ENSG00000136828

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319107 ENSG00000136828 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS1 protein_coding protein_coding 3.765485 3.98054 3.164213 0.6532963 0.4588984 -0.3301852 0.2746434 0.44715325 0.02913111 0.19063661 0.02913111 -3.546290 0.07185000 0.1041667 0.0072000 -0.09696667 3.178427e-02 1.021575e-08 FALSE FALSE
ENST00000373434 ENSG00000136828 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS1 protein_coding protein_coding 3.765485 3.98054 3.164213 0.6532963 0.4588984 -0.3301852 0.2830924 0.07310704 0.43674355 0.07310704 0.24067814 2.426404 0.07909167 0.0236000 0.1337667 0.11016667 5.251126e-01 1.021575e-08 FALSE TRUE
ENST00000424082 ENSG00000136828 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS1 protein_coding protein_coding 3.765485 3.98054 3.164213 0.6532963 0.4588984 -0.3301852 0.1985993 0.24216703 0.58304481 0.24216703 0.19761838 1.233761 0.06613333 0.0675000 0.2070000 0.13950000 2.573476e-01 1.021575e-08 FALSE TRUE
ENST00000438723 ENSG00000136828 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS1 protein_coding protein_coding 3.765485 3.98054 3.164213 0.6532963 0.4588984 -0.3301852 0.4000057 0.31603219 0.00000000 0.31603219 0.00000000 -5.026943 0.08566667 0.0881000 0.0000000 -0.08810000 8.461977e-01 1.021575e-08 FALSE FALSE
MSTRG.33405.11 ENSG00000136828 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS1 protein_coding   3.765485 3.98054 3.164213 0.6532963 0.4588984 -0.3301852 0.4698017 0.60081299 0.00000000 0.47640294 0.00000000 -5.932659 0.12389583 0.1824000 0.0000000 -0.18240000 2.927682e-01 1.021575e-08 FALSE TRUE
MSTRG.33405.13 ENSG00000136828 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS1 protein_coding   3.765485 3.98054 3.164213 0.6532963 0.4588984 -0.3301852 0.7034858 0.75255892 0.00000000 0.11494821 0.00000000 -6.252777 0.18536667 0.1969000 0.0000000 -0.19690000 1.021575e-08 1.021575e-08 FALSE TRUE
MSTRG.33405.6 ENSG00000136828 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS1 protein_coding   3.765485 3.98054 3.164213 0.6532963 0.4588984 -0.3301852 0.6710038 0.65596416 1.52572758 0.33416829 0.03052271 1.205406 0.20017500 0.1505667 0.5035333 0.35296667 2.556060e-01 1.021575e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136828 E001 0.1451727 0.0420757599 0.4338071688   9 126914774 126914781 8 + 0.130 0.000 -10.459
ENSG00000136828 E002 0.2924217 0.0290785164 0.1678597824   9 126914782 126914785 4 + 0.229 0.000 -13.786
ENSG00000136828 E003 0.5138669 0.0201589493 0.4947137840 0.631651743 9 126914786 126914789 4 + 0.229 0.115 -1.192
ENSG00000136828 E004 0.8126314 0.0141047479 0.1302082214 0.234455464 9 126914790 126914794 5 + 0.379 0.115 -2.193
ENSG00000136828 E005 1.6920866 0.0080150332 0.0020182178 0.007282490 9 126914795 126914805 11 + 0.651 0.115 -3.515
ENSG00000136828 E006 2.1317573 0.0072821663 0.0002433384 0.001147301 9 126914806 126914826 21 + 0.742 0.115 -3.894
ENSG00000136828 E007 2.1317573 0.0072821663 0.0002433384 0.001147301 9 126914827 126914831 5 + 0.742 0.115 -3.894
ENSG00000136828 E008 2.1317573 0.0072821663 0.0002433384 0.001147301 9 126914832 126914839 8 + 0.742 0.115 -3.894
ENSG00000136828 E009 2.6456243 0.0210154742 0.0006206797 0.002609045 9 126914840 126914850 11 + 0.794 0.207 -3.096
ENSG00000136828 E010 3.6023075 0.0043696327 0.0089347070 0.026115150 9 126914851 126914928 78 + 0.840 0.451 -1.697
ENSG00000136828 E011 3.8686017 0.0044367450 0.2597131418 0.397167269 9 126914929 126914975 47 + 0.769 0.607 -0.680
ENSG00000136828 E012 4.6489757 0.0037450661 0.5383305662 0.669760564 9 126914976 126914997 22 + 0.684 0.769 0.347
ENSG00000136828 E013 4.1717292 0.0057080793 0.6255314531 0.741626230 9 126914998 126915012 15 + 0.651 0.722 0.293
