ENSG00000136861

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349780 ENSG00000136861 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK5RAP2 protein_coding protein_coding 20.40763 18.93163 20.14692 0.961804 0.1316913 0.08971431 4.0290402 0.9484423 7.022445 0.9484423 0.7580887 2.8752629 0.20220833 0.05206667 0.3486667 0.29660000 5.796487e-02 2.582331e-18 FALSE TRUE
ENST00000360190 ENSG00000136861 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK5RAP2 protein_coding protein_coding 20.40763 18.93163 20.14692 0.961804 0.1316913 0.08971431 4.4720110 3.3087240 4.291028 0.6705214 0.7241462 0.3740530 0.21585417 0.17473333 0.2131667 0.03843333 7.723626e-01 2.582331e-18 FALSE TRUE
ENST00000425647 ENSG00000136861 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK5RAP2 protein_coding protein_coding 20.40763 18.93163 20.14692 0.961804 0.1316913 0.08971431 2.3527884 2.9493157 1.560477 0.5216440 0.4006035 -0.9140611 0.11115417 0.15500000 0.0776000 -0.07740000 1.542777e-01 2.582331e-18 FALSE TRUE
ENST00000479584 ENSG00000136861 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK5RAP2 protein_coding processed_transcript 20.40763 18.93163 20.14692 0.961804 0.1316913 0.08971431 0.8221662 1.7653995 0.000000 0.2970249 0.0000000 -7.4719999 0.03869583 0.09393333 0.0000000 -0.09393333 1.638094e-16 2.582331e-18 FALSE TRUE
ENST00000691551 ENSG00000136861 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK5RAP2 protein_coding nonsense_mediated_decay 20.40763 18.93163 20.14692 0.961804 0.1316913 0.08971431 3.1262295 6.8134430 0.000000 1.6511339 0.0000000 -9.4143561 0.15161667 0.35500000 0.0000000 -0.35500000 2.582331e-18 2.582331e-18 FALSE TRUE
MSTRG.33306.21 ENSG00000136861 HEK293_OSMI2_2hA HEK293_TMG_2hB CDK5RAP2 protein_coding   20.40763 18.93163 20.14692 0.961804 0.1316913 0.08971431 1.4901511 1.6064296 2.841524 0.6458933 0.3906036 0.8189223 0.07441667 0.08746667 0.1410333 0.05356667 5.055990e-01 2.582331e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136861 E001 0.9889485 0.0297713104 5.717873e-02 1.217705e-01 9 120388875 120388875 1 - 0.112 0.446 2.604
ENSG00000136861 E002 1.1404639 0.0178061324 1.606323e-01 2.759547e-01 9 120388876 120388880 5 - 0.201 0.446 1.605
ENSG00000136861 E003 1.1404639 0.0178061324 1.606323e-01 2.759547e-01 9 120388881 120388886 6 - 0.201 0.446 1.605
ENSG00000136861 E004 1.1404639 0.0178061324 1.606323e-01 2.759547e-01 9 120388887 120388889 3 - 0.201 0.446 1.605
ENSG00000136861 E005 1.1404639 0.0178061324 1.606323e-01 2.759547e-01 9 120388890 120388890 1 - 0.201 0.446 1.605
ENSG00000136861 E006 2.4616742 0.0062883235 1.024446e-02 2.936663e-02 9 120388891 120388901 11 - 0.275 0.695 2.161
ENSG00000136861 E007 2.4616742 0.0062883235 1.024446e-02 2.936663e-02 9 120388902 120388903 2 - 0.275 0.695 2.161
ENSG00000136861 E008 5.6410567 0.0029703140 1.266413e-03 4.865012e-03 9 120388904 120388912 9 - 0.563 0.983 1.700
ENSG00000136861 E009 9.6746869 0.0054448623 9.948902e-04 3.940519e-03 9 120388913 120388918 6 - 0.820 1.176 1.321
ENSG00000136861 E010 149.1438142 0.0026384459 3.422174e-20 2.230973e-18 9 120388919 120389194 276 - 1.971 2.319 1.165
ENSG00000136861 E011 71.1405006 0.0082168164 4.400785e-06 3.172071e-05 9 120389195 120389195 1 - 1.701 1.976 0.928
