ENSG00000136636

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259154 ENSG00000136636 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD3 protein_coding protein_coding 20.34464 11.40973 28.98 0.994904 0.5239364 1.344026 7.954378 2.234946 15.8439410 0.2705057 0.2081028 2.82008898 0.35679167 0.2009000 0.547100000 0.346200000 2.299213e-07 2.299213e-07 FALSE TRUE
ENST00000448333 ENSG00000136636 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD3 protein_coding protein_coding 20.34464 11.40973 28.98 0.994904 0.5239364 1.344026 1.534340 1.702185 1.6670902 0.2684045 0.5040870 -0.02987845 0.09862917 0.1485000 0.056966667 -0.091533333 2.774382e-02 2.299213e-07 FALSE TRUE
ENST00000465650 ENSG00000136636 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD3 protein_coding processed_transcript 20.34464 11.40973 28.98 0.994904 0.5239364 1.344026 1.201254 2.853908 0.1492676 0.7085860 0.1492676 -4.16845997 0.10535417 0.2430000 0.005266667 -0.237733333 1.466431e-03 2.299213e-07 FALSE TRUE
MSTRG.3054.5 ENSG00000136636 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD3 protein_coding   20.34464 11.40973 28.98 0.994904 0.5239364 1.344026 5.013940 2.219664 6.0551810 0.1815588 1.3831167 1.44372421 0.24137917 0.1982333 0.208200000 0.009966667 1.000000e+00 2.299213e-07 FALSE TRUE
MSTRG.3054.6 ENSG00000136636 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD3 protein_coding   20.34464 11.40973 28.98 0.994904 0.5239364 1.344026 3.534372 1.849400 3.6391400 0.2658890 1.2301256 0.97271947 0.13904583 0.1624667 0.126500000 -0.035966667 6.938736e-01 2.299213e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136636 E001 0.1515154 0.0429773330 1.000000e+00   1 215567082 215567141 60 + 0.069 0.000 -8.709
ENSG00000136636 E002 5.3595230 0.0029482520 1.341493e-02 3.687971e-02 1 215567304 215567310 7 + 0.827 0.453 -1.637
ENSG00000136636 E003 16.3902291 0.0019108480 1.638287e-03 6.084225e-03 1 215567311 215567366 56 + 1.241 0.952 -1.047
ENSG00000136636 E004 27.0653379 0.0007239863 8.671142e-05 4.596569e-04 1 215567367 215567521 155 + 1.444 1.160 -0.993
ENSG00000136636 E005 18.6638097 0.0009791202 3.906608e-04 1.738645e-03 1 215567522 215567620 99 + 1.294 0.981 -1.124
ENSG00000136636 E006 43.3805200 0.0004972954 6.320345e-06 4.397732e-05 1 215567621 215567768 148 + 1.637 1.385 -0.865
ENSG00000136636 E007 53.9037910 0.0005079676 3.268630e-04 1.488110e-03 1 215573786 215573839 54 + 1.712 1.555 -0.533
ENSG00000136636 E008 60.2998163 0.0056014024 1.785129e-01 2.992874e-01 1 215574073 215574118 46 + 1.732 1.701 -0.103
ENSG00000136636 E009 79.8704050 0.0003626950 2.143200e-01 3.436387e-01 1 215575901 215575974 74 + 1.847 1.846 -0.004
ENSG00000136636 E010 84.5693190 0.0003640284 7.201512e-01 8.148023e-01 1 215577670 215577728 59 + 1.860 1.900 0.133
ENSG00000136636 E011 83.9569662 0.0004956762 7.385506e-01 8.284064e-01 1 215578001 215578081 81 + 1.859 1.900 0.137
ENSG00000136636 E012 141.7182870 0.0002612482 1.984934e-01 3.243149e-01 1 215579000 215579137 138 + 2.068 2.166 0.328
ENSG00000136636 E013 128.9190779 0.0007612374 8.907443e-01 9.342225e-01 1 215579909 215579999 91 + 2.041 2.102 0.204
ENSG00000136636 E014 11.6820384 0.0191423461 4.779914e-06 3.418940e-05 1 215580972 215581179 208 + 0.826 1.402 2.087
ENSG00000136636 E015 191.7000576 0.0002256487 8.073829e-04 3.284861e-03 1 215586495 215586685 191 + 2.237 2.193 -0.147
ENSG00000136636 E016 139.7638708 0.0008097326 2.444380e-02 6.073904e-02 1 215595356 215595471 116 + 2.096 2.069 -0.089
ENSG00000136636 E017 89.3775479 0.0027544229 3.609236e-01 5.052978e-01 1 215601867 215601954 88 + 1.895 1.906 0.037
ENSG00000136636 E018 98.8378896 0.0028573553 2.548007e-01 3.915799e-01 1 215602085 215602169 85 + 1.939 1.941 0.006
ENSG00000136636 E019 86.2814308 0.0003444072 5.832842e-01 7.074221e-01 1 215602170 215602201 32 + 1.874 1.906 0.107
ENSG00000136636 E020 170.6299611 0.0002941499 4.835700e-03 1.547429e-02 1 215604132 215604302 171 + 2.185 2.152 -0.112
ENSG00000136636 E021 157.4743274 0.0002829438 8.650514e-03 2.540954e-02 1 215608017 215608145 129 + 2.147 2.117 -0.103
ENSG00000136636 E022 91.8249773 0.0003590521 9.850672e-02 1.882171e-01 1 215608146 215608172 27 + 1.912 1.896 -0.052
ENSG00000136636 E023 140.0583540 0.0059831511 2.127354e-02 5.416145e-02 1 215611825 215611921 97 + 2.105 2.039 -0.220
ENSG00000136636 E024 2.5399028 0.1953653880 7.468310e-01 8.344927e-01 1 215618088 215618154 67 + 0.487 0.598 0.516
ENSG00000136636 E025 3.2580392 0.0166514862 9.350808e-01 9.631339e-01 1 215618245 215618704 460 + 0.556 0.610 0.243
ENSG00000136636 E026 2.2763889 0.2258557058 9.804644e-01 9.917660e-01 1 215618705 215618885 181 + 0.465 0.461 -0.018
ENSG00000136636 E027 173.5841979 0.0042897752 9.839380e-03 2.836942e-02 1 215618886 215619070 185 + 2.197 2.135 -0.206
ENSG00000136636 E028 0.4502799 0.0314139361 4.560624e-01 5.965341e-01 1 215619071 215619152 82 + 0.182 0.000 -10.284
ENSG00000136636 E029 61.5138793 0.0027226345 2.732267e-02 6.665290e-02 1 215619153 215619158 6 + 1.756 1.682 -0.252
ENSG00000136636 E030 165.9688648 0.0038281969 1.555201e-02 4.174032e-02 1 215619159 215619291 133 + 2.174 2.122 -0.173
ENSG00000136636 E031 831.6631828 0.0058813562 3.072385e-10 4.991032e-09 1 215620057 215621807 1751 + 2.784 3.029 0.815