ENSG00000136738

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377524 ENSG00000136738 HEK293_OSMI2_2hA HEK293_TMG_2hB STAM protein_coding protein_coding 10.88812 4.628535 16.98459 0.2204706 1.01441 1.873334 4.1215672 3.4807855 4.554424 0.5605841 0.2223903 0.3868812 0.47580833 0.75533333 0.2707333 -0.48460000 0.005013872 0.0009301328 FALSE TRUE
MSTRG.3618.1 ENSG00000136738 HEK293_OSMI2_2hA HEK293_TMG_2hB STAM protein_coding   10.88812 4.628535 16.98459 0.2204706 1.01441 1.873334 5.5818997 0.9931362 10.062431 0.4669478 0.6651830 3.3278226 0.42531250 0.21230000 0.5920000 0.37970000 0.009770939 0.0009301328 FALSE TRUE
MSTRG.3618.3 ENSG00000136738 HEK293_OSMI2_2hA HEK293_TMG_2hB STAM protein_coding   10.88812 4.628535 16.98459 0.2204706 1.01441 1.873334 0.6910975 0.1124276 1.224190 0.1124276 0.3738575 3.3335631 0.06062917 0.02363333 0.0709000 0.04726667 0.310622068 0.0009301328 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136738 E001 8.8458145 0.0018854861 1.068888e-01 2.009502e-01 10 17644151 17644196 46 + 1.011 0.839 -0.650
ENSG00000136738 E002 14.8393043 0.0011581770 3.498016e-01 4.940029e-01 10 17644197 17644207 11 + 1.187 1.125 -0.221
ENSG00000136738 E003 72.9548339 0.0003322285 3.527111e-04 1.590840e-03 10 17644208 17644379 172 + 1.874 1.738 -0.458
ENSG00000136738 E004 72.9392689 0.0003947344 2.204215e-02 5.576682e-02 10 17660464 17660548 85 + 1.857 1.782 -0.252
ENSG00000136738 E005 3.6569264 0.0042038003 6.696902e-02 1.383361e-01 10 17672975 17673078 104 + 0.711 0.417 -1.362
ENSG00000136738 E006 51.6022846 0.0004667993 1.300457e-01 2.342255e-01 10 17684675 17684750 76 + 1.705 1.653 -0.175
ENSG00000136738 E007 0.2966881 0.0269547774 6.140554e-01   10 17684785 17684831 47 + 0.144 0.000 -9.245
ENSG00000136738 E008 59.3889323 0.0004172925 4.133360e-02 9.349547e-02 10 17684832 17684927 96 + 1.771 1.698 -0.247
ENSG00000136738 E009 79.1546470 0.0139307918 7.699663e-01 8.514746e-01 10 17688027 17688173 147 + 1.870 1.869 -0.001
ENSG00000136738 E010 73.3490160 0.0155517252 5.709465e-01 6.973536e-01 10 17693222 17693312 91 + 1.843 1.821 -0.076
ENSG00000136738 E011 0.2903454 0.3195941923 7.226509e-01   10 17694926 17695048 123 + 0.144 0.000 -9.240
ENSG00000136738 E012 113.3524212 0.0021709874 1.052128e-03 4.139874e-03 10 17695049 17695241 193 + 2.055 1.944 -0.370
ENSG00000136738 E013 81.1136104 0.0045153348 6.883175e-02 1.414359e-01 10 17696775 17696869 95 + 1.903 1.838 -0.221
ENSG00000136738 E014 81.3401335 0.0130041201 9.097466e-02 1.766790e-01 10 17700191 17700279 89 + 1.908 1.831 -0.257
ENSG00000136738 E015 77.4509835 0.0003871373 1.747024e-01 2.943197e-01 10 17704431 17704518 88 + 1.872 1.843 -0.098
ENSG00000136738 E016 64.4237514 0.0003745638 3.864620e-01 5.306419e-01 10 17704970 17705024 55 + 1.786 1.775 -0.039
ENSG00000136738 E017 94.8039097 0.0003888037 1.606389e-01 2.759596e-01 10 17705588 17705741 154 + 1.921 2.004 0.277
ENSG00000136738 E018 85.9338522 0.0063916133 7.385824e-01 8.284324e-01 10 17708776 17708951 176 + 1.891 1.934 0.144
ENSG00000136738 E019 72.8840181 0.0058207295 1.075982e-01 2.019932e-01 10 17714543 17714678 136 + 1.797 1.911 0.384
ENSG00000136738 E020 281.5482595 0.0052599751 1.732955e-09 2.456808e-08 10 17714679 17716824 2146 + 2.331 2.567 0.788
ENSG00000136738 E021 0.3030308 0.3526974532 7.233952e-01   10 17733835 17733912 78 + 0.145 0.000 -9.252