ENSG00000136830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373312 ENSG00000136830 HEK293_OSMI2_2hA HEK293_TMG_2hB NIBAN2 protein_coding protein_coding 35.01511 60.23383 22.35873 4.015175 0.3343795 -1.42933 23.89207 35.49386 21.18866 5.614220 0.2212245 -0.7440028 0.7101625 0.5822667 0.9479667 0.3657000 3.193093e-08 1.472527e-25 FALSE TRUE
ENST00000373314 ENSG00000136830 HEK293_OSMI2_2hA HEK293_TMG_2hB NIBAN2 protein_coding protein_coding 35.01511 60.23383 22.35873 4.015175 0.3343795 -1.42933 9.81215 23.82876 0.00000 2.318146 0.0000000 -11.2190936 0.2436417 0.4030333 0.0000000 -0.4030333 1.472527e-25 1.472527e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136830 E001 1.472624 0.0095779387 6.044819e-02 1.273815e-01 9 127505339 127505342 4 - 0.001 0.404 10.187
ENSG00000136830 E002 153.655468 0.0030832621 3.044672e-03 1.039736e-02 9 127505343 127505494 152 - 1.994 2.139 0.487
ENSG00000136830 E003 1928.405801 0.0034859799 2.797335e-06 2.108318e-05 9 127505495 127506875 1381 - 3.099 3.233 0.446
ENSG00000136830 E004 556.814183 0.0002915604 2.259398e-08 2.608069e-07 9 127506876 127507171 296 - 2.563 2.686 0.409
ENSG00000136830 E005 129.919855 0.0017068069 6.642431e-03 2.029561e-02 9 127507172 127507183 12 - 1.926 2.056 0.439
ENSG00000136830 E006 469.264016 0.0003230504 2.369287e-07 2.238340e-06 9 127507184 127507431 248 - 2.490 2.613 0.410
ENSG00000136830 E007 284.145734 0.0002550926 9.310726e-03 2.705849e-02 9 127507867 127507934 68 - 2.308 2.388 0.265
ENSG00000136830 E008 251.985372 0.0005521054 8.629429e-01 9.156293e-01 9 127507935 127507978 44 - 2.303 2.321 0.058
ENSG00000136830 E009 373.205329 0.0001538017 3.324341e-01 4.760866e-01 9 127508093 127508200 108 - 2.462 2.495 0.110
ENSG00000136830 E010 238.049748 0.0001856926 2.440234e-01 3.789303e-01 9 127508422 127508445 24 - 2.260 2.303 0.146
ENSG00000136830 E011 406.896700 0.0007769372 8.955904e-01 9.373086e-01 9 127508446 127508538 93 - 2.521 2.531 0.034
ENSG00000136830 E012 528.804385 0.0002616638 2.230924e-01 3.540811e-01 9 127508976 127509131 156 - 2.650 2.639 -0.036
ENSG00000136830 E013 9.430452 0.0018032099 8.751192e-03 2.566329e-02 9 127509888 127510145 258 - 1.136 0.855 -1.043
ENSG00000136830 E014 489.364392 0.0001319349 3.160824e-02 7.509231e-02 9 127510146 127510333 188 - 2.629 2.600 -0.095
ENSG00000136830 E015 354.144385 0.0005993089 9.183763e-01 9.524321e-01 9 127516857 127517019 163 - 2.455 2.470 0.050
ENSG00000136830 E016 364.637336 0.0014452286 7.725177e-02 1.550815e-01 9 127517112 127517216 105 - 2.506 2.472 -0.114
ENSG00000136830 E017 385.056263 0.0027253294 3.417936e-03 1.149098e-02 9 127517826 127517941 116 - 2.563 2.486 -0.256
ENSG00000136830 E018 436.934707 0.0023076051 9.050211e-05 4.773737e-04 9 127523679 127523846 168 - 2.633 2.535 -0.327
ENSG00000136830 E019 1.250223 0.1002706343 3.579528e-01 5.023495e-01 9 127524806 127525057 252 - 0.424 0.250 -1.083
ENSG00000136830 E020 359.993362 0.0011244242 5.703373e-08 6.070770e-07 9 127525058 127525163 106 - 2.567 2.442 -0.418
ENSG00000136830 E021 348.968984 0.0014939981 7.503127e-08 7.807134e-07 9 127527194 127527322 129 - 2.560 2.427 -0.444
ENSG00000136830 E022 217.166847 0.0026216579 7.353504e-05 3.971320e-04 9 127531648 127531724 77 - 2.350 2.223 -0.424
ENSG00000136830 E023 176.156951 0.0009122383 4.729026e-08 5.127338e-07 9 127531725 127531778 54 - 2.284 2.120 -0.547
ENSG00000136830 E024 1.141582 0.0144646662 6.151971e-01 7.335246e-01 9 127561148 127561237 90 - 0.191 0.293 0.805
ENSG00000136830 E025 154.418786 0.0062216689 8.248898e-06 5.586562e-05 9 127568820 127568914 95 - 2.254 2.055 -0.666
ENSG00000136830 E026 77.122745 0.0048314012 4.720263e-07 4.196535e-06 9 127568915 127569076 162 - 1.991 1.735 -0.865
ENSG00000136830 E027 0.000000       9 127578922 127578989 68 -