ENSG00000136848

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000408936 ENSG00000136848 HEK293_OSMI2_2hA HEK293_TMG_2hB DAB2IP protein_coding protein_coding 8.11276 11.36481 7.024924 0.8333369 0.1379927 -0.6932356 4.1130365 5.9396032 3.6814012 0.90335811 0.1225632 -0.6886249 0.49389583 0.51663333 0.52463333 0.00800000 0.985703083 0.001534816 FALSE  
MSTRG.33320.12 ENSG00000136848 HEK293_OSMI2_2hA HEK293_TMG_2hB DAB2IP protein_coding   8.11276 11.36481 7.024924 0.8333369 0.1379927 -0.6932356 0.3938391 0.1901683 0.6047564 0.11111011 0.3611690 1.6188013 0.05582083 0.01833333 0.08816667 0.06983333 0.732258977 0.001534816 FALSE  
MSTRG.33320.13 ENSG00000136848 HEK293_OSMI2_2hA HEK293_TMG_2hB DAB2IP protein_coding   8.11276 11.36481 7.024924 0.8333369 0.1379927 -0.6932356 2.4437577 4.6722233 1.0597089 0.29862203 0.5575957 -2.1299755 0.29337083 0.41566667 0.14910000 -0.26656667 0.417706567 0.001534816 FALSE  
MSTRG.33320.6 ENSG00000136848 HEK293_OSMI2_2hA HEK293_TMG_2hB DAB2IP protein_coding   8.11276 11.36481 7.024924 0.8333369 0.1379927 -0.6932356 0.4390529 0.1483182 0.6533987 0.04755152 0.1902919 2.0670494 0.05798333 0.01256667 0.09386667 0.08130000 0.001534816 0.001534816 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136848 E001 0.0000000       9 121567057 121567101 45 +      
ENSG00000136848 E002 0.0000000       9 121567102 121567228 127 +      
ENSG00000136848 E003 1.7273811 0.0082526386 2.302908e-01 3.628100e-01 9 121598268 121598354 87 + 0.249 0.504 1.506
ENSG00000136848 E004 2.3916176 0.0807708277 4.957038e-01 6.324726e-01 9 121598355 121598626 272 + 0.406 0.574 0.830
ENSG00000136848 E005 1.9092905 0.0201878175 5.122721e-02 1.113362e-01 9 121599550 121599724 175 + 0.612 0.322 -1.493
ENSG00000136848 E006 1.2041422 0.1002722086 9.900176e-03 2.851631e-02 9 121599725 121599766 42 + 0.568 0.105 -3.296
ENSG00000136848 E007 3.0530548 0.0120738407 2.542961e-05 1.539207e-04 9 121651594 121651684 91 + 0.879 0.261 -2.996
ENSG00000136848 E008 7.9181940 0.0031615560 4.156888e-05 2.386466e-04 9 121651685 121651815 131 + 1.138 0.732 -1.537
ENSG00000136848 E009 9.2414805 0.0051533538 8.732347e-04 3.520572e-03 9 121651816 121651899 84 + 1.150 0.848 -1.118
ENSG00000136848 E010 18.6493113 0.0222399153 3.986526e-04 1.769157e-03 9 121678678 121678781 104 + 1.429 1.134 -1.038
ENSG00000136848 E011 3.5376712 0.0047551195 1.804810e-01 3.017846e-01 9 121678782 121678851 70 + 0.720 0.573 -0.630
ENSG00000136848 E012 2.1693306 0.0080222024 2.476794e-01 3.832128e-01 9 121678852 121678861 10 + 0.569 0.423 -0.715
ENSG00000136848 E013 2.7960163 0.0057353777 2.108401e-01 3.395448e-01 9 121678862 121678917 56 + 0.651 0.504 -0.664
ENSG00000136848 E014 32.4337925 0.0006473706 1.082714e-04 5.601379e-04 9 121699325 121699458 134 + 1.602 1.432 -0.582
ENSG00000136848 E015 2.2831946 0.0072556725 1.478835e-01 2.588043e-01 9 121737151 121737715 565 + 0.612 0.423 -0.909
ENSG00000136848 E016 0.3666179 0.0287991982 7.161988e-01 8.119111e-01 9 121742785 121742921 137 + 0.142 0.105 -0.491
ENSG00000136848 E017 0.0000000       9 121743561 121743714 154 +      
ENSG00000136848 E018 0.1817044 0.0395514377 7.673519e-01   9 121750972 121751394 423 + 0.000 0.105 14.648
ENSG00000136848 E019 0.2214452 0.0377913177 7.667281e-01   9 121751713 121751982 270 + 0.000 0.105 14.654
ENSG00000136848 E020 0.0000000       9 121752898 121753096 199 +      
ENSG00000136848 E021 46.1948929 0.0005090444 2.354142e-05 1.436206e-04 9 121757013 121757166 154 + 1.741 1.590 -0.514
ENSG00000136848 E022 46.5481816 0.0067397275 5.203046e-04 2.235759e-03 9 121758898 121758996 99 + 1.741 1.592 -0.508
ENSG00000136848 E023 137.4907579 0.0002485434 9.023505e-08 9.234919e-07 9 121759885 121760339 455 + 2.176 2.084 -0.311
ENSG00000136848 E024 69.1481468 0.0004124632 8.651865e-04 3.491543e-03 9 121760340 121760439 100 + 1.874 1.799 -0.251
ENSG00000136848 E025 79.7312819 0.0017117159 3.619649e-04 1.626575e-03 9 121763505 121763649 145 + 1.938 1.852 -0.289
ENSG00000136848 E026 64.4517930 0.0022619976 2.112223e-02 5.385584e-02 9 121763735 121763879 145 + 1.821 1.778 -0.147
ENSG00000136848 E027 80.4061758 0.0003474528 1.600574e-03 5.962988e-03 9 121766494 121766730 237 + 1.926 1.869 -0.193
ENSG00000136848 E028 81.5756638 0.0007502133 2.188583e-05 1.344328e-04 9 121768432 121768633 202 + 1.961 1.858 -0.346
ENSG00000136848 E029 69.8945085 0.0020070236 5.256209e-03 1.662753e-02 9 121770546 121770724 179 + 1.867 1.805 -0.210
ENSG00000136848 E030 29.7872758 0.0065891868 2.948787e-01 4.359872e-01 9 121772607 121772672 66 + 1.471 1.461 -0.033
ENSG00000136848 E031 161.7379920 0.0030916934 1.129549e-01 2.098555e-01 9 121772673 121773495 823 + 2.183 2.196 0.045
ENSG00000136848 E032 91.5813797 0.0004595287 4.420680e-01 5.837349e-01 9 121774260 121774412 153 + 1.920 1.959 0.130
ENSG00000136848 E033 111.6956435 0.0002848993 6.184275e-01 7.360614e-01 9 121776198 121776391 194 + 1.974 2.059 0.288
ENSG00000136848 E034 83.9944823 0.0013564184 2.008160e-01 3.272038e-01 9 121781464 121781551 88 + 1.831 1.955 0.416
ENSG00000136848 E035 82.5811893 0.0067572156 7.055002e-01 8.038543e-01 9 121782331 121782401 71 + 1.848 1.940 0.309
ENSG00000136848 E036 215.5380079 0.0019380771 1.820110e-01 3.037397e-01 9 121782402 121783535 1134 + 2.241 2.355 0.382
ENSG00000136848 E037 686.7110661 0.0079128237 5.582794e-11 1.027836e-09 9 121783536 121785530 1995 + 2.609 2.911 1.004