ENSG00000136861 E012 73.8757582 0.0076742940 7.896767e-07 6.705563e-06 9 120389196 120389197 2 - 1.708 1.998 0.975
ENSG00000136861 E013 73.9488361 0.0066599603 2.594055e-07 2.431287e-06 9 120389198 120389198 1 - 1.709 1.999 0.980
ENSG00000136861 E014 74.0177217 0.0062167926 1.511178e-07 1.482596e-06 9 120389199 120389200 2 - 1.708 2.000 0.981
ENSG00000136861 E015 98.2966037 0.0043418116 4.554870e-14 1.358472e-12 9 120389201 120389235 35 - 1.784 2.145 1.211
ENSG00000136861 E016 76.3651039 0.0034983920 2.220417e-11 4.372221e-10 9 120389236 120389241 6 - 1.701 2.028 1.102
ENSG00000136861 E017 107.4656363 0.0013537869 2.536725e-19 1.501796e-17 9 120389242 120389287 46 - 1.838 2.178 1.143
ENSG00000136861 E018 73.9958951 0.0003811461 7.725221e-16 2.960793e-14 9 120389288 120389292 5 - 1.683 2.014 1.118
ENSG00000136861 E019 6.6358665 0.0274368078 6.195744e-01 7.369563e-01 9 120389293 120389740 448 - 0.923 0.849 -0.282
ENSG00000136861 E020 114.5709384 0.0034392843 1.544766e-15 5.695822e-14 9 120389741 120389787 47 - 1.861 2.206 1.158
ENSG00000136861 E021 62.6858953 0.0004093801 7.416494e-06 5.074885e-05 9 120389788 120394511 4724 - 1.701 1.893 0.649
ENSG00000136861 E022 167.3546456 0.0014022057 6.316056e-24 6.225587e-22 9 120394512 120394638 127 - 2.037 2.362 1.086
ENSG00000136861 E023 6.7119486 0.1243754228 5.397513e-01 6.709905e-01 9 120394639 120397513 2875 - 0.840 0.939 0.378
ENSG00000136861 E024 191.5553476 0.0002059257 2.145301e-25 2.433658e-23 9 120400742 120400885 144 - 2.134 2.399 0.884
ENSG00000136861 E025 0.6266857 0.0172671820 8.317681e-01 8.945759e-01 9 120400886 120401019 134 - 0.201 0.235 0.284
ENSG00000136861 E026 283.8624445 0.0034738166 1.270274e-09 1.846464e-08 9 120402806 120403071 266 - 2.342 2.547 0.685
ENSG00000136861 E027 4.2039098 0.0037523493 5.874939e-01 7.107666e-01 9 120403072 120403242 171 - 0.684 0.753 0.285
ENSG00000136861 E028 2.3175482 0.0081104308 1.464683e-01 2.568824e-01 9 120403243 120403315 73 - 0.393 0.627 1.133
ENSG00000136861 E029 7.7488818 0.0021627676 6.510522e-01 7.620064e-01 9 120403316 120404035 720 - 0.923 0.967 0.165
ENSG00000136861 E030 136.7510112 0.0114278012 3.839137e-03 1.268974e-02 9 120404036 120404113 78 - 2.047 2.219 0.576
ENSG00000136861 E031 16.5021374 0.0022569748 6.918609e-03 2.101406e-02 9 120404114 120406145 2032 - 1.341 1.097 -0.863
ENSG00000136861 E032 5.6078437 0.0028406371 8.920334e-02 1.739166e-01 9 120406146 120407011 866 - 0.923 0.695 -0.899
ENSG00000136861 E033 82.1257499 0.0174826351 4.411543e-03 1.429641e-02 9 120407012 120407087 76 - 1.801 2.020 0.736
ENSG00000136861 E034 95.0583603 0.0036865643 4.782836e-08 5.183011e-07 9 120407088 120407233 146 - 1.845 2.093 0.834
ENSG00000136861 E035 48.5794007 0.0007079035 2.335990e-03 8.262626e-03 9 120407234 120407246 13 - 1.620 1.767 0.498
ENSG00000136861 E036 41.2331063 0.0020725175 1.040375e-02 2.975573e-02 9 120407247 120407248 2 - 1.554 1.694 0.477
ENSG00000136861 E037 8.3079822 0.0233178174 2.785870e-02 6.773811e-02 9 120407249 120408346 1098 - 1.087 0.783 -1.146
ENSG00000136861 E038 155.7072498 0.0002602485 5.069666e-11 9.411397e-10 9 120408347 120408468 122 - 2.097 2.279 0.606
