ENSG00000136854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373299 ENSG00000136854 HEK293_OSMI2_2hA HEK293_TMG_2hB STXBP1 protein_coding protein_coding 16.16002 20.0664 13.58005 0.6729082 1.089169 -0.5629499 11.9589141 14.3021844 9.256543 1.34772210 0.2813972 -0.6271408 0.735820833 0.710000000 0.69303333 -0.01696667 0.97468889 1.692862e-06 FALSE  
ENST00000476182 ENSG00000136854 HEK293_OSMI2_2hA HEK293_TMG_2hB STXBP1 protein_coding protein_coding 16.16002 20.0664 13.58005 0.6729082 1.089169 -0.5629499 0.8412018 1.5415355 0.576646 0.08066797 0.1216463 -1.4031346 0.050508333 0.076766667 0.04163333 -0.03513333 0.03620687 1.692862e-06    
ENST00000625363 ENSG00000136854 HEK293_OSMI2_2hA HEK293_TMG_2hB STXBP1 protein_coding protein_coding 16.16002 20.0664 13.58005 0.6729082 1.089169 -0.5629499 0.1068778 0.0000000 0.855022 0.00000000 0.8550220 6.4346650 0.006804167 0.000000000 0.05443333 0.05443333 0.78351499 1.692862e-06 FALSE  
ENST00000628638 ENSG00000136854 HEK293_OSMI2_2hA HEK293_TMG_2hB STXBP1 protein_coding processed_transcript 16.16002 20.0664 13.58005 0.6729082 1.089169 -0.5629499 0.1428741 1.1429927 0.000000 1.14299269 0.0000000 -6.8492396 0.007537500 0.060300000 0.00000000 -0.06030000 0.85731315 1.692862e-06 FALSE  
ENST00000637953 ENSG00000136854 HEK293_OSMI2_2hA HEK293_TMG_2hB STXBP1 protein_coding protein_coding 16.16002 20.0664 13.58005 0.6729082 1.089169 -0.5629499 0.5938812 0.1165824 1.139851 0.11658245 0.3418109 3.1832971 0.038037500 0.005833333 0.08116667 0.07533333 0.02275750 1.692862e-06 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136854 E001 0.0000000       9 127579370 127579534 165 +      
ENSG00000136854 E002 0.0000000       9 127611760 127611804 45 +      
ENSG00000136854 E003 0.0000000       9 127611805 127611833 29 +      
ENSG00000136854 E004 0.0000000       9 127611834 127611856 23 +      
ENSG00000136854 E005 0.0000000       9 127611857 127612047 191 +      
ENSG00000136854 E006 2.6195244 0.0059874647 1.607813e-02 4.290983e-02 9 127612222 127612247 26 + 0.738 0.384 -1.655
ENSG00000136854 E007 5.0436242 0.0031236659 4.242646e-02 9.549431e-02 9 127612248 127612264 17 + 0.907 0.671 -0.939
ENSG00000136854 E008 9.5608839 0.0148467309 1.103636e-02 3.124896e-02 9 127612265 127612276 12 + 1.158 0.893 -0.976
ENSG00000136854 E009 41.2625274 0.0083124377 2.877405e-02 6.955047e-02 9 127612277 127612359 83 + 1.674 1.560 -0.386
ENSG00000136854 E010 31.5691312 0.0242188838 2.349552e-01 3.682932e-01 9 127612360 127612360 1 + 1.534 1.467 -0.229
ENSG00000136854 E011 73.3475005 0.0101405317 4.245603e-02 9.554520e-02 9 127612361 127612440 80 + 1.905 1.819 -0.290
ENSG00000136854 E012 13.9441269 0.0012808948 1.145034e-03 4.454185e-03 9 127613266 127613751 486 + 0.907 1.263 1.293
ENSG00000136854 E013 0.6966155 0.0172671820 5.019194e-01 6.380701e-01 9 127639428 127639617 190 + 0.138 0.268 1.195
ENSG00000136854 E014 0.0000000       9 127642343 127642468 126 +      
ENSG00000136854 E015 1.9415663 0.0442827188 3.701258e-01 5.145572e-01 9 127642469 127642563 95 + 0.326 0.517 1.033
ENSG00000136854 E016 47.8765799 0.0047927976 9.908670e-03 2.853879e-02 9 127651603 127651604 2 + 1.740 1.622 -0.401
ENSG00000136854 E017 52.9816222 0.0060505020 3.507340e-02 8.179014e-02 9 127651605 127651623 19 + 1.769 1.679 -0.306
ENSG00000136854 E018 65.2686501 0.0004556778 4.115251e-02 9.316596e-02 9 127651624 127651652 29 + 1.840 1.785 -0.185
ENSG00000136854 E019 91.7600728 0.0030611498 3.007567e-03 1.028845e-02 9 127653715 127653796 82 + 2.008 1.912 -0.324
ENSG00000136854 E020 5.8606038 0.0030898930 4.039306e-10 6.438116e-09 9 127653891 127654941 1051 + 1.147 0.330 -3.520
