ENSG00000136699

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351288 ENSG00000136699 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4 protein_coding protein_coding 102.3764 152.8287 70.56248 8.560545 0.6481729 -1.114832 45.81940 57.314580 39.957721 5.857745 0.2474365 -0.5203186 0.48106667 0.37430000 0.5664000 0.19210000 3.606863e-05 1.439989e-36 FALSE TRUE
ENST00000439886 ENSG00000136699 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4 protein_coding protein_coding 102.3764 152.8287 70.56248 8.560545 0.6481729 -1.114832 11.63891 18.580731 7.725504 1.209719 0.3587702 -1.2650162 0.11085417 0.12186667 0.1094667 -0.01240000 6.513511e-01 1.439989e-36 FALSE TRUE
ENST00000491128 ENSG00000136699 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4 protein_coding retained_intron 102.3764 152.8287 70.56248 8.560545 0.6481729 -1.114832 18.49379 45.527224 1.163054 5.857134 1.1630542 -5.2787048 0.14022917 0.30003333 0.0164000 -0.28363333 1.858718e-02 1.439989e-36 FALSE TRUE
ENST00000680298 ENSG00000136699 HEK293_OSMI2_2hA HEK293_TMG_2hB SMPD4 protein_coding protein_coding 102.3764 152.8287 70.56248 8.560545 0.6481729 -1.114832 2.26014 8.014967 0.000000 1.083770 0.0000000 -9.6483516 0.01541667 0.05196667 0.0000000 -0.05196667 1.439989e-36 1.439989e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136699 E001 0.8814403 0.0140491847 1.134263e-01 2.105207e-01 2 130151392 130151404 13 - 0.001 0.322 9.725
ENSG00000136699 E002 1.6145875 0.0090909353 2.034995e-02 5.221989e-02 2 130151405 130151407 3 - 0.000 0.474 13.040
ENSG00000136699 E003 6.1336378 0.0027065665 3.461568e-05 2.026651e-04 2 130151408 130151408 1 - 0.171 0.916 3.910
ENSG00000136699 E004 31.7316894 0.0037346890 1.839211e-05 1.150627e-04 2 130151409 130151431 23 - 1.176 1.544 1.281
ENSG00000136699 E005 32.3248621 0.0072884585 3.496502e-05 2.044387e-04 2 130151432 130151433 2 - 1.176 1.554 1.315
ENSG00000136699 E006 41.0040926 0.0009737520 2.357034e-04 1.115468e-03 2 130151434 130151437 4 - 1.374 1.633 0.887
ENSG00000136699 E007 354.6548730 0.0066389216 3.046507e-12 6.909513e-11 2 130151438 130151633 196 - 2.225 2.572 1.159
ENSG00000136699 E008 3292.1630969 0.0020445595 4.435290e-14 1.325319e-12 2 130151634 130152745 1112 - 3.336 3.508 0.572
ENSG00000136699 E009 809.9635348 0.0006657223 7.623681e-10 1.155242e-08 2 130152746 130152884 139 - 2.757 2.889 0.439
ENSG00000136699 E010 660.6115827 0.0003320351 5.031731e-08 5.424186e-07 2 130153043 130153109 67 - 2.682 2.795 0.374
ENSG00000136699 E011 647.7805761 0.0001297394 2.069679e-06 1.604708e-05 2 130153110 130153171 62 - 2.689 2.781 0.308
ENSG00000136699 E012 518.9576415 0.0001291803 4.076392e-03 1.335767e-02 2 130153319 130153355 37 - 2.614 2.680 0.220
ENSG00000136699 E013 743.2505264 0.0001131302 4.919534e-04 2.129632e-03 2 130153356 130153450 95 - 2.769 2.837 0.224
ENSG00000136699 E014 1261.2229567 0.0001212168 3.503571e-01 4.945356e-01 2 130153702 130153935 234 - 3.029 3.055 0.086
ENSG00000136699 E015 14.1421104 0.0070768636 5.670980e-02 1.209644e-01 2 130153936 130154093 158 - 1.241 1.065 -0.629
ENSG00000136699 E016 15.3889320 0.0287260872 3.085717e-03 1.051819e-02 2 130154094 130154276 183 - 1.375 1.041 -1.184
ENSG00000136699 E017 615.1845003 0.0007300100 7.165275e-01 8.121672e-01 2 130154277 130154354 78 - 2.731 2.740 0.028
ENSG00000136699 E018 601.1588270 0.0001936603 9.079742e-01 9.455783e-01 2 130154355 130154482 128 - 2.718 2.731 0.042
ENSG00000136699 E019 20.5674744 0.0009145002 5.939040e-03 1.844844e-02 2 130154483 130155095 613 - 1.416 1.214 -0.706
ENSG00000136699 E020 251.9925757 0.0002010332 5.412815e-01 6.722840e-01 2 130155096 130155106 11 - 2.351 2.349 -0.004
ENSG00000136699 E021 618.3146674 0.0001556873 7.770665e-01 8.565016e-01 2 130155107 130155259 153 - 2.723 2.742 0.064
