ENSG00000136715

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259235 ENSG00000136715 HEK293_OSMI2_2hA HEK293_TMG_2hB SAP130 protein_coding protein_coding 24.45017 31.24674 22.66885 1.257046 0.0312165 -0.4628193 5.0653364 6.969895 1.5387988 0.1602109 0.77450687 -2.1720556 0.19930000 0.22416667 0.067800000 -0.15636667 4.334732e-01 4.144835e-35 FALSE TRUE
ENST00000357702 ENSG00000136715 HEK293_OSMI2_2hA HEK293_TMG_2hB SAP130 protein_coding protein_coding 24.45017 31.24674 22.66885 1.257046 0.0312165 -0.4628193 6.7920231 11.512105 7.8271235 1.2644987 1.04217652 -0.5560082 0.26777083 0.37283333 0.345433333 -0.02740000 9.128880e-01 4.144835e-35 FALSE TRUE
ENST00000643581 ENSG00000136715 HEK293_OSMI2_2hA HEK293_TMG_2hB SAP130 protein_coding protein_coding 24.45017 31.24674 22.66885 1.257046 0.0312165 -0.4628193 8.4915648 9.382583 7.5082896 2.5437956 0.98505669 -0.3211175 0.35657917 0.29490000 0.331100000 0.03620000 8.666721e-01 4.144835e-35 FALSE TRUE
MSTRG.19185.10 ENSG00000136715 HEK293_OSMI2_2hA HEK293_TMG_2hB SAP130 protein_coding   24.45017 31.24674 22.66885 1.257046 0.0312165 -0.4628193 2.3663648 0.000000 3.9054961 0.0000000 0.39943535 8.6130513 0.10990417 0.00000000 0.172333333 0.17233333 4.144835e-35 4.144835e-35 FALSE TRUE
MSTRG.19185.6 ENSG00000136715 HEK293_OSMI2_2hA HEK293_TMG_2hB SAP130 protein_coding   24.45017 31.24674 22.66885 1.257046 0.0312165 -0.4628193 0.4966153 2.010273 0.1526183 0.4586796 0.07771614 -3.6349889 0.01686667 0.06366667 0.006733333 -0.05693333 5.137115e-03 4.144835e-35 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136715 E001 0.5931727 0.7140929881 4.073063e-01 5.508846e-01 2 127941217 127941217 1 - 0.000 0.291 10.656
ENSG00000136715 E002 0.8146179 0.1911587643 1.011916e-01 1.922928e-01 2 127941218 127941221 4 - 0.000 0.356 13.810
ENSG00000136715 E003 3.1363046 0.1653966133 1.563555e-01 2.702752e-01 2 127941222 127941223 2 - 0.346 0.702 1.726
ENSG00000136715 E004 345.1144452 0.0062170623 4.480773e-08 4.878277e-07 2 127941224 127941500 277 - 2.340 2.589 0.829
ENSG00000136715 E005 374.7372120 0.0047974062 2.125258e-10 3.542664e-09 2 127941501 127941673 173 - 2.368 2.626 0.859
ENSG00000136715 E006 135.9340127 0.0117955040 7.460268e-06 5.101521e-05 2 127941674 127941678 5 - 1.897 2.196 1.002
ENSG00000136715 E007 243.7695649 0.0046243473 3.079177e-10 5.001208e-09 2 127941679 127941755 77 - 2.170 2.443 0.913
ENSG00000136715 E008 722.1635050 0.0010350272 6.313575e-16 2.448491e-14 2 127941756 127942164 409 - 2.717 2.888 0.569
ENSG00000136715 E009 396.8187572 0.0005370792 3.533970e-11 6.721888e-10 2 127942424 127942537 114 - 2.469 2.622 0.510
ENSG00000136715 E010 308.7619526 0.0008861581 1.373945e-03 5.221775e-03 2 127945456 127945559 104 - 2.405 2.496 0.303
ENSG00000136715 E011 310.7815389 0.0010192287 1.074693e-02 3.056053e-02 2 127949869 127949994 126 - 2.421 2.497 0.253
