ENSG00000136560

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392749 ENSG00000136560 HEK293_OSMI2_2hA HEK293_TMG_2hB TANK protein_coding protein_coding 14.17386 6.378191 22.71321 0.1228576 1.000801 1.830687 5.6125863 2.3981293 8.37679987 0.21682829 0.43077237 1.8002076 0.37116250 0.37523333 0.368666667 -0.006566667 9.395125e-01 3.735189e-19 FALSE TRUE
ENST00000403609 ENSG00000136560 HEK293_OSMI2_2hA HEK293_TMG_2hB TANK protein_coding protein_coding 14.17386 6.378191 22.71321 0.1228576 1.000801 1.830687 1.0366310 0.9102851 1.68264528 0.11002713 0.46100954 0.8791269 0.08754583 0.14220000 0.072600000 -0.069600000 1.964250e-01 3.735189e-19 FALSE TRUE
ENST00000440506 ENSG00000136560 HEK293_OSMI2_2hA HEK293_TMG_2hB TANK protein_coding protein_coding 14.17386 6.378191 22.71321 0.1228576 1.000801 1.830687 2.2521095 0.0000000 4.89059004 0.00000000 0.60852814 8.9368117 0.10025833 0.00000000 0.214500000 0.214500000 3.735189e-19 3.735189e-19 FALSE FALSE
ENST00000456358 ENSG00000136560 HEK293_OSMI2_2hA HEK293_TMG_2hB TANK protein_coding protein_coding 14.17386 6.378191 22.71321 0.1228576 1.000801 1.830687 0.7406108 0.0000000 1.55666147 0.00000000 0.52232408 7.2915497 0.03827083 0.00000000 0.069400000 0.069400000 2.571987e-04 3.735189e-19 FALSE FALSE
ENST00000461338 ENSG00000136560 HEK293_OSMI2_2hA HEK293_TMG_2hB TANK protein_coding processed_transcript 14.17386 6.378191 22.71321 0.1228576 1.000801 1.830687 0.5435236 0.5486873 0.85635842 0.12481605 0.17975890 0.6329229 0.05253750 0.08580000 0.037766667 -0.048033333 9.952440e-02 3.735189e-19   FALSE
ENST00000477952 ENSG00000136560 HEK293_OSMI2_2hA HEK293_TMG_2hB TANK protein_coding retained_intron 14.17386 6.378191 22.71321 0.1228576 1.000801 1.830687 0.7917556 0.7755181 0.50498581 0.43209461 0.27318955 -0.6091117 0.09337917 0.12353333 0.023400000 -0.100133333 7.150465e-01 3.735189e-19   FALSE
ENST00000483622 ENSG00000136560 HEK293_OSMI2_2hA HEK293_TMG_2hB TANK protein_coding retained_intron 14.17386 6.378191 22.71321 0.1228576 1.000801 1.830687 0.6402614 0.4700889 0.85686610 0.29498465 0.25622639 0.8525076 0.05926667 0.07346667 0.036866667 -0.036600000 8.458759e-01 3.735189e-19   FALSE
MSTRG.19409.4 ENSG00000136560 HEK293_OSMI2_2hA HEK293_TMG_2hB TANK protein_coding   14.17386 6.378191 22.71321 0.1228576 1.000801 1.830687 0.1445028 0.3928783 0.05331157 0.04903841 0.05331157 -2.6698030 0.02718333 0.06196667 0.002533333 -0.059433333 1.142191e-03 3.735189e-19 FALSE TRUE
MSTRG.19409.6 ENSG00000136560 HEK293_OSMI2_2hA HEK293_TMG_2hB TANK protein_coding   14.17386 6.378191 22.71321 0.1228576 1.000801 1.830687 0.9789057 0.5634688 2.29076752 0.30398253 0.49209024 2.0043283 0.07183750 0.08776667 0.102900000 0.015133333 8.226506e-01 3.735189e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136560 E001 0.0000000       2 161136908 161136926 19 +      
ENSG00000136560 E002 0.0000000       2 161136927 161136965 39 +      
ENSG00000136560 E003 0.0000000       2 161136966 161137063 98 +      
ENSG00000136560 E004 0.0000000       2 161160299 161160308 10 +      
ENSG00000136560 E005 1.0478088 0.1438748396 1.688399e-01 2.866739e-01 2 161160309 161160343 35 + 0.343 0.000 -10.711
ENSG00000136560 E006 1.0478088 0.1438748396 1.688399e-01 2.866739e-01 2 161160344 161160348 5 + 0.343 0.000 -12.605
ENSG00000136560 E007 4.5594487 0.0091124340 8.933273e-02 1.741129e-01 2 161160349 161160405 57 + 0.750 0.456 -1.314
ENSG00000136560 E008 5.5956162 0.0042226624 7.674398e-02 1.542787e-01 2 161160406 161160426 21 + 0.823 0.541 -1.189
ENSG00000136560 E009 5.7460995 0.0029170951 1.617786e-01 2.774421e-01 2 161160427 161160427 1 + 0.823 0.612 -0.867
ENSG00000136560 E010 6.9190060 0.0023902482 2.737656e-01 4.128583e-01 2 161160428 161160431 4 + 0.875 0.727 -0.585
ENSG00000136560 E011 6.1042983 0.0026150083 2.608052e-01 3.983893e-01 2 161160432 161160436 5 + 0.834 0.673 -0.647
