ENSG00000136628

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366923 ENSG00000136628 HEK293_OSMI2_2hA HEK293_TMG_2hB EPRS1 protein_coding protein_coding 84.26709 31.55161 137.5552 3.066184 5.85109 2.123873 75.917643 24.494425 124.107009 1.164615 3.5804264 2.340587 0.88673750 0.7842333 0.9034 0.1191667 5.104014e-02 7.29848e-14 FALSE TRUE
ENST00000464052 ENSG00000136628 HEK293_OSMI2_2hA HEK293_TMG_2hB EPRS1 protein_coding retained_intron 84.26709 31.55161 137.5552 3.066184 5.85109 2.123873 5.258551 0.000000 11.290995 0.000000 2.7577073 10.142234 0.03654167 0.0000000 0.0808 0.0808000 7.298480e-14 7.29848e-14 FALSE FALSE
ENST00000468487 ENSG00000136628 HEK293_OSMI2_2hA HEK293_TMG_2hB EPRS1 protein_coding processed_transcript 84.26709 31.55161 137.5552 3.066184 5.85109 2.123873 2.748543 6.976599 1.887534 2.174193 0.3740155 -1.880464 0.07327500 0.2131000 0.0137 -0.1994000 1.958975e-12 7.29848e-14   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136628 E001 3.7253127 1.707740e-01 2.032415e-04 9.777173e-04 1 219968600 219968602 3 - 0.247 1.112 3.963
ENSG00000136628 E002 178.8524622 1.249339e-02 1.851716e-14 5.864295e-13 1 219968603 219968688 86 - 2.004 2.508 1.683
ENSG00000136628 E003 711.5958820 6.461231e-03 2.035028e-23 1.887077e-21 1 219968689 219968956 268 - 2.629 3.069 1.463
ENSG00000136628 E004 582.3719050 1.019306e-02 1.156655e-09 1.694046e-08 1 219969058 219969122 65 - 2.579 2.926 1.154
ENSG00000136628 E005 7.9137415 2.727121e-02 5.683931e-02 1.211852e-01 1 219969123 219969247 125 - 0.804 1.099 1.107
ENSG00000136628 E006 614.5037480 6.820252e-03 1.263563e-12 3.050569e-11 1 219972069 219972147 79 - 2.607 2.942 1.113
ENSG00000136628 E007 961.0773779 2.271977e-03 7.796603e-25 8.420998e-23 1 219973238 219973398 161 - 2.817 3.108 0.968
ENSG00000136628 E008 998.1764704 1.961480e-03 2.267110e-19 1.352747e-17 1 219978546 219978719 174 - 2.849 3.093 0.814
ENSG00000136628 E009 957.0352828 1.823888e-03 6.729964e-12 1.441786e-10 1 219979418 219979615 198 - 2.847 3.039 0.638
ENSG00000136628 E010 664.5232855 8.742397e-04 1.586346e-11 3.195412e-10 1 219980085 219980240 156 - 2.695 2.864 0.562
ENSG00000136628 E011 499.9107131 1.136782e-03 3.909882e-06 2.849183e-05 1 219980756 219980857 102 - 2.580 2.721 0.468
ENSG00000136628 E012 414.8472361 1.668431e-04 1.066263e-06 8.795629e-06 1 219981378 219981457 80 - 2.502 2.632 0.434
ENSG00000136628 E013 0.9482522 1.329681e-01 4.506617e-01 5.917377e-01 1 219982510 219982771 262 - 0.208 0.377 1.172
ENSG00000136628 E014 414.0720521 7.004626e-04 4.298774e-02 9.652251e-02 1 219982772 219982844 73 - 2.515 2.592 0.257
ENSG00000136628 E015 679.2555979 9.314302e-05 1.887351e-03 6.875094e-03 1 219983189 219983398 210 - 2.729 2.808 0.264
ENSG00000136628 E016 348.8373859 1.530946e-04 2.247995e-04 1.069556e-03 1 219984206 219984257 52 - 2.432 2.544 0.373
ENSG00000136628 E017 1.1362862 1.206847e-02 1.567092e-01 2.707112e-01 1 219984258 219984258 1 - 0.208 0.487 1.751
