ENSG00000136492

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000577598 ENSG00000136492 HEK293_OSMI2_2hA HEK293_TMG_2hB BRIP1 protein_coding protein_coding 8.452111 2.172965 15.83176 0.2646902 0.2054378 2.859372 0.8582411 0.05266982 1.21295713 0.02709610 0.13462200 4.286459 0.08913333 0.02393333 0.076466667 0.05253333 6.223254e-02 9.479903e-10 FALSE TRUE
ENST00000584322 ENSG00000136492 HEK293_OSMI2_2hA HEK293_TMG_2hB BRIP1 protein_coding protein_coding 8.452111 2.172965 15.83176 0.2646902 0.2054378 2.859372 0.2448109 0.14432826 0.32883637 0.07940331 0.23989258 1.134586 0.03732083 0.07590000 0.021066667 -0.05483333 6.246618e-01 9.479903e-10 FALSE TRUE
ENST00000682453 ENSG00000136492 HEK293_OSMI2_2hA HEK293_TMG_2hB BRIP1 protein_coding protein_coding 8.452111 2.172965 15.83176 0.2646902 0.2054378 2.859372 1.6593953 0.65673365 3.68975786 0.08716977 0.20217486 2.472248 0.20571667 0.31250000 0.232833333 -0.07966667 4.997233e-01 9.479903e-10 FALSE TRUE
ENST00000683235 ENSG00000136492 HEK293_OSMI2_2hA HEK293_TMG_2hB BRIP1 protein_coding nonsense_mediated_decay 8.452111 2.172965 15.83176 0.2646902 0.2054378 2.859372 0.8825283 0.07463317 0.93894579 0.07463317 0.30280898 3.487031 0.09458750 0.02763333 0.059033333 0.03140000 5.390389e-01 9.479903e-10 TRUE TRUE
ENST00000683535 ENSG00000136492 HEK293_OSMI2_2hA HEK293_TMG_2hB BRIP1 protein_coding processed_transcript 8.452111 2.172965 15.83176 0.2646902 0.2054378 2.859372 0.2284991 0.60026904 0.04738535 0.14446688 0.04738535 -3.410691 0.10253333 0.27696667 0.002933333 -0.27403333 1.313205e-06 9.479903e-10 FALSE TRUE
MSTRG.14846.10 ENSG00000136492 HEK293_OSMI2_2hA HEK293_TMG_2hB BRIP1 protein_coding   8.452111 2.172965 15.83176 0.2646902 0.2054378 2.859372 1.5703465 0.00000000 3.91453362 0.00000000 0.52205995 8.616377 0.13466250 0.00000000 0.247633333 0.24763333 9.479903e-10 9.479903e-10 FALSE TRUE
MSTRG.14846.11 ENSG00000136492 HEK293_OSMI2_2hA HEK293_TMG_2hB BRIP1 protein_coding   8.452111 2.172965 15.83176 0.2646902 0.2054378 2.859372 0.3751793 0.00000000 0.83772553 0.00000000 0.83772553 6.405525 0.02455417 0.00000000 0.052900000 0.05290000 1.000000e+00 9.479903e-10 FALSE TRUE
MSTRG.14846.19 ENSG00000136492 HEK293_OSMI2_2hA HEK293_TMG_2hB BRIP1 protein_coding   8.452111 2.172965 15.83176 0.2646902 0.2054378 2.859372 0.7760401 0.09637435 1.32890826 0.04826251 0.06212362 3.653835 0.06220000 0.04313333 0.083900000 0.04076667 2.953239e-01 9.479903e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136492 E001 3.8342507 0.0078883665 5.295705e-01 6.623416e-01 17 61679139 61681265 2127 - 0.532 0.673 0.627
ENSG00000136492 E002 0.4417591 0.1573134190 3.502421e-02 8.169657e-02 17 61681266 61681271 6 - 0.047 0.451 3.996
ENSG00000136492 E003 0.4417591 0.1573134190 3.502421e-02 8.169657e-02 17 61681272 61681273 2 - 0.047 0.451 3.996
ENSG00000136492 E004 0.4417591 0.1573134190 3.502421e-02 8.169657e-02 17 61681274 61681278 5 - 0.047 0.451 3.996
ENSG00000136492 E005 0.4417591 0.1573134190 3.502421e-02 8.169657e-02 17 61681279 61681285 7 - 0.047 0.451 3.996
