ENSG00000136877

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373247 ENSG00000136877 HEK293_OSMI2_2hA HEK293_TMG_2hB FPGS protein_coding protein_coding 81.08989 144.2156 47.32333 6.764302 1.733941 -1.607399 37.606436 70.825363 19.576277 7.584302 1.0237403 -1.8546266 0.4316417 0.49520000 0.41430000 -0.0809 0.63761044 3.350887e-06 FALSE TRUE
ENST00000475270 ENSG00000136877 HEK293_OSMI2_2hA HEK293_TMG_2hB FPGS protein_coding processed_transcript 81.08989 144.2156 47.32333 6.764302 1.733941 -1.607399 11.098244 28.151299 2.202345 9.269094 1.1208653 -3.6700659 0.1205042 0.19236667 0.04526667 -0.1471 0.43569483 3.350887e-06 FALSE FALSE
ENST00000475765 ENSG00000136877 HEK293_OSMI2_2hA HEK293_TMG_2hB FPGS protein_coding processed_transcript 81.08989 144.2156 47.32333 6.764302 1.733941 -1.607399 7.716967 8.833043 7.320585 2.184492 0.7486516 -0.2706146 0.1178625 0.06013333 0.15623333 0.0961 0.01665311 3.350887e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136877 E001 18.4500910 0.0009710744 1.819710e-05 1.139632e-04 9 127794597 127794681 85 + 1.444 1.099 -1.213
ENSG00000136877 E002 22.0796502 0.0008496145 5.893749e-05 3.262104e-04 9 127794682 127794812 131 + 1.488 1.188 -1.047
ENSG00000136877 E003 1.6554768 0.0086714757 5.927536e-02 1.253969e-01 9 127802858 127802878 21 + 0.600 0.276 -1.743
ENSG00000136877 E004 3.0916839 0.0699992655 7.414412e-02 1.501709e-01 9 127802879 127802881 3 + 0.761 0.448 -1.403
ENSG00000136877 E005 7.7852472 0.0672059084 5.250420e-03 1.661283e-02 9 127802882 127802892 11 + 1.149 0.729 -1.585
ENSG00000136877 E006 34.8301356 0.0355657553 5.965642e-03 1.851633e-02 9 127802893 127802910 18 + 1.654 1.386 -0.920
ENSG00000136877 E007 45.1226881 0.0501343679 7.900766e-03 2.352872e-02 9 127802911 127802916 6 + 1.774 1.491 -0.962
ENSG00000136877 E008 49.7865551 0.0536568476 4.956603e-03 1.581060e-02 9 127802917 127802917 1 + 1.835 1.524 -1.057
ENSG00000136877 E009 82.6304512 0.0517111182 1.800242e-02 4.713766e-02 9 127802918 127802931 14 + 2.000 1.765 -0.791
ENSG00000136877 E010 219.8218387 0.0150434680 5.159081e-02 1.119800e-01 9 127802932 127803023 92 + 2.323 2.222 -0.336
ENSG00000136877 E011 246.7185858 0.0075029936 8.380379e-02 1.655065e-01 9 127803024 127803062 39 + 2.346 2.280 -0.220
ENSG00000136877 E012 3.3665639 0.0240083442 1.444547e-04 7.229300e-04 9 127803063 127803156 94 + 0.942 0.353 -2.627
ENSG00000136877 E013 4.9068669 0.0282065836 4.818209e-02 1.059579e-01 9 127803208 127803251 44 + 0.911 0.622 -1.165
ENSG00000136877 E014 16.1365265 0.0076271583 1.342547e-01 2.400707e-01 9 127803252 127803323 72 + 1.247 1.111 -0.485
ENSG00000136877 E015 21.7242236 0.0008921518 2.296160e-01 3.619787e-01 9 127803324 127803404 81 + 1.327 1.240 -0.307
ENSG00000136877 E016 201.9965025 0.0072331310 3.218273e-01 4.650851e-01 9 127804285 127804285 1 + 2.233 2.201 -0.108
ENSG00000136877 E017 583.3413265 0.0008506783 2.306440e-01 3.632275e-01 9 127804286 127804413 128 + 2.671 2.663 -0.027
