97627306 97627397 92 - 0.755 0.000 -12.887
ENSG00000136925 E018 43.5642965 0.0021424931 4.142753e-05 2.379144e-04 9 97627398 97627612 215 - 1.709 1.470 -0.815
ENSG00000136925 E019 23.8392707 0.0008209398 6.481933e-06 4.497940e-05 9 97633243 97633381 139 - 1.480 1.126 -1.239