ENSG00000136492 E006 15.7552807 0.0818129052 2.057731e-05 1.272793e-04 17 61681286 61681348 63 - 0.870 1.608 2.625
ENSG00000136492 E007 20.8931484 0.0513584747 1.503026e-07 1.475279e-06 17 61681349 61681388 40 - 0.981 1.721 2.590
ENSG00000136492 E008 50.9892664 0.0356429197 4.055171e-07 3.651678e-06 17 61681389 61681479 91 - 1.420 1.989 1.934
ENSG00000136492 E009 455.4711228 0.0001924918 1.491905e-18 8.047747e-17 17 61681480 61684140 2661 - 2.452 2.658 0.686
ENSG00000136492 E010 8.4903655 0.0024856952 4.468709e-03 1.445348e-02 17 61684772 61685214 443 - 0.869 0.285 -2.789
ENSG00000136492 E011 2.3859629 0.0582162853 1.072083e-01 2.014070e-01 17 61685215 61685218 4 - 0.452 0.000 -13.202
ENSG00000136492 E012 2.5311356 0.0161465020 8.097169e-02 1.610567e-01 17 61685219 61685230 12 - 0.469 0.000 -13.526
ENSG00000136492 E013 20.3001095 0.0042969507 1.047787e-01 1.977778e-01 17 61685231 61685835 605 - 1.133 1.330 0.696
ENSG00000136492 E014 90.8713763 0.0029328824 1.557651e-01 2.694489e-01 17 61685836 61686165 330 - 1.797 1.740 -0.193
ENSG00000136492 E015 0.2924217 0.0273114772 1.000000e+00   17 61687113 61687237 125 - 0.089 0.000 -10.623
ENSG00000136492 E016 0.5911862 0.0172671820 1.000000e+00 1.000000e+00 17 61688356 61688472 117 - 0.164 0.000 -11.677
ENSG00000136492 E017 55.2088181 0.0049624863 7.221116e-02 1.470213e-01 17 61693430 61693512 83 - 1.592 1.475 -0.401
ENSG00000136492 E018 61.7712847 0.0013569301 4.598455e-02 1.020062e-01 17 61715951 61716063 113 - 1.639 1.525 -0.389
ENSG00000136492 E019 0.1515154 0.0428028690 7.338241e-01   17 61716064 61716771 708 - 0.047 0.000 -9.521
ENSG00000136492 E020 0.8877725 0.0154847384 1.667928e-01 2.840102e-01 17 61739057 61739116 60 - 0.164 0.455 2.016
ENSG00000136492 E021 4.6582540 0.1012770172 1.566192e-04 7.766474e-04 17 61739117 61739410 294 - 0.415 1.185 3.160
ENSG00000136492 E022 63.4434101 0.0005303046 6.376191e-02 1.329582e-01 17 61743013 61743134 122 - 1.616 1.760 0.486
ENSG00000136492 E023 64.6411141 0.0012222013 1.633648e-01 2.795562e-01 17 61744432 61744591 160 - 1.628 1.746 0.399
ENSG00000136492 E024 0.0000000       17 61758674 61759310 637 -      
ENSG00000136492 E025 0.0000000       17 61775878 61776147 270 -      
ENSG00000136492 E026 47.3937169 0.0005068286 6.380365e-01 7.517753e-01 17 61776401 61776502 102 - 1.517 1.512 -0.018
ENSG00000136492 E027 28.5053244 0.0013895401 9.995802e-01 1.000000e+00 17 61776503 61776562 60 - 1.300 1.330 0.103
ENSG00000136492 E028 1.1072432 0.0113074097 8.363156e-01 8.976424e-01 17 61776563 61776898 336 - 0.227 0.285 0.435
ENSG00000136492 E029 4.3831567 0.0085879447 1.139025e-01 2.112122e-01 17 61776899 61778119 1221 - 0.623 0.285 -1.788
ENSG00000136492 E030 2.8893345 0.0052910188 3.369776e-01 4.808379e-01 17 61778120 61778179 60 - 0.485 0.285 -1.151
ENSG00000136492 E031 4.8435626 0.0033240985 2.235494e-01 3.546323e-01 17 61778180 61778672 493 - 0.586 0.817 0.960
ENSG00000136492 E032 2.5258370 0.0059254693 4.179061e-01 5.612182e-01 17 61778673 61778778 106 - 0.452 0.285 -0.982
ENSG00000136492 E033 3.6361887 0.0055792844 1.951502e-01 3.201806e-01 17 61778779 61780260 1482 - 0.560 0.285 -1.505