ENSG00000136861 E039 186.6852295 0.0002490103 4.960916e-09 6.479804e-08 9 120409127 120409316 190 - 2.197 2.343 0.487
ENSG00000136861 E040 125.8255859 0.0002370172 6.502395e-04 2.716924e-03 9 120411358 120411474 117 - 2.053 2.153 0.333
ENSG00000136861 E041 0.8964071 0.2035573046 3.876990e-02 8.876048e-02 9 120411680 120412366 687 - 0.443 0.000 -13.489
ENSG00000136861 E042 155.6351810 0.0014287048 4.676342e-02 1.034022e-01 9 120415040 120415159 120 - 2.168 2.226 0.194
ENSG00000136861 E043 164.3740013 0.0017613122 4.144254e-01 5.578409e-01 9 120419788 120419901 114 - 2.237 2.201 -0.120
ENSG00000136861 E044 116.0393499 0.0002575524 8.210266e-01 8.871749e-01 9 120419902 120419960 59 - 2.078 2.063 -0.052
ENSG00000136861 E045 102.0161731 0.0002884306 9.801557e-01 9.916135e-01 9 120422693 120422741 49 - 2.019 2.010 -0.031
ENSG00000136861 E046 0.0000000       9 120437281 120437294 14 -      
ENSG00000136861 E047 189.1078456 0.0001989444 3.836178e-01 5.278155e-01 9 120437295 120437527 233 - 2.272 2.286 0.047
ENSG00000136861 E048 136.1724597 0.0028170619 9.598341e-01 9.787428e-01 9 120439399 120439517 119 - 2.141 2.134 -0.024
ENSG00000136861 E049 301.1709006 0.0028940167 2.164494e-01 3.461422e-01 9 120439518 120439972 455 - 2.504 2.456 -0.162
ENSG00000136861 E050 11.3546161 0.0164756996 4.776040e-02 1.051942e-01 9 120439973 120440297 325 - 1.189 0.952 -0.862
ENSG00000136861 E051 49.6966852 0.0196136240 5.836380e-11 1.070985e-09 9 120440298 120443619 3322 - 1.905 1.300 -2.068
ENSG00000136861 E052 117.6082465 0.0023907740 1.136787e-02 3.204442e-02 9 120443620 120443742 123 - 2.126 2.016 -0.370
ENSG00000136861 E053 108.9683555 0.0005463322 4.557464e-06 3.274788e-05 9 120447895 120448126 232 - 2.117 1.946 -0.574
ENSG00000136861 E054 188.9889812 0.0024922752 2.994232e-07 2.771391e-06 9 120453456 120453873 418 - 2.362 2.171 -0.639
ENSG00000136861 E055 113.0873972 0.0030988987 2.565332e-04 1.202450e-03 9 120458450 120458622 173 - 2.131 1.964 -0.558
ENSG00000136861 E056 80.0082503 0.0004410479 1.694181e-05 1.068007e-04 9 120460572 120460667 96 - 1.989 1.805 -0.616
ENSG00000136861 E057 0.3686942 0.0315700704 8.712587e-01 9.212053e-01 9 120460668 120460747 80 - 0.112 0.134 0.289
ENSG00000136861 E058 1.6606631 0.0082201983 2.418330e-01 3.763505e-01 9 120465798 120467429 1632 - 0.526 0.317 -1.131
ENSG00000136861 E059 91.9155739 0.0044173858 5.723765e-06 4.020280e-05 9 120467860 120467997 138 - 2.068 1.833 -0.792
ENSG00000136861 E060 55.8056929 0.0192980503 7.838549e-03 2.337683e-02 9 120470111 120470217 107 - 1.850 1.620 -0.780
ENSG00000136861 E061 17.3853494 0.0281472504 1.163495e-01 2.147428e-01 9 120470218 120470220 3 - 1.341 1.151 -0.667
ENSG00000136861 E062 84.2248092 0.0152789690 7.944133e-02 1.586457e-01 9 120471748 120471878 131 - 1.991 1.855 -0.455
ENSG00000136861 E063 1.7046834 0.0139918976 2.466755e-01 3.820497e-01 9 120475032 120475106 75 - 0.526 0.317 -1.131
ENSG00000136861 E064 1.2564799 0.0447755249 7.007526e-01 8.001608e-01 9 120475206 120475281 76 - 0.394 0.317 -0.454
ENSG00000136861 E065 0.3030308 0.3930915517 3.707137e-01   9 120475664 120475733 70 - 0.202 0.000 -11.907
ENSG00000136861 E066 82.9102199 0.0071375507 1.052295e-03 4.140446e-03 9 120477350 120477450 101 - 2.009 1.812 -0.661