ENSG00000136699 E022 4.1838600 0.0230426248 8.956694e-01 9.373498e-01 2 130156027 130156034 8 - 0.686 0.675 -0.048
ENSG00000136699 E023 287.1818241 0.0001747158 4.452476e-01 5.868100e-01 2 130156035 130156045 11 - 2.381 2.414 0.108
ENSG00000136699 E024 279.5738379 0.0001554442 1.508646e-01 2.628501e-01 2 130156046 130156052 7 - 2.358 2.407 0.163
ENSG00000136699 E025 459.9468955 0.0006814694 3.025588e-02 7.246836e-02 2 130156053 130156135 83 - 2.564 2.628 0.212
ENSG00000136699 E026 21.5840283 0.0252172730 6.670230e-04 2.777824e-03 2 130156136 130156376 241 - 1.522 1.184 -1.178
ENSG00000136699 E027 18.9591043 0.0016431416 2.747475e-04 1.276989e-03 2 130156377 130156584 208 - 1.432 1.152 -0.982
ENSG00000136699 E028 321.7843090 0.0006807862 4.009051e-02 9.119979e-02 2 130156585 130156626 42 - 2.408 2.475 0.224
ENSG00000136699 E029 399.9917897 0.0001359998 2.790859e-02 6.783069e-02 2 130156627 130156675 49 - 2.506 2.565 0.196
ENSG00000136699 E030 69.4984733 0.0003722528 1.229665e-01 2.241931e-01 2 130156676 130156813 138 - 1.836 1.779 -0.192
ENSG00000136699 E031 498.1190033 0.0001888871 3.095895e-01 4.519074e-01 2 130157251 130157360 110 - 2.619 2.653 0.111
ENSG00000136699 E032 329.2281466 0.0003192214 1.617477e-02 4.310878e-02 2 130157361 130157396 36 - 2.495 2.455 -0.133
ENSG00000136699 E033 95.7669413 0.0111255907 2.223691e-02 5.616901e-02 2 130157397 130157953 557 - 2.022 1.893 -0.433
ENSG00000136699 E034 36.9883629 0.0031950785 5.787895e-01 7.037910e-01 2 130158184 130158265 82 - 1.541 1.518 -0.080
ENSG00000136699 E035 27.0067111 0.0027502997 2.405955e-01 3.748672e-01 2 130159513 130159634 122 - 1.447 1.374 -0.254
ENSG00000136699 E036 184.2912145 0.0028920085 2.956089e-13 7.857756e-12 2 130159637 130161090 1454 - 2.383 2.128 -0.853
ENSG00000136699 E037 20.3239703 0.0009988735 1.949341e-04 9.423148e-04 2 130161091 130161185 95 - 1.455 1.178 -0.967
ENSG00000136699 E038 142.7937468 0.0002750274 2.172031e-03 7.756107e-03 2 130161186 130161272 87 - 2.012 2.132 0.402
ENSG00000136699 E039 436.4063438 0.0051551122 1.946797e-02 5.034671e-02 2 130164374 130164445 72 - 2.643 2.569 -0.247
ENSG00000136699 E040 738.3536713 0.0008240764 7.979217e-07 6.766814e-06 2 130167458 130167590 133 - 2.873 2.794 -0.264
ENSG00000136699 E041 2.4681056 0.0061438363 6.874940e-01 7.898285e-01 2 130167591 130167663 73 - 0.533 0.474 -0.285
ENSG00000136699 E042 0.8375349 0.2680185652 6.401056e-01 7.534114e-01 2 130170362 130170453 92 - 0.293 0.221 -0.537
ENSG00000136699 E043 818.9718126 0.0003095927 1.381452e-16 5.841785e-15 2 130172349 130172500 152 - 2.938 2.827 -0.369
ENSG00000136699 E044 550.9746073 0.0001886367 3.413096e-17 1.554702e-15 2 130172625 130172677 53 - 2.777 2.649 -0.428
ENSG00000136699 E045 443.9697259 0.0001598551 2.314979e-14 7.216814e-13 2 130172787 130172833 47 - 2.683 2.556 -0.422
ENSG00000136699 E046 497.2091726 0.0005690805 1.044091e-13 2.959748e-12 2 130172834 130172895 62 - 2.737 2.603 -0.446
ENSG00000136699 E047 452.6735590 0.0008190111 1.383580e-12 3.312042e-11 2 130173279 130173354 76 - 2.701 2.561 -0.468
ENSG00000136699 E048 391.9508768 0.0010492009 3.482208e-07 3.178788e-06 2 130173514 130173604 91 - 2.618 2.509 -0.361
ENSG00000136699 E049 264.9946586 0.0017069849 1.008918e-06 8.360520e-06 2 130173605 130173656 52 - 2.464 2.332 -0.440
ENSG00000136699 E050 383.1442186 0.0044550080 1.044658e-05 6.915246e-05 2 130174914 130175000 87 - 2.634 2.489 -0.483
ENSG00000136699 E051 352.0685322 0.0049747258 2.893823e-05 1.728384e-04 2 130176554 130176637 84 - 2.598 2.452 -0.484
ENSG00000136699 E052 5.2113955 0.0853311028 1.258530e-01 2.283614e-01 2 130181296 130181529 234 - 0.939 0.669 -1.069
ENSG00000136699 E053 343.3990817 0.0081073296 5.028078e-03 1.600905e-02 2 130181530 130181948 419 - 2.564 2.452 -0.373
ENSG00000136699 E054 71.8524677 0.0138299088 1.002083e-01 1.908017e-01 2 130181949 130182750 802 - 1.877 1.779 -0.332