ENSG00000136603

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259119 ENSG00000136603 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIL protein_coding protein_coding 4.146598 1.018816 8.426323 0.1207385 0.4321847 3.035629 1.15662773 0.13062522 3.33436553 0.10481161 0.31027634 4.5718053 0.24100000 0.13443333 0.401000000 0.266566667 0.2267644871 0.0001162617 FALSE TRUE
ENST00000426052 ENSG00000136603 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIL protein_coding protein_coding 4.146598 1.018816 8.426323 0.1207385 0.4321847 3.035629 0.02973158 0.06208478 0.05990596 0.06208478 0.05990596 -0.0442792 0.02536667 0.07583333 0.006533333 -0.069300000 0.7104317324 0.0001162617 FALSE TRUE
ENST00000458537 ENSG00000136603 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIL protein_coding protein_coding 4.146598 1.018816 8.426323 0.1207385 0.4321847 3.035629 0.50740841 0.01691928 0.23517786 0.01691928 0.23517786 3.1871171 0.13185833 0.02066667 0.025600000 0.004933333 0.8442832314 0.0001162617 FALSE TRUE
ENST00000465590 ENSG00000136603 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIL protein_coding processed_transcript 4.146598 1.018816 8.426323 0.1207385 0.4321847 3.035629 0.61743866 0.13728945 1.50426742 0.13728945 0.17851246 3.3618940 0.10477500 0.11106667 0.180066667 0.069000000 0.5198300185 0.0001162617   FALSE
ENST00000470571 ENSG00000136603 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIL protein_coding nonsense_mediated_decay 4.146598 1.018816 8.426323 0.1207385 0.4321847 3.035629 0.72578010 0.11082960 0.96902796 0.08487142 0.01754978 3.0183761 0.11115417 0.09313333 0.115366667 0.022233333 0.8456611111 0.0001162617 FALSE FALSE
ENST00000476188 ENSG00000136603 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIL protein_coding protein_coding 4.146598 1.018816 8.426323 0.1207385 0.4321847 3.035629 0.34219543 0.00000000 0.78957427 0.00000000 0.41858402 6.3211601 0.04260417 0.00000000 0.089133333 0.089133333 0.5266119719 0.0001162617 FALSE TRUE
ENST00000490989 ENSG00000136603 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIL protein_coding processed_transcript 4.146598 1.018816 8.426323 0.1207385 0.4321847 3.035629 0.32445613 0.06410009 0.72149480 0.06410009 0.04837544 3.3033004 0.10069583 0.06400000 0.085633333 0.021633333 0.7353145063 0.0001162617   FALSE
MSTRG.24055.1 ENSG00000136603 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIL protein_coding   4.146598 1.018816 8.426323 0.1207385 0.4321847 3.035629 0.16332675 0.14309149 0.25986637 0.14309149 0.13746374 0.8178511 0.06546250 0.11576667 0.029866667 -0.085900000 1.0000000000 0.0001162617 FALSE TRUE
MSTRG.24055.3 ENSG00000136603 HEK293_OSMI2_2hA HEK293_TMG_2hB SKIL protein_coding   4.146598 1.018816 8.426323 0.1207385 0.4321847 3.035629 0.08887188 0.33023245 0.01374645 0.11877056 0.01374645 -3.8407371 0.10305000 0.36150000 0.001800000 -0.359700000 0.0001162617 0.0001162617 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136603 E001 2.7647963 0.0055950325 1.870139e-02 4.867900e-02 3 170357658 170357677 20 + 0.374 0.786 1.901
ENSG00000136603 E002 2.5486365 0.0058982538 1.911269e-01 3.151453e-01 3 170357678 170357684 7 + 0.397 0.644 1.190
ENSG00000136603 E003 4.6220036 0.0036387439 5.476726e-01 6.776857e-01 3 170357685 170357714 30 + 0.614 0.721 0.453
ENSG00000136603 E004 6.8018322 0.0057990125 3.209026e-01 4.640695e-01 3 170357715 170357733 19 + 0.739 0.893 0.605
ENSG00000136603 E005 7.6176117 0.0070622562 3.086373e-01 4.509133e-01 3 170357734 170357763 30 + 0.785 0.937 0.585
ENSG00000136603 E006 0.7427016 0.0156599915 6.010756e-01 7.222262e-01 3 170357764 170357856 93 + 0.210 0.000 -9.980
ENSG00000136603 E007 4.6743427 0.0097265509 3.237188e-01 4.670457e-01 3 170358509 170358645 137 + 0.614 0.785 0.712
ENSG00000136603 E008 1.4165150 0.0277528199 1.228846e-01 2.240727e-01 3 170359623 170359698 76 + 0.242 0.550 1.772
ENSG00000136603 E009 17.4496966 0.0014548192 1.502649e-01 2.620424e-01 3 170359699 170359774 76 + 1.104 1.256 0.541
ENSG00000136603 E010 22.8607180 0.0008772428 9.264219e-01 9.576673e-01 3 170359775 170359876 102 + 1.241 1.235 -0.022
ENSG00000136603 E011 39.9012001 0.0017111843 1.081064e-03 4.239114e-03 3 170359877 170360320 444 + 1.507 1.212 -1.023
ENSG00000136603 E012 16.4405686 0.0152148593 3.549478e-02 8.260705e-02 3 170360321 170360367 47 + 1.144 0.841 -1.126
ENSG00000136603 E013 76.0200344 0.0003298427 7.690184e-08 7.984229e-07 3 170360368 170361211 844 + 1.782 1.424 -1.220
ENSG00000136603 E014 19.6634481 0.0009240859 1.134399e-01 2.105418e-01 3 170361212 170361340 129 + 1.199 1.016 -0.661
ENSG00000136603 E015 17.9694015 0.0010001971 1.101659e-02 3.120045e-02 3 170361341 170361429 89 + 1.178 0.843 -1.239
ENSG00000136603 E016 14.8150925 0.0018828449 2.706036e-02 6.611412e-02 3 170381244 170381275 32 + 1.099 0.786 -1.180
ENSG00000136603 E017 18.4960571 0.0009790429 7.326906e-04 3.016998e-03 3 170381276 170381341 66 + 1.199 0.721 -1.799
ENSG00000136603 E018 25.5016466 0.0007820964 3.991832e-06 2.905042e-05 3 170384533 170384627 95 + 1.336 0.721 -2.279
ENSG00000136603 E019 27.7826261 0.0021433788 6.046713e-03 1.873467e-02 3 170384628 170384765 138 + 1.348 1.050 -1.057
ENSG00000136603 E020 0.2924217 0.0274897595 1.000000e+00   3 170384766 170385049 284 + 0.096 0.000 -8.668
ENSG00000136603 E021 43.5938591 0.0645156221 3.193716e-01 4.624521e-01 3 170390223 170390464 242 + 1.520 1.398 -0.421
ENSG00000136603 E022 40.8787873 0.0008401931 8.375066e-01 8.984118e-01 3 170391036 170391260 225 + 1.477 1.464 -0.045
ENSG00000136603 E023 229.9378529 0.0008111978 2.445642e-22 2.024113e-20 3 170392259 170396835 4577 + 2.173 2.410 0.791