ENSG00000136731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259253 ENSG00000136731 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT1 protein_coding protein_coding 15.51604 8.169729 20.22572 0.6984091 0.5956498 1.306779 9.3319750 6.94634263 10.07050246 0.47723469 0.15412058 0.5351667 0.68622500 0.854566667 0.4983666667 -0.35620000 2.599013e-03 2.109831e-17 FALSE TRUE
ENST00000376723 ENSG00000136731 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT1 protein_coding nonsense_mediated_decay 15.51604 8.169729 20.22572 0.6984091 0.5956498 1.306779 2.3822283 0.00000000 4.65766669 0.00000000 0.79562499 8.8665577 0.10765000 0.000000000 0.2287333333 0.22873333 2.109831e-17 2.109831e-17 FALSE TRUE
ENST00000418197 ENSG00000136731 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT1 protein_coding protein_coding 15.51604 8.169729 20.22572 0.6984091 0.5956498 1.306779 0.1893539 0.73537533 0.01836584 0.36902075 0.01836584 -4.7157406 0.02128333 0.087000000 0.0009333333 -0.08606667 1.581807e-01 2.109831e-17 FALSE FALSE
MSTRG.19188.1 ENSG00000136731 HEK293_OSMI2_2hA HEK293_TMG_2hB UGGT1 protein_coding   15.51604 8.169729 20.22572 0.6984091 0.5956498 1.306779 2.1736184 0.07889442 3.23024287 0.06014665 1.14164881 5.1878653 0.10020000 0.008633333 0.1628333333 0.15420000 8.187112e-03 2.109831e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136731 E001 1.1374321 0.0123751961 9.300448e-01 9.599719e-01 2 128091195 128091199 5 + 0.300 0.315 0.100
ENSG00000136731 E002 1.3191365 0.0114683461 6.599846e-01 7.686999e-01 2 128091200 128091203 4 + 0.300 0.415 0.685
ENSG00000136731 E003 1.6136345 0.0101929484 9.926364e-01 9.994821e-01 2 128091204 128091207 4 + 0.379 0.415 0.200
ENSG00000136731 E004 2.2027444 0.0079769887 4.696213e-01 6.088552e-01 2 128091208 128091210 3 + 0.503 0.415 -0.453
ENSG00000136731 E005 8.6922093 0.0048561365 4.175722e-02 9.428820e-02 2 128091211 128091244 34 + 1.006 0.801 -0.780
ENSG00000136731 E006 30.1697960 0.0015248504 1.641829e-07 1.599969e-06 2 128091245 128091382 138 + 1.542 1.187 -1.233
ENSG00000136731 E007 17.1487338 0.0072408963 4.295100e-04 1.888052e-03 2 128091383 128091397 15 + 1.299 0.980 -1.147
ENSG00000136731 E008 18.6517411 0.0013433804 4.784692e-05 2.708557e-04 2 128091398 128091415 18 + 1.336 1.002 -1.192
ENSG00000136731 E009 19.9560727 0.0012152319 9.131951e-08 9.337331e-07 2 128091416 128091596 181 + 1.392 0.927 -1.668
ENSG00000136731 E010 68.5569317 0.0003609888 1.885706e-18 1.004898e-16 2 128097429 128097564 136 + 1.900 1.489 -1.394
ENSG00000136731 E011 0.9514613 0.0735411813 4.871809e-01 6.248739e-01 2 128103079 128103145 67 + 0.300 0.186 -0.892
ENSG00000136731 E012 64.5827248 0.0003663346 2.881870e-21 2.126847e-19 2 128103932 128104014 83 + 1.885 1.406 -1.630
ENSG00000136731 E013 72.6313026 0.0003404521 8.843737e-26 1.041927e-23 2 128107938 128108068 131 + 1.939 1.424 -1.750
ENSG00000136731 E014 81.7522905 0.0003062762 3.136971e-27 4.138508e-25 2 128109634 128109746 113 + 1.988 1.496 -1.666
ENSG00000136731 E015 94.1793151 0.0028195458 9.051538e-17 3.922202e-15 2 128113084 128113258 175 + 2.032 1.655 -1.270
ENSG00000136731 E016 71.6522513 0.0101064932 6.823422e-07 5.872067e-06 2 128115124 128115213 90 + 1.900 1.612 -0.972
ENSG00000136731 E017 37.7373139 0.0023640480 1.040529e-07 1.053357e-06 2 128115214 128115220 7 + 1.631 1.305 -1.123
ENSG00000136731 E018 67.5275594 0.0003837850 4.746606e-09 6.221755e-08 2 128116265 128116343 79 + 1.862 1.629 -0.790
ENSG00000136731 E019 82.0461653 0.0307448183 3.767791e-02 8.672686e-02 2 128120356 128120456 101 + 1.919 1.802 -0.395
ENSG00000136731 E020 79.5573259 0.0182627202 7.316207e-04 3.012985e-03 2 128121199 128121298 100 + 1.926 1.724 -0.681
ENSG00000136731 E021 72.8823260 0.0003986597 9.257208e-12 1.939989e-10 2 128123186 128123246 61 + 1.904 1.629 -0.931
ENSG00000136731 E022 90.0031368 0.0003128439 4.888006e-17 2.180405e-15 2 128127361 128127452 92 + 2.003 1.685 -1.073
ENSG00000136731 E023 113.9443794 0.0006375715 1.604773e-12 3.799292e-11 2 128129029 128129179 151 + 2.084 1.863 -0.743