ENSG00000136560 E012 32.1012765 0.0041103312 7.686031e-01 8.504486e-01 2 161160437 161160456 20 + 1.463 1.451 -0.042
ENSG00000136560 E013 49.3201693 0.0008853189 7.909235e-01 8.662903e-01 2 161160457 161160484 28 + 1.633 1.659 0.089
ENSG00000136560 E014 36.0301173 0.0005946144 3.317947e-01 4.754317e-01 2 161160485 161160486 2 + 1.486 1.560 0.254
ENSG00000136560 E015 2.5809033 0.0066041145 8.927892e-01 9.354761e-01 2 161160726 161160822 97 + 0.508 0.541 0.154
ENSG00000136560 E016 7.0621089 0.0139080877 1.344765e-01 2.403798e-01 2 161160949 161161104 156 + 0.775 0.988 0.813
ENSG00000136560 E017 29.9167870 0.0164350252 2.555950e-02 6.303843e-02 2 161161285 161161412 128 + 1.363 1.572 0.720
ENSG00000136560 E018 6.1625166 0.0028787913 1.215721e-04 6.210454e-04 2 161161413 161161666 254 + 0.611 1.106 1.934
ENSG00000136560 E019 2.8129576 0.0055185511 5.787533e-01 7.037828e-01 2 161161813 161161907 95 + 0.508 0.612 0.477
ENSG00000136560 E020 3.5397646 0.0045196439 6.560310e-01 7.657946e-01 2 161162533 161163113 581 + 0.592 0.673 0.353
ENSG00000136560 E021 10.4383269 0.0020496911 5.479598e-03 1.723406e-02 2 161163114 161163518 405 + 0.913 1.216 1.106
ENSG00000136560 E022 0.1472490 0.0433691319 1.000000e+00   2 161179483 161179613 131 + 0.069 0.000 -10.316
ENSG00000136560 E023 44.9308965 0.0004834978 2.905218e-01 4.313453e-01 2 161179614 161179620 7 + 1.613 1.560 -0.182
ENSG00000136560 E024 53.0358514 0.0004155016 8.008090e-02 1.596805e-01 2 161179621 161179652 32 + 1.691 1.602 -0.301
ENSG00000136560 E025 78.2137698 0.0003800152 3.915348e-03 1.290563e-02 2 161179653 161179761 109 + 1.865 1.739 -0.426
ENSG00000136560 E026 0.6568746 0.0347466778 2.734296e-02 6.669381e-02 2 161179762 161180085 324 + 0.069 0.456 3.439
ENSG00000136560 E027 0.1451727 0.0437167390 1.000000e+00   2 161197337 161197528 192 + 0.069 0.000 -10.314
ENSG00000136560 E028 0.9286724 0.0150484091 7.523148e-01 8.385619e-01 2 161202863 161202979 117 + 0.268 0.209 -0.466
ENSG00000136560 E029 0.7406253 0.0155566199 2.438199e-01 3.786765e-01 2 161203484 161203486 3 + 0.268 0.000 -12.649
ENSG00000136560 E030 80.1988092 0.0019300101 1.035277e-02 2.963362e-02 2 161203487 161203595 109 + 1.876 1.758 -0.397
ENSG00000136560 E031 69.2315304 0.0004942291 2.544017e-01 3.910872e-01 2 161204675 161204793 119 + 1.794 1.749 -0.152
ENSG00000136560 E032 8.0773591 0.0063257019 2.528439e-03 8.848018e-03 2 161204794 161204979 186 + 0.775 1.146 1.389
ENSG00000136560 E033 0.2966881 0.0272738961 9.227110e-01   2 161216389 161216442 54 + 0.128 0.000 -11.369
ENSG00000136560 E034 0.2924217 0.0273411446 9.233599e-01   2 161219724 161219842 119 + 0.128 0.000 -11.368
ENSG00000136560 E035 0.1472490 0.0433691319 1.000000e+00   2 161223400 161223818 419 + 0.069 0.000 -10.316
ENSG00000136560 E036 26.2788595 0.0007898545 2.152024e-01 3.446684e-01 2 161223915 161223919 5 + 1.394 1.305 -0.309
ENSG00000136560 E037 42.5447329 0.0008928429 6.754020e-04 2.809188e-03 2 161223920 161223991 72 + 1.622 1.401 -0.759
ENSG00000136560 E038 56.0175295 0.0030038961 6.151421e-05 3.389374e-04 2 161224631 161224746 116 + 1.745 1.496 -0.847
ENSG00000136560 E039 74.0756338 0.0003340556 1.070657e-01 2.012082e-01 2 161230971 161231185 215 + 1.829 1.763 -0.221
ENSG00000136560 E040 143.0178854 0.0002321665 3.660896e-01 5.104273e-01 2 161231186 161231551 366 + 2.085 2.125 0.136
ENSG00000136560 E041 0.2966881 0.0272738961 9.227110e-01   2 161232733 161232755 23 + 0.128 0.000 -11.369
ENSG00000136560 E042 0.4439371 0.0215626717 5.243503e-01 6.578974e-01 2 161232756 161232794 39 + 0.180 0.000 -11.949
ENSG00000136560 E043 0.8921407 0.0132954480 1.736866e-01 2.929810e-01 2 161232795 161232809 15 + 0.307 0.000 -12.891
ENSG00000136560 E044 1.0373134 0.0122230016 1.258314e-01 2.283326e-01 2 161232810 161232897 88 + 0.342 0.000 -13.088
ENSG00000136560 E045 131.4704423 0.0037146546 1.535568e-12 3.649131e-11 2 161235342 161236230 889 + 1.966 2.260 0.985