ENSG00000136717

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348750 ENSG00000136717 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN1 protein_coding protein_coding 15.30884 28.86888 9.466493 0.8760812 0.1148179 -1.607589 4.1401620 8.8281782 3.0875836 0.19917417 0.42538656 -1.5126058 0.2683583 0.30596667 0.32533333 0.019366667 9.021320e-01 1.111649e-09 FALSE  
ENST00000393040 ENSG00000136717 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN1 protein_coding protein_coding 15.30884 28.86888 9.466493 0.8760812 0.1148179 -1.607589 2.8751505 5.0174932 1.5831092 0.31574642 0.21986978 -1.6579941 0.1941000 0.17460000 0.16743333 -0.007166667 9.505845e-01 1.111649e-09 FALSE  
ENST00000409400 ENSG00000136717 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN1 protein_coding protein_coding 15.30884 28.86888 9.466493 0.8760812 0.1148179 -1.607589 4.9888493 8.9628624 3.1004867 0.54627532 0.13355890 -1.5284279 0.3125458 0.31046667 0.32796667 0.017500000 8.571702e-01 1.111649e-09 FALSE  
ENST00000462958 ENSG00000136717 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN1 protein_coding retained_intron 15.30884 28.86888 9.466493 0.8760812 0.1148179 -1.607589 0.6704560 0.5638851 0.3852019 0.04695299 0.01308273 -0.5381719 0.0533875 0.01946667 0.04073333 0.021266667 3.539535e-02 1.111649e-09 TRUE  
ENST00000484253 ENSG00000136717 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN1 protein_coding processed_transcript 15.30884 28.86888 9.466493 0.8760812 0.1148179 -1.607589 0.5244612 1.7122521 0.0000000 0.33998955 0.00000000 -7.4281525 0.0267000 0.05900000 0.00000000 -0.059000000 1.111649e-09 1.111649e-09 FALSE  
MSTRG.19164.13 ENSG00000136717 HEK293_OSMI2_2hA HEK293_TMG_2hB BIN1 protein_coding   15.30884 28.86888 9.466493 0.8760812 0.1148179 -1.607589 1.8952430 3.5172709 1.2084375 0.44150433 0.41888605 -1.5335202 0.1279250 0.12120000 0.12786667 0.006666667 9.872325e-01 1.111649e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136717 E001 0.8877700 0.0287776095 2.213842e-01 3.520809e-01 2 127048027 127048031 5 - 0.000 0.279 9.729
ENSG00000136717 E002 0.8877700 0.0287776095 2.213842e-01 3.520809e-01 2 127048032 127048032 1 - 0.000 0.279 11.742
ENSG00000136717 E003 3.6104543 0.0048009476 2.018351e-02 5.186655e-02 2 127048033 127048037 5 - 0.200 0.664 2.623
ENSG00000136717 E004 28.4517770 0.0007700467 3.809766e-01 5.252592e-01 2 127048038 127048104 67 - 1.321 1.395 0.259
ENSG00000136717 E005 414.6935725 0.0014732224 1.172778e-09 1.715588e-08 2 127048105 127048633 529 - 2.383 2.554 0.573
ENSG00000136717 E006 0.0000000       2 127050382 127050407 26 -      
ENSG00000136717 E007 0.1482932 0.0412145306 1.000000e+00   2 127050408 127050420 13 - 0.000 0.072 9.354
ENSG00000136717 E008 203.0150102 0.0003054277 1.231939e-03 4.748932e-03 2 127050421 127050522 102 - 2.127 2.234 0.356
ENSG00000136717 E009 192.6462879 0.0002248323 1.109177e-04 5.720910e-04 2 127050802 127050912 111 - 2.085 2.215 0.433
ENSG00000136717 E010 98.5921958 0.0002906792 1.181648e-02 3.309623e-02 2 127051154 127051243 90 - 1.804 1.922 0.397
ENSG00000136717 E011 2.6915123 0.0595762044 7.859504e-01 8.629248e-01 2 127052255 127052362 108 - 0.441 0.503 0.314
ENSG00000136717 E012 17.0652221 0.0014465805 1.811378e-01 3.026477e-01 2 127052363 127053421 1059 - 1.255 1.135 -0.426
ENSG00000136717 E013 2.7303383 0.0056447318 2.251777e-02 5.675640e-02 2 127053422 127053445 24 - 0.755 0.389 -1.696
ENSG00000136717 E014 8.9700568 0.0021313841 3.935495e-03 1.296076e-02 2 127053446 127053904 459 - 1.143 0.820 -1.202
ENSG00000136717 E015 4.1705978 0.0039178269 2.504765e-02 6.197289e-02 2 127053905 127054012 108 - 0.872 0.548 -1.350
ENSG00000136717 E016 33.2423471 0.0006493534 6.365388e-09 8.148548e-08 2 127054013 127056491 2479 - 1.701 1.338 -1.244
ENSG00000136717 E017 68.2089038 0.0003980992 5.918761e-02 1.252406e-01 2 127057473 127057601 129 - 1.658 1.764 0.358
ENSG00000136717 E018 223.9252898 0.0002517576 1.566980e-01 2.707017e-01 2 127059011 127059155 145 - 2.281 2.247 -0.114
ENSG00000136717 E019 0.0000000       2 127060596 127060640 45 -      
ENSG00000136717 E020 187.8470368 0.0002170937 6.115530e-03 1.891078e-02 2 127062115 127062197 83 - 2.239 2.163 -0.255
ENSG00000136717 E021 185.5650658 0.0002349507 1.092546e-01 2.044531e-01 2 127063571 127063646 76 - 2.207 2.163 -0.146
ENSG00000136717 E022 217.0785018 0.0003472179 6.483651e-02 1.347716e-01 2 127063933 127064018 86 - 2.281 2.234 -0.157
ENSG00000136717 E023 2.6025910 0.0265505912 1.407306e-02 3.839031e-02 2 127064774 127064928 155 - 0.000 0.549 13.191
ENSG00000136717 E024 3.4516814 0.1209403683 9.253568e-01 9.570101e-01 2 127068163 127068255 93 - 0.594 0.584 -0.046
ENSG00000136717 E025 235.2865377 0.0002428732 3.520587e-02 8.203546e-02 2 127068924 127069031 108 - 2.318 2.267 -0.171
ENSG00000136717 E026 218.5169043 0.0002083162 5.321428e-02 1.148777e-01 2 127069995 127070090 96 - 2.283 2.235 -0.162
ENSG00000136717 E027 198.5466259 0.0003261924 6.972002e-02 1.429016e-01 2 127070553 127070647 95 - 2.240 2.192 -0.163
ENSG00000136717 E028 146.0042794 0.0020403220 7.004952e-01 7.999537e-01 2 127070762 127070816 55 - 2.079 2.069 -0.034
ENSG00000136717 E029 136.3249133 0.0032091682 9.443196e-01 9.691091e-01 2 127076626 127076706 81 - 2.034 2.043 0.030
ENSG00000136717 E030 108.1041123 0.0040479747 1.184918e-02 3.317115e-02 2 127106860 127107575 716 - 2.030 1.914 -0.388