ENSG00000136878

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315480 ENSG00000136878 HEK293_OSMI2_2hA HEK293_TMG_2hB USP20 protein_coding protein_coding 17.97082 26.24008 10.17029 1.987315 0.4085842 -1.366543 3.125419 4.7814502 2.065663 0.1121407 0.2457169 -1.2068899 0.1786625 0.18386667 0.2028333 0.01896667 8.197288e-01 7.4889e-34 FALSE TRUE
ENST00000372429 ENSG00000136878 HEK293_OSMI2_2hA HEK293_TMG_2hB USP20 protein_coding protein_coding 17.97082 26.24008 10.17029 1.987315 0.4085842 -1.366543 7.351994 10.0953337 4.365387 1.5252955 0.2541294 -1.2076346 0.4122917 0.38170000 0.4291333 0.04743333 6.899110e-01 7.4889e-34 FALSE TRUE
ENST00000491731 ENSG00000136878 HEK293_OSMI2_2hA HEK293_TMG_2hB USP20 protein_coding processed_transcript 17.97082 26.24008 10.17029 1.987315 0.4085842 -1.366543 2.344022 1.9887181 1.749590 0.2900744 0.3415258 -0.1838361 0.1414833 0.07516667 0.1698667 0.09470000 1.117865e-02 7.4889e-34 FALSE TRUE
ENST00000496927 ENSG00000136878 HEK293_OSMI2_2hA HEK293_TMG_2hB USP20 protein_coding processed_transcript 17.97082 26.24008 10.17029 1.987315 0.4085842 -1.366543 3.500144 8.3370781 0.000000 0.7360163 0.0000000 -9.7051275 0.1469958 0.31893333 0.0000000 -0.31893333 7.488900e-34 7.4889e-34 FALSE TRUE
MSTRG.33513.3 ENSG00000136878 HEK293_OSMI2_2hA HEK293_TMG_2hB USP20 protein_coding   17.97082 26.24008 10.17029 1.987315 0.4085842 -1.366543 1.020129 0.4091007 1.112936 0.1053430 0.5924524 1.4219071 0.0761750 0.01560000 0.1127000 0.09710000 6.425947e-01 7.4889e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136878 E001 0.1451727 0.0425200850 1.970426e-01   9 129834698 129835078 381 + 0.176 0.000 -10.527
ENSG00000136878 E002 0.3729606 0.0276998699 5.131687e-01 6.480009e-01 9 129835417 129835445 29 + 0.176 0.084 -1.229
ENSG00000136878 E003 1.6230952 0.0089708439 6.488924e-01 7.602864e-01 9 129835446 129835456 11 + 0.300 0.396 0.578
ENSG00000136878 E004 1.7746106 0.0080581720 9.449186e-01 9.694402e-01 9 129835457 129835457 1 + 0.397 0.396 -0.008
ENSG00000136878 E005 16.0113046 0.0014898300 6.116414e-03 1.891320e-02 9 129835458 129835477 20 + 1.321 1.096 -0.796
ENSG00000136878 E006 30.8913414 0.0008381647 9.630720e-03 2.785683e-02 9 129835478 129835499 22 + 1.549 1.395 -0.531
ENSG00000136878 E007 0.4815130 0.0220787109 8.648246e-01 9.168761e-01 9 129835500 129835597 98 + 0.176 0.154 -0.233
ENSG00000136878 E008 0.8856816 0.1086644447 6.316205e-01 7.465971e-01 9 129849800 129849812 13 + 0.300 0.216 -0.634
ENSG00000136878 E009 61.3353237 0.0004314162 8.835359e-03 2.587027e-02 9 129849813 129849924 112 + 1.812 1.703 -0.366
ENSG00000136878 E010 77.9536231 0.0003797807 9.486760e-04 3.783261e-03 9 129852540 129852636 97 + 1.926 1.803 -0.415
ENSG00000136878 E011 59.6681556 0.0055138906 2.689368e-03 9.342147e-03 9 129856307 129856360 54 + 1.835 1.677 -0.533
ENSG00000136878 E012 63.6962314 0.0024786666 5.992856e-02 1.264891e-01 9 129858050 129858112 63 + 1.805 1.725 -0.270
ENSG00000136878 E013 75.8299427 0.0032621117 1.245753e-02 3.463570e-02 9 129858467 129858598 132 + 1.902 1.794 -0.362
ENSG00000136878 E014 70.9559034 0.0018561852 2.026983e-01 3.295933e-01 9 129860937 129861033 97 + 1.831 1.787 -0.150
ENSG00000136878 E015 69.7206886 0.0033723417 2.073024e-02 5.301908e-02 9 129861543 129861612 70 + 1.865 1.762 -0.346
