ENSG00000136261

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258761 ENSG00000136261 HEK293_OSMI2_2hA HEK293_TMG_2hB BZW2 protein_coding protein_coding 74.41465 81.03011 87.2018 12.16154 1.243392 0.1058871 54.623356 58.70322 64.449784 5.823740 0.5026034 0.1347141 0.73662500 0.73510000 0.73943333 0.004333333 1.000000e+00 1.027915e-10 FALSE  
ENST00000415365 ENSG00000136261 HEK293_OSMI2_2hA HEK293_TMG_2hB BZW2 protein_coding protein_coding 74.41465 81.03011 87.2018 12.16154 1.243392 0.1058871 3.267950 0.00000 7.557838 0.000000 3.3829600 9.5637374 0.03823333 0.00000000 0.08723333 0.087233333 1.027915e-10 1.027915e-10 FALSE  
ENST00000433922 ENSG00000136261 HEK293_OSMI2_2hA HEK293_TMG_2hB BZW2 protein_coding protein_coding 74.41465 81.03011 87.2018 12.16154 1.243392 0.1058871 8.370218 12.74064 7.472685 1.432637 4.0666284 -0.7689422 0.11801250 0.15923333 0.08460000 -0.074633333 7.195569e-01 1.027915e-10 FALSE  
ENST00000630952 ENSG00000136261 HEK293_OSMI2_2hA HEK293_TMG_2hB BZW2 protein_coding protein_coding 74.41465 81.03011 87.2018 12.16154 1.243392 0.1058871 3.976533 2.59265 5.578635 1.296512 1.1870433 1.1025149 0.05530417 0.03766667 0.06393333 0.026266667 7.628304e-01 1.027915e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136261 E001 0.1472490 0.0435398145 4.637946e-01   7 16646131 16646133 3 + 0.125 0.000 -10.322
ENSG00000136261 E002 0.4417471 0.7087228553 2.908117e-01 4.316070e-01 7 16646134 16646141 8 + 0.301 0.000 -11.910
ENSG00000136261 E003 8.7066753 0.0019443405 3.962599e-02 9.033724e-02 7 16646142 16646159 18 + 1.091 0.885 -0.764
ENSG00000136261 E004 26.7770091 0.0007287215 2.062187e-02 5.279108e-02 7 16646160 16646173 14 + 1.514 1.378 -0.469
ENSG00000136261 E005 35.6918914 0.0005961394 4.724309e-03 1.516172e-02 7 16646174 16646180 7 + 1.640 1.494 -0.499
ENSG00000136261 E006 55.7869561 0.0008401247 7.318718e-05 3.955127e-04 7 16646181 16646194 14 + 1.841 1.667 -0.589
ENSG00000136261 E007 216.0116973 0.0014305309 6.406776e-04 2.682842e-03 7 16646195 16646288 94 + 2.384 2.294 -0.302
ENSG00000136261 E008 34.8602761 0.0051527402 3.060193e-01 4.481705e-01 7 16646289 16646304 16 + 1.587 1.531 -0.192
ENSG00000136261 E009 0.1472490 0.0435398145 4.637946e-01   7 16661214 16661222 9 + 0.125 0.000 -10.327
ENSG00000136261 E010 0.2987644 0.0293934066 1.840645e-01   7 16661223 16661252 30 + 0.222 0.000 -11.327
ENSG00000136261 E011 0.0000000       7 16661272 16661312 41 +      
ENSG00000136261 E012 0.0000000       7 16662133 16662254 122 +      
ENSG00000136261 E013 301.0250777 0.0002436474 2.765223e-05 1.658470e-04 7 16665437 16665501 65 + 2.520 2.449 -0.239
ENSG00000136261 E014 676.5996519 0.0001433037 2.193426e-14 6.863676e-13 7 16674412 16674588 177 + 2.882 2.792 -0.298
ENSG00000136261 E015 632.0441981 0.0002141457 4.183172e-06 3.027889e-05 7 16681301 16681404 104 + 2.832 2.780 -0.175
ENSG00000136261 E016 527.9628243 0.0001111070 3.868701e-03 1.277365e-02 7 16682780 16682845 66 + 2.742 2.715 -0.090
ENSG00000136261 E017 291.1288284 0.0001579709 5.437656e-01 6.743216e-01 7 16685905 16685923 19 + 2.466 2.471 0.017
ENSG00000136261 E018 628.1589179 0.0001332279 7.435972e-02 1.505161e-01 7 16685924 16686040 117 + 2.806 2.798 -0.029
ENSG00000136261 E019 10.1878739 0.0051302320 5.449656e-13 1.394410e-11 7 16686041 16687554 1514 + 1.329 0.464 -3.414
ENSG00000136261 E020 1.8292295 0.3068639440 6.993570e-01 7.991437e-01 7 16688525 16688594 70 + 0.525 0.362 -0.856
ENSG00000136261 E021 337.3627685 0.0023129372 2.913780e-01 4.322414e-01 7 16689797 16689822 26 + 2.542 2.519 -0.076
ENSG00000136261 E022 552.2530630 0.0001191538 1.898082e-02 4.929211e-02 7 16689823 16689906 84 + 2.756 2.738 -0.060
ENSG00000136261 E023 799.0480250 0.0001025984 5.246219e-01 6.581077e-01 7 16694834 16695004 171 + 2.902 2.912 0.032
ENSG00000136261 E024 778.3722824 0.0001491543 9.000797e-03 2.628197e-02 7 16696915 16697061 147 + 2.867 2.919 0.174
ENSG00000136261 E025 720.3144636 0.0006288352 1.767952e-04 8.645001e-04 7 16698048 16698186 139 + 2.815 2.896 0.270
ENSG00000136261 E026 703.1304701 0.0005251973 2.957768e-07 2.740586e-06 7 16704547 16704669 123 + 2.791 2.892 0.335
ENSG00000136261 E027 1134.1048679 0.0022397965 1.032494e-08 1.269093e-07 7 16706060 16706523 464 + 2.968 3.112 0.478