ENSG00000136870

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259395 ENSG00000136870 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF189 protein_coding protein_coding 6.426145 2.537708 10.15094 0.1184179 0.4407109 1.995761 1.0816104 0.2368393 1.6886941 0.07448157 0.48456792 2.7827819 0.15235833 0.0913000 0.16420000 0.07290000 5.687501e-01 1.232225e-06 FALSE TRUE
ENST00000339664 ENSG00000136870 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF189 protein_coding protein_coding 6.426145 2.537708 10.15094 0.1184179 0.4407109 1.995761 0.8301968 0.0000000 1.6575877 0.00000000 0.31628106 7.3816188 0.11299583 0.0000000 0.16460000 0.16460000 1.232225e-06 1.232225e-06 FALSE TRUE
ENST00000374861 ENSG00000136870 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF189 protein_coding protein_coding 6.426145 2.537708 10.15094 0.1184179 0.4407109 1.995761 2.6686075 0.6702136 5.2105336 0.37471624 0.15399389 2.9401374 0.39647083 0.2790333 0.51416667 0.23513333 5.953235e-01 1.232225e-06 FALSE TRUE
ENST00000615466 ENSG00000136870 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF189 protein_coding protein_coding 6.426145 2.537708 10.15094 0.1184179 0.4407109 1.995761 0.3262933 0.3988833 0.3660204 0.25819071 0.04743455 -0.1208780 0.07316667 0.1676000 0.03580000 -0.13180000 7.196046e-01 1.232225e-06 FALSE TRUE
MSTRG.33167.3 ENSG00000136870 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF189 protein_coding   6.426145 2.537708 10.15094 0.1184179 0.4407109 1.995761 0.6031587 1.2317718 0.6399246 0.67920141 0.17382500 -0.9340557 0.11578333 0.4620333 0.06310000 -0.39893333 4.811742e-01 1.232225e-06 FALSE TRUE
MSTRG.33167.4 ENSG00000136870 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF189 protein_coding   6.426145 2.537708 10.15094 0.1184179 0.4407109 1.995761 0.5280917 0.0000000 0.4734897 0.00000000 0.10728425 5.5954131 0.07069167 0.0000000 0.04743333 0.04743333 6.212655e-03 1.232225e-06 FALSE TRUE
MSTRG.33167.5 ENSG00000136870 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF189 protein_coding   6.426145 2.537708 10.15094 0.1184179 0.4407109 1.995761 0.3881869 0.0000000 0.1146851 0.00000000 0.11468510 3.6402172 0.07852083 0.0000000 0.01066667 0.01066667 1.000000e+00 1.232225e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136870 E001 0.7300161 0.0565387586 2.931328e-01 4.341715e-01 9 101398851 101398872 22 + 0.221 0.000 -12.816
ENSG00000136870 E002 1.4579559 0.3325578916 1.751233e-01 2.948427e-01 9 101398873 101398959 87 + 0.365 0.000 -13.805
ENSG00000136870 E003 11.6790335 0.0015680905 6.678881e-01 7.750320e-01 9 101398960 101399027 68 + 0.959 1.085 0.460
ENSG00000136870 E004 18.9381693 0.0010504851 2.131564e-01 3.422654e-01 9 101399028 101399088 61 + 1.167 1.229 0.219
ENSG00000136870 E005 24.6179036 0.0021061832 1.291862e-02 3.572265e-02 9 101399089 101399189 101 + 1.293 1.249 -0.153
ENSG00000136870 E006 6.6610673 0.0027415720 4.224274e-01 5.655661e-01 9 101399395 101399466 72 + 0.772 0.818 0.180
ENSG00000136870 E007 6.1911825 0.0028807014 6.150285e-02 1.291672e-01 9 101399467 101399530 64 + 0.772 0.622 -0.627
ENSG00000136870 E008 5.4856555 0.0050246400 1.260452e-03 4.844965e-03 9 101399884 101399925 42 + 0.762 0.254 -2.586
ENSG00000136870 E009 16.4595432 0.0011465491 3.890279e-04 1.732247e-03 9 101399926 101399928 3 + 1.155 0.912 -0.891
ENSG00000136870 E010 34.5712073 0.0006197108 2.525656e-07 2.373992e-06 9 101399929 101400010 82 + 1.459 1.208 -0.876
ENSG00000136870 E011 2.5788360 0.0092458685 6.066357e-03 1.878448e-02 9 101407412 101407532 121 + 0.286 0.868 2.778
ENSG00000136870 E012 438.4753408 0.0362058899 2.095075e-03 7.518576e-03 9 101407929 101410660 2732 + 2.463 2.715 0.838