ENSG00000136828 E014 0.0000000       9 126915450 126915476 27 +      
ENSG00000136828 E015 12.4390949 0.0015179985 0.9070345311 0.944999730 9 126962225 126962346 122 + 1.131 1.119 -0.043
ENSG00000136828 E016 15.3018624 0.0165842445 0.4855600562 0.623435418 9 126965844 126965951 108 + 1.256 1.181 -0.264
ENSG00000136828 E017 13.1827655 0.0029863646 0.9573012765 0.977233124 9 126977695 126977745 51 + 1.153 1.157 0.015
ENSG00000136828 E018 0.0000000       9 126977746 126978306 561 +      
ENSG00000136828 E019 0.7748771 0.1680552772 0.0505024429 0.110056470 9 126989893 126990223 331 + 0.000 0.394 13.460
ENSG00000136828 E020 0.4417591 0.0884020170 0.6696531057 0.776383440 9 127016660 127016961 302 + 0.130 0.205 0.792
ENSG00000136828 E021 18.2278433 0.0011247368 0.5765278474 0.701937475 9 127034431 127034514 84 + 1.248 1.291 0.152
ENSG00000136828 E022 8.8791530 0.0044505109 0.3219196881 0.465189158 9 127050043 127050055 13 + 1.045 0.935 -0.407
ENSG00000136828 E023 14.9016066 0.0075038231 0.6283867809 0.743928229 9 127050056 127050132 77 + 1.222 1.176 -0.163
ENSG00000136828 E024 19.6984055 0.0012082017 0.3462314035 0.490378223 9 127052847 127052939 93 + 1.265 1.336 0.250
ENSG00000136828 E025 22.7604452 0.0129929595 0.6546038319 0.764750662 9 127069230 127069356 127 + 1.392 1.350 -0.145
ENSG00000136828 E026 0.3030308 0.4282735946 0.2615079075   9 127069357 127070000 644 + 0.230 0.000 -12.916
ENSG00000136828 E027 0.0000000       9 127079601 127079853 253 +      
ENSG00000136828 E028 23.6982553 0.0230406946 0.2721702317 0.411021570 9 127166069 127166206 138 + 1.449 1.340 -0.378
ENSG00000136828 E029 22.0609624 0.0142329818 0.2294282759 0.361752290 9 127168679 127168772 94 + 1.416 1.311 -0.366
ENSG00000136828 E030 16.4927003 0.0093784082 0.1986764920 0.324530004 9 127174715 127174782 68 + 1.304 1.184 -0.421
ENSG00000136828 E031 0.5514428 0.0197411573 0.1056221956 0.199045132 9 127177897 127178426 530 + 0.000 0.282 13.258
ENSG00000136828 E032 0.2965864 0.2035599597 0.2924029894   9 127183867 127184336 470 + 0.000 0.203 12.172
ENSG00000136828 E033 24.9581561 0.0015315530 0.1957480869 0.320900364 9 127195091 127195217 127 + 1.460 1.371 -0.307
ENSG00000136828 E034 14.7869575 0.0069668740 0.4817082365 0.619905717 9 127196474 127196631 158 + 1.153 1.218 0.231
ENSG00000136828 E035 6.8721908 0.0029323855 0.0244547948 0.060759180 9 127199015 127199066 52 + 0.714 0.992 1.078
ENSG00000136828 E036 0.4482035 0.0323730315 0.0670315022 0.138433464 9 127210503 127210525 23 + 0.311 0.000 -14.308
ENSG00000136828 E037 9.4573354 0.0019274685 0.9819859298 0.992738805 9 127210695 127210697 3 + 1.017 1.018 0.005
ENSG00000136828 E038 15.9297877 0.0011743630 0.5613648947 0.689201605 9 127210698 127210744 47 + 1.194 1.241 0.168
ENSG00000136828 E039 16.1471951 0.0088218010 0.7787432235 0.857646104 9 127210745 127210778 34 + 1.213 1.235 0.078
ENSG00000136828 E040 25.5854856 0.0045220209 0.3157135410 0.458483550 9 127212131 127212236 106 + 1.367 1.440 0.254
ENSG00000136828 E041 19.1115598 0.0027156827 0.2092369504 0.337605823 9 127212627 127212675 49 + 1.231 1.331 0.350
ENSG00000136828 E042 19.0655795 0.0166098531 0.5627428406 0.690300071 9 127212676 127212719 44 + 1.265 1.313 0.170
ENSG00000136828 E043 11.5728554 0.0020022807 0.9537440699 0.975025648 9 127212944 127212967 24 + 1.084 1.089 0.016
ENSG00000136828 E044 18.2071154 0.0039008037 0.2035002397 0.330593657 9 127212968 127213049 82 + 1.213 1.318 0.369
ENSG00000136828 E045 22.7573553 0.0008997255 0.2313164973 0.364050513 9 127214751 127214842 92 + 1.319 1.404 0.295
ENSG00000136828 E046 26.3163088 0.0017589182 0.3397653002 0.483694990 9 127216906 127217812 907 + 1.392 1.457 0.225
ENSG00000136828 E047 196.3861706 0.0039030953 0.2349418926 0.368284204 9 127218740 127223166 4427 + 2.266 2.305 0.130