ENSG00000136715 E012 420.6800633 0.0010624150 4.030256e-01 5.468166e-01 2 127950160 127950408 249 - 2.583 2.613 0.100
ENSG00000136715 E013 413.2222747 0.0004722012 4.391047e-01 5.808895e-01 2 127954986 127955344 359 - 2.598 2.592 -0.017
ENSG00000136715 E014 135.8884002 0.0002694482 9.240798e-02 1.788760e-01 2 127977985 127978089 105 - 2.140 2.097 -0.144
ENSG00000136715 E015 229.4527254 0.0002198037 2.444353e-02 6.073904e-02 2 127986785 127986959 175 - 2.369 2.324 -0.149
ENSG00000136715 E016 79.7773972 0.0007525140 1.339090e-01 2.395801e-01 2 127986960 127986962 3 - 1.919 1.866 -0.177
ENSG00000136715 E017 316.2602969 0.0001662409 5.629446e-09 7.280732e-08 2 127989564 127989866 303 - 2.547 2.438 -0.363
ENSG00000136715 E018 197.9917424 0.0002005367 1.725243e-07 1.674739e-06 2 127993187 127993308 122 - 2.353 2.228 -0.415
ENSG00000136715 E019 212.6809449 0.0017882236 1.828369e-05 1.144373e-04 2 127996350 127996491 142 - 2.383 2.259 -0.415
ENSG00000136715 E020 167.1107487 0.0043598812 5.297334e-02 1.144367e-01 2 127999741 127999845 105 - 2.246 2.176 -0.235
ENSG00000136715 E021 147.8495246 0.0058873814 3.620246e-02 8.397037e-02 2 128000056 128000146 91 - 2.204 2.118 -0.288
ENSG00000136715 E022 187.0758232 0.0074893976 1.101533e-03 4.308141e-03 2 128000307 128000451 145 - 2.341 2.196 -0.486
ENSG00000136715 E023 60.3365972 0.0004272380 3.920313e-09 5.207851e-08 2 128000452 128000454 3 - 1.917 1.660 -0.868
ENSG00000136715 E024 132.9499266 0.0070178011 3.819145e-05 2.212346e-04 2 128010269 128010350 82 - 2.224 2.029 -0.651
ENSG00000136715 E025 104.5498321 0.0164321913 9.885028e-03 2.848153e-02 2 128010351 128010393 43 - 2.105 1.938 -0.558
ENSG00000136715 E026 137.9054340 0.0052365829 2.283882e-03 8.101459e-03 2 128013030 128013148 119 - 2.202 2.073 -0.429
ENSG00000136715 E027 60.5605741 0.0028728340 4.837357e-02 1.062870e-01 2 128013149 128013154 6 - 1.826 1.734 -0.310
ENSG00000136715 E028 134.3246015 0.0029907286 1.151745e-04 5.917143e-04 2 128014803 128014914 112 - 2.197 2.054 -0.480
ENSG00000136715 E029 0.6696487 0.0280369683 1.452011e-01 2.551163e-01 2 128016388 128016388 1 - 0.347 0.100 -2.232
ENSG00000136715 E030 126.7232153 0.0062143382 1.392632e-07 1.376550e-06 2 128016389 128016472 84 - 2.229 1.983 -0.824
ENSG00000136715 E031 107.3732588 0.0073328719 2.756238e-08 3.125964e-07 2 128016473 128016547 75 - 2.178 1.894 -0.951
ENSG00000136715 E032 159.3695869 0.0102748163 1.381651e-07 1.366910e-06 2 128017680 128017915 236 - 2.346 2.064 -0.942
ENSG00000136715 E033 86.7199270 0.0114142864 5.757875e-05 3.195021e-04 2 128026181 128026298 118 - 2.066 1.822 -0.821
ENSG00000136715 E034 14.1859441 0.0034116316 8.011048e-06 5.439674e-05 2 128027092 128027257 166 - 1.377 0.981 -1.413
ENSG00000136715 E035 4.0773771 0.0365951969 5.649074e-03 1.768341e-02 2 128027258 128027313 56 - 0.921 0.489 -1.818
ENSG00000136715 E036 26.2864087 0.0250399935 3.589658e-03 1.198051e-02 2 128027940 128028219 280 - 1.572 1.294 -0.959