ENSG00000136731 E024 86.5916858 0.0013049081 2.484472e-08 2.843276e-07 2 128133141 128133260 120 + 1.963 1.763 -0.672
ENSG00000136731 E025 73.9510491 0.0008660012 3.188775e-09 4.305187e-08 2 128134876 128134961 86 + 1.902 1.670 -0.783
ENSG00000136731 E026 103.7453158 0.0104450497 3.395426e-06 2.511911e-05 2 128138717 128138852 136 + 2.048 1.805 -0.816
ENSG00000136731 E027 118.6406813 0.0017763663 5.636683e-08 6.004907e-07 2 128143094 128143225 132 + 2.088 1.920 -0.565
ENSG00000136731 E028 0.8576959 0.3025360904 5.979498e-01 7.196298e-01 2 128145652 128145802 151 + 0.204 0.320 0.859
ENSG00000136731 E029 129.1731957 0.0003323666 2.977295e-09 4.041267e-08 2 128145803 128145967 165 + 2.122 1.971 -0.505
ENSG00000136731 E030 102.9861261 0.0003003071 3.443674e-07 3.147403e-06 2 128152784 128152904 121 + 2.024 1.884 -0.469
ENSG00000136731 E031 78.8163009 0.0003628507 6.214903e-05 3.420571e-04 2 128155489 128155587 99 + 1.901 1.783 -0.398
ENSG00000136731 E032 53.7782450 0.0004841613 1.156765e-04 5.940473e-04 2 128156392 128156415 24 + 1.744 1.595 -0.507
ENSG00000136731 E033 80.6646124 0.0003052264 1.549023e-02 4.160692e-02 2 128157252 128157346 95 + 1.892 1.850 -0.143
ENSG00000136731 E034 111.4719387 0.0002541100 2.154762e-04 1.030399e-03 2 128159514 128159720 207 + 2.041 1.966 -0.252
ENSG00000136731 E035 70.6749906 0.0003666680 3.053334e-03 1.042300e-02 2 128160460 128160539 80 + 1.846 1.771 -0.255
ENSG00000136731 E036 67.9179665 0.0003820887 2.989434e-02 7.175756e-02 2 128160540 128160591 52 + 1.819 1.779 -0.134
ENSG00000136731 E037 110.4010206 0.0002595860 8.929839e-04 3.589728e-03 2 128161138 128161268 131 + 2.033 1.971 -0.206
ENSG00000136731 E038 113.9070414 0.0008205535 5.096673e-03 1.619424e-02 2 128164730 128164825 96 + 2.042 1.998 -0.149
ENSG00000136731 E039 116.0381694 0.0002592964 4.330221e-03 1.406969e-02 2 128170288 128170390 103 + 2.048 2.007 -0.136
ENSG00000136731 E040 96.1649593 0.0048905372 2.236510e-02 5.643841e-02 2 128171205 128171284 80 + 1.970 1.912 -0.196
ENSG00000136731 E041 0.3030308 0.3558942077 6.619289e-01   2 128171285 128171390 106 + 0.146 0.001 -7.738
ENSG00000136731 E042 125.5710801 0.0004759120 6.193722e-03 1.912447e-02 2 128172573 128172762 190 + 2.078 2.042 -0.119
ENSG00000136731 E043 101.6812818 0.0002896060 5.107459e-01 6.459133e-01 2 128173781 128173939 159 + 1.965 2.002 0.125
ENSG00000136731 E044 75.6978978 0.0003461451 8.245989e-01 8.895173e-01 2 128174773 128174858 86 + 1.830 1.902 0.241
ENSG00000136731 E045 85.7788743 0.0003160331 3.766571e-01 5.209687e-01 2 128176814 128176898 85 + 1.899 1.924 0.087
ENSG00000136731 E046 102.8891136 0.0008865532 2.348580e-01 3.681805e-01 2 128177832 128177920 89 + 1.980 1.995 0.052
ENSG00000136731 E047 110.6620179 0.0042910727 8.306156e-01 8.937525e-01 2 128178468 128178569 102 + 1.998 2.052 0.184
ENSG00000136731 E048 83.7741606 0.0003178078 6.993984e-03 2.120865e-02 2 128179786 128179870 85 + 1.837 2.007 0.573
ENSG00000136731 E049 142.3998029 0.0002408063 8.186754e-03 2.425719e-02 2 128180890 128181072 183 + 2.075 2.220 0.484
ENSG00000136731 E050 145.2065682 0.0046285245 6.374660e-02 1.329343e-01 2 128182130 128182290 161 + 2.084 2.230 0.489
ENSG00000136731 E051 134.0130255 0.0002948813 6.037214e-02 1.272439e-01 2 128183675 128183789 115 + 2.058 2.181 0.412
ENSG00000136731 E052 149.4859333 0.0002331828 4.793791e-03 1.535779e-02 2 128186683 128186799 117 + 2.094 2.242 0.495
ENSG00000136731 E053 0.0000000       2 128187237 128187319 83 +      
ENSG00000136731 E054 154.7305180 0.0030161229 2.390186e-04 1.129126e-03 2 128187449 128187614 166 + 2.085 2.288 0.679
ENSG00000136731 E055 629.3174349 0.0001099764 1.931968e-32 3.874543e-30 2 128189717 128191582 1866 + 2.680 2.913 0.774
ENSG00000136731 E056 532.0124496 0.0027530768 5.315187e-32 1.024360e-29 2 128191583 128193536 1954 + 2.533 2.921 1.290
ENSG00000136731 E057 539.7815130 0.0127799906 1.209099e-13 3.397008e-12 2 128193537 128195677 2141 + 2.502 2.958 1.517