ENSG00000136682

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000490323 ENSG00000136682 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD2 protein_coding retained_intron 44.29482 37.69637 49.61887 1.920218 2.746369 0.3963713 11.683207 17.542366 7.684878 1.6114332 0.9941065 -1.189695 0.2922458 0.46373333 0.1538667 -0.30986667 1.040860e-15 1.04086e-15 FALSE TRUE
MSTRG.19088.1 ENSG00000136682 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD2 protein_coding   44.29482 37.69637 49.61887 1.920218 2.746369 0.3963713 16.156898 9.112552 21.387831 0.8794095 1.1955683 1.229955 0.3337292 0.24420000 0.4312000 0.18700000 1.053506e-03 1.04086e-15 TRUE TRUE
MSTRG.19088.3 ENSG00000136682 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD2 protein_coding   44.29482 37.69637 49.61887 1.920218 2.746369 0.3963713 5.805128 3.459573 6.673849 0.6468909 0.6391717 0.945921 0.1247792 0.09243333 0.1339000 0.04146667 3.423381e-01 1.04086e-15 TRUE TRUE
MSTRG.19088.5 ENSG00000136682 HEK293_OSMI2_2hA HEK293_TMG_2hB CBWD2 protein_coding   44.29482 37.69637 49.61887 1.920218 2.746369 0.3963713 8.282465 5.216512 11.089548 1.4621672 0.8304078 1.086581 0.1943917 0.13566667 0.2242667 0.08860000 1.733360e-01 1.04086e-15 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136682 E001 0.4545463 0.6364783440 0.4672359793 0.606750850 2 113437691 113437762 72 + 0.244 0.000 -9.858
ENSG00000136682 E002 2.8997375 0.0681728967 0.6048660040 0.725296224 2 113437763 113437790 28 + 0.543 0.642 0.442
ENSG00000136682 E003 19.6269679 0.0765980767 0.6334708847 0.748172782 2 113437791 113437816 26 + 1.321 1.276 -0.157
ENSG00000136682 E004 34.6173886 0.0092277935 0.8288805547 0.892493830 2 113437817 113437821 5 + 1.549 1.535 -0.048
ENSG00000136682 E005 78.7895974 0.0022288966 0.3122644881 0.454802845 2 113437822 113437838 17 + 1.915 1.870 -0.152
ENSG00000136682 E006 126.2450613 0.0021214880 0.6694408197 0.776253711 2 113437839 113437878 40 + 2.106 2.090 -0.054
ENSG00000136682 E007 198.1667479 0.0002745831 0.6287952051 0.744279142 2 113437879 113438022 144 + 2.288 2.300 0.042
ENSG00000136682 E008 7.4320411 0.0757978646 0.5279644996 0.660895789 2 113439020 113439117 98 + 0.966 0.861 -0.397
ENSG00000136682 E009 101.1399169 0.0020523672 0.9794673945 0.991208258 2 113441351 113441437 87 + 2.003 2.005 0.007
ENSG00000136682 E010 0.2955422 0.0294772995 0.6989189727   2 113441438 113441729 292 + 0.097 0.154 0.771
ENSG00000136682 E011 0.0000000       2 113443762 113443766 5 +      
ENSG00000136682 E012 138.8609192 0.0042700140 0.8026145288 0.874269288 2 113443767 113443863 97 + 2.136 2.148 0.040
ENSG00000136682 E013 7.5074739 0.0024431301 0.0124622108 0.034646676 2 113443864 113444375 512 + 0.777 1.066 1.096
ENSG00000136682 E014 197.3626099 0.0006610559 0.1449097866 0.254724927 2 113444964 113445055 92 + 2.309 2.270 -0.129
ENSG00000136682 E015 1.4821929 0.0197795862 0.6439504285 0.756381338 2 113445056 113445540 485 + 0.438 0.356 -0.454
ENSG00000136682 E016 188.0344830 0.0002055032 0.1013869110 0.192580949 2 113453139 113453198 60 + 2.289 2.247 -0.139
ENSG00000136682 E017 148.2158975 0.0005980859 0.4732197998 0.612218298 2 113454741 113454778 38 + 2.177 2.155 -0.072
ENSG00000136682 E018 7.6171633 0.0308635954 0.0001477497 0.000737405 2 113457065 113457209 145 + 1.096 0.493 -2.441
ENSG00000136682 E019 190.0618640 0.0002791717 0.5466432085 0.676784169 2 113460673 113460719 47 + 2.282 2.267 -0.051
ENSG00000136682 E020 194.6820258 0.0003774966 0.9728269805 0.987034274 2 113462408 113462494 87 + 2.285 2.286 0.002
ENSG00000136682 E021 0.1451727 0.0434018101 0.8127496760   2 113462495 113462834 340 + 0.097 0.000 -10.539
ENSG00000136682 E022 97.5236742 0.0019989701 0.8209847798 0.887163166 2 113465129 113465173 45 + 1.984 1.991 0.025
ENSG00000136682 E023 19.3197005 0.0010178675 0.1649117287 0.281590152 2 113468585 113471032 2448 + 1.346 1.235 -0.388
ENSG00000136682 E024 63.3604282 0.0074814720 0.1093616366 0.204622512 2 113471033 113471089 57 + 1.762 1.855 0.313
ENSG00000136682 E025 1.9551705 0.0075216756 0.0404362539 0.091823115 2 113481518 113482176 659 + 0.300 0.643 1.772
ENSG00000136682 E026 72.0404225 0.0005470412 0.0056635463 0.017722881 2 113482177 113482228 52 + 1.808 1.924 0.391
ENSG00000136682 E027 37.9311815 0.0020979167 0.0423011346 0.095275621 2 113493757 113493825 69 + 1.536 1.658 0.417
ENSG00000136682 E028 12.3473181 0.0478994391 0.1006725619 0.191489019 2 113493929 113493994 66 + 1.018 1.227 0.750
ENSG00000136682 E029 0.8459408 0.0209861147 0.3044268581 0.446435383 2 113493995 113495119 1125 + 0.175 0.357 1.359
ENSG00000136682 E030 16.6046900 0.0047888576 0.2215159529 0.352219401 2 113495120 113495249 130 + 1.188 1.295 0.377
ENSG00000136682 E031 0.5997190 0.1293826976 0.1432044296 0.252382920 2 113495250 113495636 387 + 0.301 0.000 -12.521
ENSG00000136682 E032 12.1723651 0.0126367789 0.4685625812 0.607973476 2 113495637 113495798 162 + 1.078 1.153 0.271
ENSG00000136682 E033 4.1352080 0.0461074487 0.0054844052 0.017246108 2 113495799 113496204 406 + 0.438 0.898 1.986
ENSG00000136682 E034 1.6671050 0.0085633603 0.8417764036 0.901323196 2 113497398 113497582 185 + 0.397 0.432 0.189