ENSG00000136628 E018 524.1826552 2.281539e-03 6.336277e-01 7.482974e-01 1 219987142 219987295 154 - 2.626 2.664 0.128
ENSG00000136628 E019 469.9593733 3.202923e-03 6.761107e-01 7.811820e-01 1 219987296 219987404 109 - 2.585 2.592 0.025
ENSG00000136628 E020 683.6892974 4.693976e-03 2.962318e-01 4.374315e-01 1 219988590 219988823 234 - 2.752 2.736 -0.054
ENSG00000136628 E021 551.3992310 6.482231e-03 5.567404e-01 6.853200e-01 1 219996983 219997175 193 - 2.656 2.654 -0.005
ENSG00000136628 E022 591.0143236 1.245538e-04 4.153932e-05 2.384986e-04 1 219997176 219997342 167 - 2.697 2.647 -0.166
ENSG00000136628 E023 444.7117141 1.254015e-04 3.316852e-11 6.340743e-10 1 220001138 220001200 63 - 2.586 2.465 -0.403
ENSG00000136628 E024 412.4792058 1.317049e-04 6.468250e-18 3.242632e-16 1 220001201 220001255 55 - 2.563 2.384 -0.595
ENSG00000136628 E025 551.5197008 1.095803e-03 3.133606e-09 4.236137e-08 1 220005248 220005360 113 - 2.679 2.554 -0.419
ENSG00000136628 E026 747.7939886 3.917674e-03 7.737321e-07 6.584074e-06 1 220006106 220006313 208 - 2.815 2.666 -0.497
ENSG00000136628 E027 635.4631597 3.538019e-03 1.683392e-07 1.637185e-06 1 220007202 220007338 137 - 2.746 2.588 -0.526
ENSG00000136628 E028 1.3296319 1.202258e-01 2.679854e-01 4.063732e-01 1 220007339 220007365 27 - 0.248 0.490 1.442
ENSG00000136628 E029 481.1697787 1.472664e-03 2.262670e-13 6.120162e-12 1 220010946 220011056 111 - 2.630 2.442 -0.628
ENSG00000136628 E030 0.1472490 4.324419e-02 1.000000e+00   1 220018126 220018146 21 - 0.062 0.001 -6.135
ENSG00000136628 E031 302.8793829 1.457311e-04 7.412334e-08 7.720295e-07 1 220018449 220018508 60 - 2.419 2.301 -0.392
ENSG00000136628 E032 388.5137867 4.632155e-03 6.473689e-04 2.706733e-03 1 220018995 220019079 85 - 2.525 2.409 -0.389
ENSG00000136628 E033 646.8516772 3.714723e-03 2.842648e-10 4.644913e-09 1 220019988 220020221 234 - 2.760 2.559 -0.669
ENSG00000136628 E034 532.1341273 2.475991e-03 1.073314e-14 3.512456e-13 1 220022347 220022518 172 - 2.679 2.450 -0.764
ENSG00000136628 E035 548.5369110 7.935293e-03 2.438283e-08 2.794636e-07 1 220024264 220024456 193 - 2.695 2.444 -0.836
ENSG00000136628 E036 491.2467593 1.563905e-03 2.570897e-32 5.084017e-30 1 220025132 220025258 127 - 2.659 2.316 -1.142
ENSG00000136628 E037 510.2053883 6.174835e-03 7.516000e-15 2.521933e-13 1 220030386 220030480 95 - 2.674 2.341 -1.108
ENSG00000136628 E038 540.7907054 4.495807e-03 5.029548e-19 2.868250e-17 1 220032387 220032526 140 - 2.700 2.363 -1.123
ENSG00000136628 E039 539.2213536 5.459302e-03 3.216235e-13 8.503924e-12 1 220033502 220033658 157 - 2.693 2.405 -0.959
ENSG00000136628 E040 390.0678166 9.950181e-03 4.261755e-10 6.759118e-09 1 220034914 220035013 100 - 2.557 2.227 -1.101
ENSG00000136628 E041 393.6692080 1.394450e-02 1.956203e-09 2.744146e-08 1 220040185 220040269 85 - 2.565 2.202 -1.212
ENSG00000136628 E042 361.0499952 7.878834e-03 2.764603e-15 9.881995e-14 1 220046343 220046615 273 - 2.531 2.134 -1.327