ENSG00000136492 E034 44.6624497 0.0005838781 2.032923e-03 7.328712e-03 17 61780261 61780401 141 - 1.516 1.270 -0.852
ENSG00000136492 E035 2.7207640 0.0479898340 1.984129e-01 3.242278e-01 17 61780402 61780839 438 - 0.395 0.675 1.331
ENSG00000136492 E036 69.9360330 0.0022354615 1.696800e-02 4.486568e-02 17 61780840 61781005 166 - 1.696 1.559 -0.468
ENSG00000136492 E037 0.1515154 0.0428028690 7.338241e-01   17 61783819 61783907 89 - 0.047 0.000 -9.521
ENSG00000136492 E038 67.9895376 0.0004155272 1.414970e-01 2.500671e-01 17 61784270 61784424 155 - 1.677 1.611 -0.224
ENSG00000136492 E039 0.8062886 0.0216326527 5.796031e-01 7.044569e-01 17 61784425 61784637 213 - 0.163 0.285 1.021
ENSG00000136492 E040 48.6466515 0.0005570076 3.023404e-01 4.442078e-01 17 61793597 61793729 133 - 1.535 1.486 -0.166
ENSG00000136492 E041 2.3547523 0.1675350573 3.592561e-01 5.035923e-01 17 61795732 61796540 809 - 0.377 0.579 1.015
ENSG00000136492 E042 63.1420560 0.0006554599 5.868998e-05 3.249544e-04 17 61799100 61799299 200 - 1.665 1.383 -0.966
ENSG00000136492 E043 73.9553439 0.0003763179 9.357378e-05 4.918095e-04 17 61801253 61801474 222 - 1.729 1.486 -0.827
ENSG00000136492 E044 0.4375944 0.0265704013 1.000000e+00 1.000000e+00 17 61801906 61801990 85 - 0.128 0.000 -11.190
ENSG00000136492 E045 89.8578122 0.0003349704 1.529930e-07 1.499279e-06 17 61808467 61808757 291 - 1.818 1.499 -1.081
ENSG00000136492 E046 0.1515154 0.0428028690 7.338241e-01   17 61844931 61844935 5 - 0.047 0.000 -9.521
ENSG00000136492 E047 5.0334799 0.0035372612 4.227324e-06 3.057161e-05 17 61844936 61845819 884 - 0.469 1.145 2.738
ENSG00000136492 E048 0.4375944 0.0265704013 1.000000e+00 1.000000e+00 17 61846882 61847100 219 - 0.128 0.000 -11.190
ENSG00000136492 E049 59.7869419 0.0003845744 8.921073e-06 6.000393e-05 17 61847101 61847220 120 - 1.644 1.311 -1.147
ENSG00000136492 E050 64.9831904 0.0003771163 4.983148e-04 2.153774e-03 17 61849129 61849256 128 - 1.672 1.445 -0.774
ENSG00000136492 E051 71.1829809 0.0175072935 3.724203e-03 1.236725e-02 17 61857058 61857231 174 - 1.711 1.466 -0.838
ENSG00000136492 E052 44.8676260 0.0005338899 1.646963e-04 8.122567e-04 17 61859796 61859907 112 - 1.522 1.199 -1.121
ENSG00000136492 E053 51.1813231 0.0004796467 5.391055e-06 3.809329e-05 17 61861447 61861565 119 - 1.583 1.199 -1.330
ENSG00000136492 E054 17.6751539 0.0052318442 8.795782e-02 1.720105e-01 17 61861566 61861569 4 - 1.129 0.925 -0.749
ENSG00000136492 E055 0.8984834 0.0629920425 5.478744e-01 6.778550e-01 17 61861570 61861909 340 - 0.227 0.000 -11.899
ENSG00000136492 E056 3.7396580 0.0047314830 1.749601e-01 2.946177e-01 17 61861910 61862075 166 - 0.573 0.285 -1.566
ENSG00000136492 E057 4.6083903 0.0033578872 8.898391e-02 1.735799e-01 17 61862076 61863280 1205 - 0.646 0.285 -1.888
ENSG00000136492 E058 35.3263248 0.0011345101 2.941357e-03 1.009166e-02 17 61863284 61863326 43 - 1.419 1.145 -0.962
ENSG00000136492 E059 39.8674003 0.0005049840 7.001136e-04 2.899557e-03 17 61863327 61863473 147 - 1.473 1.173 -1.046
ENSG00000136492 E060 11.0056926 0.0017384468 2.218722e-02 5.605973e-02 17 61863474 61863559 86 - 0.954 0.577 -1.525