ENSG00000136536

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000259050 ENSG00000136536 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF7 protein_coding protein_coding 17.40258 2.430346 31.17569 0.1596058 0.7994899 3.675726 5.53355540 1.65076668 8.64926756 0.33812497 0.93564515 2.382396 0.45717500 0.694466667 0.279266667 -0.41520000 1.218903e-01 6.827311e-07 FALSE TRUE
ENST00000473749 ENSG00000136536 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF7 protein_coding processed_transcript 17.40258 2.430346 31.17569 0.1596058 0.7994899 3.675726 2.16680573 0.00000000 4.51312449 0.00000000 1.03344581 8.821176 0.07972500 0.000000000 0.145433333 0.14543333 2.284739e-05 6.827311e-07 FALSE FALSE
ENST00000478396 ENSG00000136536 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF7 protein_coding processed_transcript 17.40258 2.430346 31.17569 0.1596058 0.7994899 3.675726 0.06677262 0.23119547 0.05917613 0.17638764 0.02209436 -1.801857 0.01499167 0.086800000 0.001933333 -0.08486667 3.605621e-02 6.827311e-07 FALSE FALSE
MSTRG.19392.2 ENSG00000136536 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF7 protein_coding   17.40258 2.430346 31.17569 0.1596058 0.7994899 3.675726 2.09514125 0.01428072 5.09923199 0.01428072 0.71732263 7.717152 0.06597500 0.005233333 0.162833333 0.15760000 6.827311e-07 6.827311e-07 FALSE FALSE
MSTRG.19392.3 ENSG00000136536 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF7 protein_coding   17.40258 2.430346 31.17569 0.1596058 0.7994899 3.675726 2.43005899 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.08560833 0.000000000 0.000000000 0.00000000   6.827311e-07 FALSE FALSE
MSTRG.19392.4 ENSG00000136536 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF7 protein_coding   17.40258 2.430346 31.17569 0.1596058 0.7994899 3.675726 2.92697932 0.33010235 6.54560967 0.17052845 1.35027408 4.268689 0.18919583 0.133733333 0.208166667 0.07443333 7.017173e-01 6.827311e-07 FALSE TRUE
MSTRG.19392.6 ENSG00000136536 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF7 protein_coding   17.40258 2.430346 31.17569 0.1596058 0.7994899 3.675726 1.32300498 0.04110910 5.19906681 0.04110910 1.21797232 6.671301 0.05276667 0.018800000 0.165200000 0.14640000 2.790278e-02 6.827311e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136536 E001 1.6586885 0.0082384580 8.423896e-01 9.017912e-01 2 159712457 159712479 23 + 0.296 0.319 0.148
ENSG00000136536 E002 1.5113257 0.0232472209 9.426147e-01 9.679662e-01 2 159712480 159712498 19 + 0.274 0.319 0.301
ENSG00000136536 E003 1.3296214 0.0229073869 3.236060e-01 4.669062e-01 2 159712499 159712500 2 + 0.274 0.000 -10.509
ENSG00000136536 E004 6.0550717 0.0028236418 3.585657e-03 1.197054e-02 2 159712501 159712505 5 + 0.700 0.000 -12.618
ENSG00000136536 E005 6.0571481 0.0039494092 3.641153e-03 1.213016e-02 2 159712506 159712506 1 + 0.700 0.000 -12.616
ENSG00000136536 E006 15.6208531 0.0022910818 3.035356e-04 1.393688e-03 2 159712507 159712522 16 + 1.044 0.501 -2.216
ENSG00000136536 E007 45.6447353 0.0019023556 7.211370e-06 4.949900e-05 2 159712523 159712606 84 + 1.475 1.146 -1.150
ENSG00000136536 E008 27.7981856 0.0013670424 1.533306e-05 9.763713e-05 2 159712607 159712661 55 + 1.276 0.807 -1.724
ENSG00000136536 E009 7.9687318 0.0023395421 8.817280e-03 2.582691e-02 2 159714557 159714598 42 + 0.791 0.319 -2.258
ENSG00000136536 E010 2.6958881 0.0054917979 4.158371e-01 5.591770e-01 2 159715533 159715631 99 + 0.425 0.319 -0.617
ENSG00000136536 E011 3.4041463 0.0045370774 7.012587e-01 8.004951e-01 2 159715681 159715766 86 + 0.485 0.500 0.077
ENSG00000136536 E012 109.6547459 0.0003208858 1.283907e-08 1.551425e-07 2 159729009 159729175 167 + 1.838 1.625 -0.723
ENSG00000136536 E013 0.2987644 0.0275345143 1.000000e+00   2 159733965 159734082 118 + 0.078 0.000 -8.356
ENSG00000136536 E014 163.3242872 0.0002182778 9.647807e-12 2.016269e-10 2 159743061 159743253 193 + 2.008 1.805 -0.681
ENSG00000136536 E015 153.8320021 0.0007313544 1.582299e-08 1.879149e-07 2 159745770 159745937 168 + 1.979 1.827 -0.512
ENSG00000136536 E016 258.2067623 0.0001927967 3.656441e-10 5.867867e-09 2 159747805 159748200 396 + 2.197 2.106 -0.303
ENSG00000136536 E017 375.2445468 0.0001602874 3.004661e-05 1.787793e-04 2 159748201 159748903 703 + 2.348 2.373 0.083
ENSG00000136536 E018 104.7961372 0.0003257127 5.919390e-01 7.145838e-01 2 159752402 159752489 88 + 1.781 1.948 0.562
ENSG00000136536 E019 123.2095165 0.0008110622 7.195608e-01 8.143558e-01 2 159752490 159752571 82 + 1.857 1.979 0.410
ENSG00000136536 E020 107.2465558 0.0009010161 7.301836e-02 1.483634e-01 2 159759226 159759291 66 + 1.807 1.847 0.136
ENSG00000136536 E021 86.7457099 0.0003119041 1.005146e-01 1.912308e-01 2 159759292 159759335 44 + 1.717 1.758 0.140
ENSG00000136536 E022 2.4495500 0.0075007055 5.098809e-01 6.451641e-01 2 159759336 159759358 23 + 0.392 0.319 -0.436
ENSG00000136536 E023 145.2022501 0.0002832242 4.013927e-01 5.450890e-01 2 159762880 159762993 114 + 1.931 2.034 0.346
ENSG00000136536 E024 111.7375715 0.0002473850 3.110823e-01 4.535304e-01 2 159764626 159764674 49 + 1.821 1.909 0.298
ENSG00000136536 E025 505.4610812 0.0230992756 5.870726e-11 1.076131e-09 2 159767284 159771027 3744 + 2.392 2.910 1.727