ENSG00000136280

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258781 ENSG00000136280 HEK293_OSMI2_2hA HEK293_TMG_2hB CCM2 protein_coding protein_coding 28.01623 51.68144 17.13582 1.822408 0.6183121 -1.592068 18.349575 31.083928 11.731421 1.8951945 0.7580956 -1.4050258 0.67773333 0.6004000 0.68363333 0.08323333 0.171794054 0.005265846 FALSE TRUE
ENST00000541586 ENSG00000136280 HEK293_OSMI2_2hA HEK293_TMG_2hB CCM2 protein_coding protein_coding 28.01623 51.68144 17.13582 1.822408 0.6183121 -1.592068 4.696163 12.369549 1.592670 0.4804070 0.4424048 -2.9494095 0.13997500 0.2400667 0.09293333 -0.14713333 0.005265846 0.005265846 FALSE TRUE
ENST00000544363 ENSG00000136280 HEK293_OSMI2_2hA HEK293_TMG_2hB CCM2 protein_coding protein_coding 28.01623 51.68144 17.13582 1.822408 0.6183121 -1.592068 1.959642 3.598272 1.906829 0.1597661 0.2151365 -0.9125864 0.07179167 0.0700000 0.11240000 0.04240000 0.137873846 0.005265846 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136280 E001 8.1757536 0.0021156753 3.750402e-01 0.5194490327 7 44999475 44999857 383 + 0.761 0.890 0.504
ENSG00000136280 E002 0.1451727 0.0436299730 1.332556e-01   7 45000188 45000188 1 + 0.203 0.000 -10.334
ENSG00000136280 E003 0.4720498 0.2295320441 1.527393e-01 0.2653906694 7 45000189 45000200 12 + 0.340 0.071 -2.737
ENSG00000136280 E004 4.3311842 0.0754190830 6.557683e-02 0.1360074990 7 45000201 45000248 48 + 0.878 0.550 -1.363
ENSG00000136280 E005 28.2833700 0.0112620218 9.523263e-01 0.9741513496 7 45000249 45000299 51 + 1.351 1.364 0.046
ENSG00000136280 E006 61.1938921 0.0008221772 2.972251e-01 0.4385286881 7 45000300 45000363 64 + 1.637 1.702 0.221
ENSG00000136280 E007 0.0000000       7 45027015 45027025 11 +      
ENSG00000136280 E008 0.0000000       7 45027026 45027266 241 +      
ENSG00000136280 E009 0.0000000       7 45027267 45027633 367 +      
ENSG00000136280 E010 0.0000000       7 45027634 45027671 38 +      
ENSG00000136280 E011 0.0000000       7 45027672 45027700 29 +      
ENSG00000136280 E012 0.3666179 0.0300179227 3.742271e-01 0.5186414311 7 45027701 45027797 97 + 0.203 0.071 -1.742
ENSG00000136280 E013 0.0000000       7 45029444 45029509 66 +      
ENSG00000136280 E014 52.9497791 0.0043483449 3.570788e-01 0.5014975616 7 45038253 45038260 8 + 1.572 1.642 0.238
ENSG00000136280 E015 192.8053875 0.0018906068 2.423219e-04 0.0011429641 7 45038261 45038426 166 + 2.279 2.157 -0.405
ENSG00000136280 E016 0.4751703 0.0220899791 6.599839e-01 0.7686998904 7 45063093 45063215 123 + 0.203 0.132 -0.746
ENSG00000136280 E017 205.0415647 0.0005196527 5.638826e-02 0.1204051688 7 45063918 45064001 84 + 2.253 2.201 -0.174
ENSG00000136280 E018 310.7018760 0.0013827921 2.592429e-01 0.3966339091 7 45064463 45064602 140 + 2.413 2.387 -0.087
ENSG00000136280 E019 182.0052833 0.0012587716 8.874355e-01 0.9320486231 7 45064603 45064646 44 + 2.162 2.163 0.003
ENSG00000136280 E020 10.9243551 0.0054626919 1.526312e-01 0.2652507689 7 45067636 45068442 807 + 1.111 0.954 -0.576
ENSG00000136280 E021 174.4351122 0.0006471833 8.263213e-01 0.8907101307 7 45068443 45068493 51 + 2.132 2.146 0.044
ENSG00000136280 E022 219.1903634 0.0001940907 4.978248e-01 0.6343608745 7 45068494 45068579 86 + 2.222 2.247 0.085
ENSG00000136280 E023 324.1448413 0.0003636590 1.547865e-01 0.2681257700 7 45069826 45069961 136 + 2.376 2.417 0.138
ENSG00000136280 E024 1.8862729 0.0085194360 4.222719e-02 0.0951384860 7 45069962 45070093 132 + 0.660 0.315 -1.747
ENSG00000136280 E025 2.5861106 0.0058458682 1.897720e-02 0.0492840636 7 45070094 45070168 75 + 0.761 0.384 -1.746
ENSG00000136280 E026 3.0438791 0.0093433726 2.478435e-04 0.0011662207 7 45070169 45070388 220 + 0.911 0.351 -2.523
ENSG00000136280 E027 16.5608991 0.0010830575 2.045770e-03 0.0073673170 7 45070389 45071749 1361 + 1.351 1.080 -0.961
ENSG00000136280 E028 10.8556548 0.0015679681 6.240395e-01 0.7405006447 7 45071750 45071872 123 + 1.023 0.971 -0.190
ENSG00000136280 E029 8.6408853 0.0068183365 2.541513e-01 0.3907911684 7 45071873 45072337 465 + 0.997 0.859 -0.521
ENSG00000136280 E030 7.0084418 0.0024343496 2.128341e-02 0.0541836740 7 45072338 45072725 388 + 1.023 0.736 -1.100
ENSG00000136280 E031 252.4065054 0.0002581885 6.219855e-01 0.7388593867 7 45072726 45072783 58 + 2.307 2.300 -0.025
ENSG00000136280 E032 13.1513953 0.0482311727 2.236947e-01 0.3548141992 7 45072784 45073459 676 + 1.184 1.024 -0.578
ENSG00000136280 E033 273.9825661 0.0001658718 2.953821e-02 0.0710503515 7 45073460 45073571 112 + 2.288 2.351 0.210
ENSG00000136280 E034 49.4256430 0.0004717741 6.130171e-05 0.0003378844 7 45073572 45074269 698 + 1.769 1.554 -0.730
ENSG00000136280 E035 381.4059392 0.0014818416 1.951123e-01 0.3201249566 7 45074270 45074408 139 + 2.449 2.492 0.143
ENSG00000136280 E036 805.2477327 0.0025847325 4.280378e-02 0.0961893053 7 45075777 45076469 693 + 2.762 2.818 0.188