ENSG00000136709

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322313 ENSG00000136709 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR33 protein_coding protein_coding 23.11934 16.82301 28.47944 0.4841977 0.2165992 0.759134 4.987440 6.9392762 4.233862 0.3748602 0.3983860 -0.7114851 0.25577500 0.41443333 0.14860000 -0.26583333 5.250082e-08 5.250082e-08 FALSE TRUE
ENST00000409658 ENSG00000136709 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR33 protein_coding protein_coding 23.11934 16.82301 28.47944 0.4841977 0.2165992 0.759134 1.612994 0.8545954 1.961973 0.0488432 0.1196247 1.1895430 0.06633750 0.05080000 0.06886667 0.01806667 3.212504e-01 5.250082e-08 FALSE TRUE
ENST00000436787 ENSG00000136709 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR33 protein_coding protein_coding 23.11934 16.82301 28.47944 0.4841977 0.2165992 0.759134 1.960376 0.1894256 2.789961 0.1057243 0.5741601 3.8114838 0.06732917 0.01093333 0.09763333 0.08670000 2.543209e-03 5.250082e-08 FALSE FALSE
MSTRG.19174.1 ENSG00000136709 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR33 protein_coding   23.11934 16.82301 28.47944 0.4841977 0.2165992 0.759134 1.494297 0.6032446 1.701872 0.1761719 0.3613599 1.4810398 0.05804167 0.03546667 0.05996667 0.02450000 4.147956e-01 5.250082e-08 TRUE TRUE
MSTRG.19174.6 ENSG00000136709 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR33 protein_coding   23.11934 16.82301 28.47944 0.4841977 0.2165992 0.759134 12.075637 7.6968166 16.664156 0.5245430 0.1550086 1.1134068 0.50285000 0.45656667 0.58520000 0.12863333 1.549602e-03 5.250082e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136709 E001 2.331341 0.0086148275 9.909461e-01 9.984723e-01 2 127699287 127699319 33 - 0.505 0.520 0.070
ENSG00000136709 E002 4.969297 0.0326256278 3.062954e-01 4.484465e-01 2 127700609 127700709 101 - 0.686 0.855 0.680
ENSG00000136709 E003 3.456930 0.0490302949 4.308913e-01 5.734975e-01 2 127700710 127700777 68 - 0.574 0.719 0.624
ENSG00000136709 E004 3.090428 0.0073481699 4.708599e-01 6.100434e-01 2 127700778 127700864 87 - 0.661 0.567 -0.411
ENSG00000136709 E005 20.576929 0.0160681727 2.948571e-09 4.006296e-08 2 127701027 127701102 76 - 0.940 1.573 2.239
ENSG00000136709 E006 77.475004 0.0044770656 2.604939e-24 2.663237e-22 2 127701103 127701285 183 - 1.535 2.110 1.940
ENSG00000136709 E007 75.650785 0.0010773659 1.218222e-24 1.285014e-22 2 127701286 127701514 229 - 1.591 2.074 1.629
ENSG00000136709 E008 35.116416 0.0028842634 8.792251e-04 3.541106e-03 2 127701515 127701823 309 - 1.429 1.664 0.801
ENSG00000136709 E009 161.004768 0.0076564373 1.004460e-05 6.672230e-05 2 127701824 127702891 1068 - 2.076 2.321 0.818
ENSG00000136709 E010 120.742414 0.0045575609 1.467668e-04 7.331837e-04 2 127702892 127703623 732 - 1.980 2.175 0.656
ENSG00000136709 E011 1112.767565 0.0008721941 1.185400e-17 5.758218e-16 2 127703624 127706552 2929 - 2.964 3.126 0.540
ENSG00000136709 E012 457.300643 0.0070432635 7.955067e-05 4.257603e-04 2 127708677 127708892 216 - 2.561 2.753 0.640