ENSG00000136877 E018 561.3815677 0.0001194807 9.114782e-01 9.477998e-01 9 127804499 127804552 54 + 2.632 2.650 0.060
ENSG00000136877 E019 623.0610594 0.0001100488 8.498723e-01 9.068346e-01 9 127804636 127804700 65 + 2.683 2.695 0.042
ENSG00000136877 E020 13.1330919 0.0015811678 3.841081e-04 1.713279e-03 9 127804701 127804857 157 + 1.302 0.971 -1.189
ENSG00000136877 E021 28.8429528 0.0015896470 1.961333e-16 8.125271e-15 9 127806497 127806972 476 + 1.742 1.203 -1.857
ENSG00000136877 E022 388.8571785 0.0001773602 7.780953e-01 8.572262e-01 9 127806973 127806991 19 + 2.471 2.493 0.074
ENSG00000136877 E023 763.0768832 0.0001086886 8.959601e-01 9.375091e-01 9 127806992 127807087 96 + 2.766 2.784 0.060
ENSG00000136877 E024 633.0004320 0.0001218615 6.231479e-03 1.922257e-02 9 127807209 127807286 78 + 2.723 2.692 -0.103
ENSG00000136877 E025 577.5893246 0.0001167092 2.357244e-04 1.115540e-03 9 127807421 127807482 62 + 2.700 2.650 -0.164
ENSG00000136877 E026 601.1639031 0.0001175820 1.498924e-03 5.632249e-03 9 127807586 127807672 87 + 2.709 2.670 -0.131
ENSG00000136877 E027 380.6176540 0.0001912631 3.491524e-02 8.149255e-02 9 127807673 127807688 16 + 2.505 2.474 -0.104
ENSG00000136877 E028 30.8603556 0.0164147323 8.482506e-07 7.155514e-06 9 127807689 127807775 87 + 1.702 1.287 -1.428
ENSG00000136877 E029 11.4379258 0.0063743699 1.165875e-05 7.629676e-05 9 127807776 127807849 74 + 1.315 0.870 -1.617
ENSG00000136877 E030 17.9767315 0.0015252197 2.953132e-03 1.012506e-02 9 127808147 127808233 87 + 1.373 1.128 -0.863
ENSG00000136877 E031 408.5798756 0.0014727531 7.466019e-01 8.343073e-01 9 127808234 127808263 30 + 2.506 2.515 0.029
ENSG00000136877 E032 512.6938487 0.0014508408 4.051889e-01 5.488711e-01 9 127808264 127808311 48 + 2.579 2.619 0.132
ENSG00000136877 E033 656.9188065 0.0001172095 5.316030e-05 2.975642e-04 9 127808558 127808705 148 + 2.643 2.731 0.293
ENSG00000136877 E034 10.6156419 0.0018749468 1.904819e-04 9.232687e-04 9 127808722 127808799 78 + 1.247 0.869 -1.381
ENSG00000136877 E035 357.1858820 0.0021503370 1.856300e-03 6.777360e-03 9 127808800 127808889 90 + 2.351 2.473 0.408
ENSG00000136877 E036 251.9644690 0.0073133909 8.060124e-01 8.766894e-01 9 127809684 127809834 151 + 2.273 2.309 0.118
ENSG00000136877 E037 0.8126288 0.1811175214 3.944425e-01 5.382744e-01 9 127809994 127810030 37 + 0.001 0.238 9.081
ENSG00000136877 E038 72.8257554 0.0067245821 1.977946e-01 3.234744e-01 9 127810031 127810106 76 + 1.811 1.751 -0.205
ENSG00000136877 E039 138.6688659 0.0002310842 1.174463e-01 2.163099e-01 9 127810945 127811011 67 + 1.981 2.056 0.253
ENSG00000136877 E040 407.3219455 0.0024469451 1.026826e-03 4.051338e-03 9 127813195 127813323 129 + 2.407 2.534 0.424
ENSG00000136877 E041 1779.2058358 0.0050786517 2.642296e-06 2.002300e-05 9 127813324 127814081 758 + 3.009 3.181 0.574
ENSG00000136877 E042 30.8132940 0.0006509810 8.645649e-01 9.167033e-01 9 127814208 127814438 231 + 1.405 1.407 0.008