ENSG00000136854 E021 1.1093195 0.0113662554 1.611155e-02 4.298508e-02 9 127654942 127654964 23 + 0.510 0.109 -2.975
ENSG00000136854 E022 98.6704693 0.0027596988 5.904403e-03 1.835860e-02 9 127658375 127658451 77 + 2.030 1.949 -0.274
ENSG00000136854 E023 113.2253006 0.0002830405 8.194283e-03 2.427684e-02 9 127660030 127660108 79 + 2.075 2.021 -0.178
ENSG00000136854 E024 89.6758537 0.0003770839 5.015588e-03 1.597358e-02 9 127661102 127661132 31 + 1.986 1.915 -0.236
ENSG00000136854 E025 110.7008270 0.0002920670 4.604756e-02 1.021268e-01 9 127661133 127661205 73 + 2.054 2.021 -0.108
ENSG00000136854 E026 0.4031496 0.0244557581 3.114775e-01 4.539358e-01 9 127661459 127661723 265 + 0.000 0.196 18.734
ENSG00000136854 E027 135.2408244 0.0002707934 2.728427e-01 4.118007e-01 9 127663205 127663353 149 + 2.117 2.119 0.005
ENSG00000136854 E028 8.0347772 0.0032709533 4.565364e-02 1.013968e-01 9 127663354 127663722 369 + 0.767 1.039 1.036
ENSG00000136854 E029 84.0071265 0.0022409213 5.614286e-01 6.892457e-01 9 127665247 127665331 85 + 1.905 1.916 0.036
ENSG00000136854 E030 93.2418710 0.0014107439 4.433113e-03 1.435256e-02 9 127666166 127666296 131 + 2.007 1.929 -0.262
ENSG00000136854 E031 100.2371947 0.0039839236 1.139192e-02 3.210056e-02 9 127668080 127668187 108 + 2.041 1.962 -0.264
ENSG00000136854 E032 76.9459698 0.0004456482 8.438198e-02 1.664198e-01 9 127669898 127669958 61 + 1.901 1.866 -0.118
ENSG00000136854 E033 88.0913442 0.0003933710 1.023316e-01 1.940737e-01 9 127672051 127672116 66 + 1.953 1.926 -0.091
ENSG00000136854 E034 102.8217310 0.0041072054 1.369332e-01 2.438095e-01 9 127673181 127673261 81 + 2.024 1.993 -0.106
ENSG00000136854 E035 0.1472490 0.0433263777 3.503865e-01   9 127673348 127673427 80 + 0.138 0.000 -18.788
ENSG00000136854 E036 135.0165406 0.0002898127 9.445559e-01 9.691961e-01 9 127675804 127675942 139 + 2.096 2.134 0.126
ENSG00000136854 E037 138.9735540 0.0005462453 1.756043e-01 2.954714e-01 9 127676644 127676753 110 + 2.079 2.158 0.266
ENSG00000136854 E038 124.1084770 0.0002489425 2.715174e-01 4.102941e-01 9 127678431 127678523 93 + 2.036 2.108 0.239
ENSG00000136854 E039 69.6001709 0.0003536366 4.978623e-01 6.343982e-01 9 127678524 127678532 9 + 1.793 1.858 0.218
ENSG00000136854 E040 0.0000000       9 127679785 127679837 53 +      
ENSG00000136854 E041 108.2905600 0.0006054072 3.061110e-01 4.482702e-01 9 127680157 127680242 86 + 1.976 2.048 0.244
ENSG00000136854 E042 117.1273428 0.0012732292 5.084088e-02 1.106724e-01 9 127682406 127682560 155 + 1.989 2.097 0.363
ENSG00000136854 E043 0.5922303 0.0179827131 1.760867e-01 2.961226e-01 9 127683918 127683970 53 + 0.326 0.109 -1.978
ENSG00000136854 E044 3.1699335 0.0316270368 6.144600e-01 7.329321e-01 9 127684368 127684493 126 + 0.639 0.586 -0.236
ENSG00000136854 E045 1.3190478 0.0127395972 8.335475e-01 8.957269e-01 9 127684494 127684680 187 + 0.326 0.384 0.346
ENSG00000136854 E046 2.8637837 0.0055623083 2.297917e-01 3.622039e-01 9 127686458 127686537 80 + 0.675 0.515 -0.713
ENSG00000136854 E047 4.6715994 0.0035299335 1.259825e-02 3.496536e-02 9 127690134 127690774 641 + 0.457 0.860 1.746
ENSG00000136854 E048 809.6632585 0.0071543568 4.017630e-06 2.921011e-05 9 127690775 127692936 2162 + 2.768 2.963 0.647
ENSG00000136854 E049 4.7073195 0.0486872939 7.461538e-01 8.339967e-01 9 127694994 127695231 238 + 0.767 0.743 -0.097
ENSG00000136854 E050 3.3494613 0.0057133002 8.816058e-01 9.281263e-01 9 127695232 127695378 147 + 0.639 0.644 0.022
ENSG00000136854 E051 8.3516249 0.0288038141 1.201891e-01 2.202673e-01 9 127695379 127696027 649 + 0.794 1.039 0.928