ENSG00000136878 E016 96.2008054 0.0009608095 3.117917e-03 1.061286e-02 9 129863186 129863299 114 + 1.999 1.897 -0.341
ENSG00000136878 E017 93.2451870 0.0004138210 4.710179e-03 1.512461e-02 9 129865303 129865381 79 + 1.981 1.887 -0.316
ENSG00000136878 E018 117.9402269 0.0005583678 5.895020e-04 2.495015e-03 9 129868005 129868191 187 + 2.087 1.982 -0.352
ENSG00000136878 E019 65.7256451 0.0065938398 4.912797e-01 6.285725e-01 9 129868192 129868321 130 + 1.777 1.756 -0.071
ENSG00000136878 E020 34.9330904 0.0081970716 7.923623e-01 8.672556e-01 9 129868322 129868325 4 + 1.462 1.503 0.143
ENSG00000136878 E021 54.3998063 0.0092601789 8.487995e-01 9.061288e-01 9 129868326 129868366 41 + 1.671 1.683 0.041
ENSG00000136878 E022 76.0564304 0.0050084321 4.727990e-01 6.118360e-01 9 129868367 129868449 83 + 1.835 1.819 -0.053
ENSG00000136878 E023 44.9040857 0.0008708132 4.112271e-01 5.548131e-01 9 129868862 129868873 12 + 1.617 1.587 -0.101
ENSG00000136878 E024 90.0090777 0.0005687871 5.414043e-01 6.723968e-01 9 129868874 129869002 129 + 1.899 1.892 -0.023
ENSG00000136878 E025 93.3828070 0.0044204982 8.734047e-01 9.226423e-01 9 129869310 129869425 116 + 1.902 1.915 0.046
ENSG00000136878 E026 116.7691170 0.0092281444 9.472242e-01 9.708479e-01 9 129869672 129869844 173 + 2.000 2.016 0.054
ENSG00000136878 E027 24.7613373 0.0008711093 2.604918e-03 9.079089e-03 9 129869845 129870152 308 + 1.490 1.290 -0.694
ENSG00000136878 E028 93.8184856 0.0022005114 2.692387e-01 4.077360e-01 9 129870453 129870547 95 + 1.862 1.933 0.239
ENSG00000136878 E029 65.5267151 0.0004041563 3.307512e-01 4.743290e-01 9 129873482 129873515 34 + 1.711 1.777 0.225
ENSG00000136878 E030 77.4848027 0.0003444787 5.920606e-01 7.146917e-01 9 129873699 129873744 46 + 1.838 1.832 -0.019
ENSG00000136878 E031 99.9404344 0.0017353195 6.350675e-01 7.494325e-01 9 129874576 129874659 84 + 1.941 1.941 -0.001
ENSG00000136878 E032 103.8003092 0.0009285043 7.918054e-01 8.668384e-01 9 129874660 129874756 97 + 1.951 1.959 0.029
ENSG00000136878 E033 100.0154918 0.0004027582 1.846372e-01 3.070276e-01 9 129874829 129874955 127 + 1.965 1.932 -0.112
ENSG00000136878 E034 133.9893633 0.0036061549 4.202555e-01 5.634627e-01 9 129875310 129875479 170 + 2.080 2.067 -0.045
ENSG00000136878 E035 94.7043216 0.0003241609 5.541060e-01 6.831262e-01 9 129875560 129875596 37 + 1.926 1.920 -0.018
ENSG00000136878 E036 102.7628396 0.0003312142 6.523433e-01 7.630556e-01 9 129875597 129875641 45 + 1.955 1.956 0.003
ENSG00000136878 E037 141.0775333 0.0002705213 9.404810e-01 9.666297e-01 9 129876130 129876238 109 + 2.080 2.096 0.054
ENSG00000136878 E038 148.6670067 0.0002731275 5.209984e-01 6.549023e-01 9 129878338 129878440 103 + 2.083 2.123 0.133
ENSG00000136878 E039 1.6250712 0.1769380749 6.813083e-01 7.850224e-01 9 129879373 129879572 200 + 0.300 0.425 0.735
ENSG00000136878 E040 131.3604729 0.0002528776 1.032630e-01 1.954411e-01 9 129879573 129879644 72 + 2.003 2.079 0.255
ENSG00000136878 E041 175.9423790 0.0002374750 2.993877e-02 7.183843e-02 9 129880113 129880289 177 + 2.121 2.206 0.286
ENSG00000136878 E042 30.2255849 0.0074255879 1.835956e-01 3.057205e-01 9 129880290 129880378 89 + 1.341 1.471 0.450
ENSG00000136878 E043 50.5312530 0.0004490258 6.109989e-02 1.284840e-01 9 129880379 129880466 88 + 1.555 1.681 0.428
ENSG00000136878 E044 691.6583417 0.0031833771 8.766059e-11 1.562894e-09 9 129880467 129881828 1362 + 2.623 2.828 0.682