ENSG00000136861 E067 101.8200280 0.0235855280 3.951580e-02 9.013593e-02 9 120487294 120487437 144 - 2.090 1.913 -0.592
ENSG00000136861 E068 0.2965864 0.1578742920 1.806988e-01   9 120490746 120491306 561 - 0.000 0.232 12.172
ENSG00000136861 E069 118.2721253 0.0176518439 8.546905e-04 3.454262e-03 9 120491307 120491477 171 - 2.182 1.934 -0.833
ENSG00000136861 E070 1.5792929 0.0451306272 1.313107e-01 2.359721e-01 9 120517684 120517756 73 - 0.526 0.236 -1.708
ENSG00000136861 E071 4.4360699 0.0037796162 6.283745e-02 1.314339e-01 9 120517757 120517886 130 - 0.857 0.588 -1.108
ENSG00000136861 E072 92.9379466 0.0055103012 2.686660e-08 3.053634e-07 9 120518427 120518523 97 - 2.097 1.798 -1.007
ENSG00000136861 E073 69.0255889 0.0006787111 1.309538e-12 3.150724e-11 9 120518524 120518599 76 - 1.978 1.648 -1.113
ENSG00000136861 E074 56.2242656 0.0004149714 7.342520e-12 1.562271e-10 9 120518600 120518645 46 - 1.895 1.550 -1.168
ENSG00000136861 E075 62.3977217 0.0004441405 3.376298e-11 6.444629e-10 9 120524986 120525078 93 - 1.929 1.612 -1.075
ENSG00000136861 E076 71.9936072 0.0003650554 5.291861e-13 1.356783e-11 9 120527806 120527905 100 - 1.994 1.672 -1.085
ENSG00000136861 E077 46.9905810 0.0004887960 1.490510e-10 2.553098e-09 9 120527906 120527925 20 - 1.820 1.468 -1.198
ENSG00000136861 E078 62.3667954 0.0007664160 4.006095e-15 1.398199e-13 9 120528744 120528773 30 - 1.951 1.563 -1.313
ENSG00000136861 E079 52.3601088 0.0050823264 1.638065e-11 3.293288e-10 9 120528774 120528797 24 - 1.890 1.458 -1.468
ENSG00000136861 E080 1.8297837 0.0517432191 6.127589e-02 1.287879e-01 9 120528893 120528904 12 - 0.596 0.235 -2.033
ENSG00000136861 E081 0.1482932 0.0413519155 3.978379e-01   9 120529304 120529422 119 - 0.000 0.133 11.193
ENSG00000136861 E082 107.3296987 0.0105807524 4.441857e-08 4.840917e-07 9 120529978 120530140 163 - 2.173 1.824 -1.171
ENSG00000136861 E083 0.1472490 0.0432005882 5.987675e-01   9 120530141 120530142 2 - 0.112 0.000 -10.900
ENSG00000136861 E084 0.0000000       9 120532467 120532555 89 -      
ENSG00000136861 E085 100.2163481 0.0133532713 1.208025e-07 1.208133e-06 9 120536372 120536526 155 - 2.150 1.781 -1.239
ENSG00000136861 E086 84.6012156 0.0101305069 8.676681e-10 1.300452e-08 9 120539041 120539164 124 - 2.088 1.682 -1.367
ENSG00000136861 E087 74.1584068 0.0240981865 1.442769e-06 1.158219e-05 9 120545714 120545790 77 - 2.039 1.603 -1.470
ENSG00000136861 E088 80.3690862 0.0084527789 2.538751e-10 4.175352e-09 9 120550792 120550902 111 - 2.064 1.662 -1.356
ENSG00000136861 E089 66.1945477 0.0003570426 3.208177e-13 8.484986e-12 9 120568321 120568388 68 - 1.964 1.626 -1.141
ENSG00000136861 E090 0.5483223 0.0211930949 4.460331e-01 5.875764e-01 9 120570714 120570899 186 - 0.112 0.235 1.288
ENSG00000136861 E091 0.3697384 0.0249320735 1.469925e-01 2.575901e-01 9 120571747 120571973 227 - 0.000 0.235 12.197
ENSG00000136861 E092 42.2487691 0.0004877670 1.907898e-11 3.794705e-10 9 120571974 120571976 3 - 1.788 1.399 -1.328
ENSG00000136861 E093 58.7869773 0.0004697911 1.821921e-14 5.776694e-13 9 120571977 120572041 65 - 1.926 1.546 -1.289
ENSG00000136861 E094 47.5729900 0.0007591230 3.771734e-12 8.420266e-11 9 120579920 120580170 251 - 1.838 1.452 -1.312