ENSG00000136709 E013 275.556914 0.0053037158 1.260781e-03 4.845735e-03 2 127709490 127709582 93 - 2.363 2.518 0.519
ENSG00000136709 E014 285.435215 0.0039732390 1.848999e-03 6.755260e-03 2 127709693 127709856 164 - 2.387 2.525 0.460
ENSG00000136709 E015 501.651316 0.0006868533 6.111680e-06 4.266645e-05 2 127713583 127714021 439 - 2.645 2.757 0.372
ENSG00000136709 E016 221.636134 0.0001908503 9.401141e-06 6.288017e-05 2 127717155 127717263 109 - 2.281 2.412 0.437
ENSG00000136709 E017 934.747443 0.0001014726 1.469327e-01 2.575010e-01 2 127719265 127720353 1089 - 2.952 2.993 0.137
ENSG00000136709 E018 253.707737 0.0002459171 3.760060e-02 8.657941e-02 2 127721836 127721988 153 - 2.416 2.392 -0.080
ENSG00000136709 E019 289.824008 0.0021340532 4.672104e-03 1.501750e-02 2 127722591 127722730 140 - 2.491 2.428 -0.209
ENSG00000136709 E020 252.543341 0.0025740632 4.043670e-06 2.937576e-05 2 127722958 127723044 87 - 2.459 2.330 -0.432
ENSG00000136709 E021 262.102958 0.0020682410 1.568352e-09 2.243258e-08 2 127723253 127723347 95 - 2.488 2.324 -0.548
ENSG00000136709 E022 234.713120 0.0027819650 7.262725e-08 7.575716e-07 2 127724333 127724443 111 - 2.440 2.278 -0.543
ENSG00000136709 E023 183.413555 0.0004368563 4.307288e-08 4.706985e-07 2 127724887 127724965 79 - 2.320 2.191 -0.432
ENSG00000136709 E024 283.217427 0.0003017892 1.426076e-08 1.708397e-07 2 127725061 127725215 155 - 2.497 2.394 -0.344
ENSG00000136709 E025 128.691383 0.0002798387 7.954586e-04 3.243582e-03 2 127726651 127726651 1 - 2.147 2.063 -0.280
ENSG00000136709 E026 259.662563 0.0021712523 4.431478e-06 3.192008e-05 2 127726652 127726777 126 - 2.466 2.344 -0.408
ENSG00000136709 E027 24.287391 0.0263298310 5.466313e-01 6.767811e-01 2 127735388 127738054 2667 - 1.361 1.456 0.328
ENSG00000136709 E028 3.478226 0.0053806366 1.322982e-01 2.373078e-01 2 127762533 127763061 529 - 0.733 0.520 -0.931
ENSG00000136709 E029 237.824939 0.0001983722 1.304829e-14 4.224126e-13 2 127763062 127763159 98 - 2.443 2.282 -0.536
ENSG00000136709 E030 81.627634 0.0006797248 1.516240e-02 4.085438e-02 2 127763160 127764827 1668 - 1.951 1.876 -0.251
ENSG00000136709 E031 290.089312 0.0001707321 1.524670e-08 1.816859e-07 2 127764828 127764979 152 - 2.505 2.407 -0.325
ENSG00000136709 E032 197.916440 0.0002031988 5.713216e-08 6.078919e-07 2 127765174 127765269 96 - 2.348 2.231 -0.390
ENSG00000136709 E033 112.508957 0.0002672337 7.590813e-04 3.111801e-03 2 127768189 127768211 23 - 2.093 2.003 -0.304
ENSG00000136709 E034 173.751060 0.0002078962 7.631360e-08 7.928804e-07 2 127768212 127768293 82 - 2.296 2.171 -0.415
ENSG00000136709 E035 168.694051 0.0002455688 3.264298e-09 4.398688e-08 2 127768933 127769001 69 - 2.290 2.147 -0.478
ENSG00000136709 E036 288.614035 0.0010470040 4.853335e-13 1.252145e-11 2 127770778 127771004 227 - 2.530 2.365 -0.551
ENSG00000136709 E037 1.887419 0.0076571932 9.209269e-01 9.541154e-01 2 127810749 127811011 263 - 0.466 0.466 -0.003
ENSG00000136709 E038 144.542823 0.0002507667 1.751349e-08 2.064641e-07 2 127811012 127811377 366 - 2.225 2.077 -0.493