ENSG00000136295

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258796 ENSG00000136295 HEK293_OSMI2_2hA HEK293_TMG_2hB TTYH3 protein_coding protein_coding 33.43385 49.48439 22.47575 4.483473 0.3204221 -1.138254 15.160433 19.2706949 11.739169 5.7180147 0.4965445 -0.7145983 0.44937083 0.37386667 0.5219333 0.14806667 4.374417e-01 9.20107e-13 FALSE TRUE
ENST00000403167 ENSG00000136295 HEK293_OSMI2_2hA HEK293_TMG_2hB TTYH3 protein_coding protein_coding 33.43385 49.48439 22.47575 4.483473 0.3204221 -1.138254 4.504894 10.2762791 2.173379 1.6604912 0.1366936 -2.2360866 0.13069583 0.21803333 0.0968000 -0.12123333 9.778901e-02 9.20107e-13 FALSE TRUE
ENST00000407643 ENSG00000136295 HEK293_OSMI2_2hA HEK293_TMG_2hB TTYH3 protein_coding protein_coding 33.43385 49.48439 22.47575 4.483473 0.3204221 -1.138254 8.309967 12.9911462 4.153340 2.3075426 0.3475069 -1.6428256 0.24132917 0.26393333 0.1852000 -0.07873333 3.939148e-01 9.20107e-13 FALSE TRUE
ENST00000477439 ENSG00000136295 HEK293_OSMI2_2hA HEK293_TMG_2hB TTYH3 protein_coding processed_transcript 33.43385 49.48439 22.47575 4.483473 0.3204221 -1.138254 1.455002 0.9832596 1.447203 0.1560131 0.1027329 0.5529594 0.05045833 0.01960000 0.0643000 0.04470000 1.491329e-08 9.20107e-13   FALSE
MSTRG.29402.1 ENSG00000136295 HEK293_OSMI2_2hA HEK293_TMG_2hB TTYH3 protein_coding   33.43385 49.48439 22.47575 4.483473 0.3204221 -1.138254 1.650562 1.5355579 2.250056 0.5361254 0.2085863 0.5482308 0.05327917 0.03333333 0.1002333 0.06690000 9.812712e-02 9.20107e-13 FALSE TRUE
MSTRG.29402.5 ENSG00000136295 HEK293_OSMI2_2hA HEK293_TMG_2hB TTYH3 protein_coding   33.43385 49.48439 22.47575 4.483473 0.3204221 -1.138254 1.338958 3.4149456 0.000000 0.5507568 0.0000000 -8.4199373 0.04279583 0.07126667 0.0000000 -0.07126667 9.201070e-13 9.20107e-13 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136295 E001 2.360706 0.0146671394 3.443678e-09 4.622322e-08 7 2631956 2631968 13 + 0.923 0.000 -17.151
ENSG00000136295 E002 4.684777 0.0048946267 2.353374e-13 6.350088e-12 7 2631969 2631985 17 + 1.157 0.164 -4.862
ENSG00000136295 E003 20.972226 0.1310130809 8.135337e-06 5.515963e-05 7 2631986 2632062 77 + 1.674 0.934 -2.604
ENSG00000136295 E004 43.329656 0.0261220983 2.848627e-06 2.142799e-05 7 2632063 2632121 59 + 1.823 1.459 -1.239
ENSG00000136295 E005 48.126672 0.0285713193 2.313626e-02 5.802964e-02 7 2632122 2632155 34 + 1.736 1.600 -0.464
ENSG00000136295 E006 127.775205 0.0048262498 5.379358e-04 2.301862e-03 7 2632156 2632278 123 + 2.125 2.033 -0.309
ENSG00000136295 E007 3.232372 0.0071781391 1.928940e-01 3.174026e-01 7 2645532 2645886 355 + 0.377 0.648 1.319
ENSG00000136295 E008 204.512754 0.0031754132 1.456005e-04 7.282407e-04 7 2646853 2647022 170 + 2.315 2.243 -0.242
ENSG00000136295 E009 190.627085 0.0044964525 6.249811e-05 3.437187e-04 7 2647142 2647253 112 + 2.301 2.206 -0.320
ENSG00000136295 E010 245.784072 0.0058923965 4.799963e-03 1.537395e-02 7 2647418 2647638 221 + 2.383 2.333 -0.166
ENSG00000136295 E011 10.331900 0.0244649432 2.112562e-06 1.634746e-05 7 2647703 2647955 253 + 1.308 0.785 -1.924
ENSG00000136295 E012 3.554044 0.0452179165 1.531775e-02 4.120967e-02 7 2647956 2647958 3 + 0.844 0.488 -1.528
ENSG00000136295 E013 153.427149 0.0064468771 6.950248e-02 1.425359e-01 7 2647959 2648054 96 + 2.158 2.139 -0.063
ENSG00000136295 E014 21.496434 0.0008498455 2.789357e-10 4.562951e-09 7 2648055 2648538 484 + 1.551 1.142 -1.425
ENSG00000136295 E015 175.224447 0.0002638994 2.391420e-03 8.433966e-03 7 2649567 2649639 73 + 2.219 2.192 -0.091
ENSG00000136295 E016 241.930818 0.0017582478 1.000504e-05 6.648979e-05 7 2649913 2649988 76 + 2.389 2.318 -0.237
ENSG00000136295 E017 212.794710 0.0023287728 1.539114e-03 5.763374e-03 7 2652187 2652242 56 + 2.312 2.271 -0.139
ENSG00000136295 E018 1.571828 0.2689182302 7.742796e-01 8.544837e-01 7 2652825 2652917 93 + 0.377 0.382 0.029
ENSG00000136295 E019 249.130715 0.0020307368 1.385868e-03 5.260755e-03 7 2652918 2653010 93 + 2.376 2.341 -0.117
ENSG00000136295 E020 205.331819 0.0016940400 1.682606e-02 4.454510e-02 7 2656092 2656184 93 + 2.277 2.264 -0.043
ENSG00000136295 E021 244.325905 0.0012877403 4.357574e-02 9.760222e-02 7 2656398 2656534 137 + 2.339 2.344 0.017
ENSG00000136295 E022 276.337088 0.0002093757 3.373916e-03 1.136175e-02 7 2658286 2658459 174 + 2.399 2.392 -0.023
ENSG00000136295 E023 195.693220 0.0006189718 4.543869e-02 1.010023e-01 7 2658940 2659015 76 + 2.241 2.245 0.013
ENSG00000136295 E024 6.802248 0.0044046345 7.563966e-01 8.414736e-01 7 2659940 2660040 101 + 0.845 0.858 0.051
ENSG00000136295 E025 660.629707 0.0001319749 2.504238e-01 3.864428e-01 7 2661668 2662325 658 + 2.713 2.794 0.267
ENSG00000136295 E026 161.292221 0.0042362205 1.588382e-03 5.921404e-03 7 2662326 2662395 70 + 2.011 2.217 0.691
ENSG00000136295 E027 2836.365389 0.0057763789 1.026787e-08 1.262963e-07 7 2662396 2664802 2407 + 3.259 3.461 0.672