ENSG00000136243

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258742 ENSG00000136243 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP42 protein_coding protein_coding 29.03101 16.82838 43.71879 1.633939 0.5802886 1.37683 13.145683 9.5056419 17.393299 0.2496344 0.50697368 0.8709879 0.46227083 0.57353333 0.39776667 -0.175766667 0.016861230 0.006525642 FALSE TRUE
ENST00000410002 ENSG00000136243 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP42 protein_coding protein_coding 29.03101 16.82838 43.71879 1.633939 0.5802886 1.37683 3.337410 0.5799009 5.278533 0.2899561 0.67569588 3.1643230 0.10212083 0.03660000 0.12043333 0.083833333 0.385802207 0.006525642 FALSE TRUE
ENST00000438012 ENSG00000136243 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP42 protein_coding nonsense_mediated_decay 29.03101 16.82838 43.71879 1.633939 0.5802886 1.37683 1.737914 1.3286885 3.139579 0.4515184 0.43720480 1.2343389 0.05654583 0.07533333 0.07156667 -0.003766667 1.000000000 0.006525642 FALSE TRUE
ENST00000477844 ENSG00000136243 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP42 protein_coding retained_intron 29.03101 16.82838 43.71879 1.633939 0.5802886 1.37683 1.818127 1.2971608 2.131769 0.1114552 0.04127065 0.7123663 0.07401250 0.07730000 0.04876667 -0.028533333 0.019401550 0.006525642 FALSE TRUE
ENST00000487595 ENSG00000136243 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP42 protein_coding processed_transcript 29.03101 16.82838 43.71879 1.633939 0.5802886 1.37683 1.456932 0.4789697 1.623808 0.2089460 0.27993155 1.7404215 0.05368333 0.02643333 0.03730000 0.010866667 0.730998190 0.006525642 FALSE TRUE
ENST00000497500 ENSG00000136243 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP42 protein_coding retained_intron 29.03101 16.82838 43.71879 1.633939 0.5802886 1.37683 4.241858 1.6240663 8.780153 0.2695559 0.71982406 2.4274217 0.13210833 0.09723333 0.20120000 0.103966667 0.006525642 0.006525642 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136243 E001 9.938457 0.0016769978 3.001711e-01 4.418223e-01 7 23181841 23182023 183 + 1.055 0.963 -0.339
ENSG00000136243 E002 20.913093 0.0009269808 1.956708e-01 3.208042e-01 7 23182024 23182037 14 + 1.354 1.274 -0.278
ENSG00000136243 E003 34.954487 0.0006126534 5.550318e-02 1.188446e-01 7 23182038 23182047 10 + 1.572 1.475 -0.332
ENSG00000136243 E004 36.606716 0.0005844502 7.734825e-02 1.552266e-01 7 23182048 23182048 1 + 1.587 1.502 -0.290
ENSG00000136243 E005 57.937693 0.0005163434 5.919801e-02 1.252598e-01 7 23182049 23182063 15 + 1.776 1.708 -0.232
ENSG00000136243 E006 57.995984 0.0005377868 4.218074e-02 9.505531e-02 7 23182064 23182065 2 + 1.780 1.704 -0.257
ENSG00000136243 E007 144.312581 0.0002240425 1.916793e-03 6.967337e-03 7 23182066 23182206 141 + 2.168 2.096 -0.241
ENSG00000136243 E008 7.067335 0.0028930877 6.017186e-01 7.228017e-01 7 23182207 23182489 283 + 0.905 0.861 -0.172
ENSG00000136243 E009 199.904336 0.0002311758 1.306036e-01 2.349956e-01 7 23185070 23185220 151 + 2.289 2.273 -0.051
ENSG00000136243 E010 147.782806 0.0056012721 8.844619e-01 9.301579e-01 7 23185221 23185298 78 + 2.148 2.159 0.038
ENSG00000136243 E011 102.737070 0.0003177675 1.540007e-01 2.671114e-01 7 23187052 23187072 21 + 2.006 1.977 -0.097
ENSG00000136243 E012 156.784037 0.0002731108 8.114209e-02 1.613262e-01 7 23187073 23187146 74 + 2.189 2.161 -0.093
ENSG00000136243 E013 32.334769 0.0006870750 1.123582e-11 2.321003e-10 7 23187147 23187392 246 + 1.623 1.131 -1.710
ENSG00000136243 E014 19.261876 0.0073257521 4.200041e-06 3.039170e-05 7 23188033 23188219 187 + 1.398 0.941 -1.634
ENSG00000136243 E015 69.934184 0.0003589291 2.964977e-02 7.128067e-02 7 23194403 23195838 1436 + 1.786 1.903 0.393
ENSG00000136243 E016 139.956653 0.0007142350 1.271738e-01 2.301952e-01 7 23195839 23195915 77 + 2.139 2.112 -0.089
ENSG00000136243 E017 12.891653 0.0079402602 5.309442e-01 6.634581e-01 7 23196379 23196679 301 + 1.139 1.098 -0.146
ENSG00000136243 E018 133.654267 0.0047598159 7.375096e-01 8.276455e-01 7 23196680 23196766 87 + 2.098 2.135 0.124
ENSG00000136243 E019 7.833754 0.0549492752 8.439064e-01 9.028325e-01 7 23197173 23197230 58 + 0.905 0.981 0.283
ENSG00000136243 E020 5.941037 0.0028307613 8.924538e-01 9.352763e-01 7 23197231 23197247 17 + 0.828 0.831 0.012
ENSG00000136243 E021 2.149753 0.0068878841 1.206031e-01 2.208273e-01 7 23197248 23197284 37 + 0.561 0.293 -1.454
ENSG00000136243 E022 2.919308 0.0137143852 2.811997e-01 4.210794e-01 7 23199424 23199457 34 + 0.634 0.466 -0.779
ENSG00000136243 E023 113.516849 0.0002478369 1.039171e-03 4.094621e-03 7 23199458 23199542 85 + 1.989 2.122 0.446
ENSG00000136243 E024 417.372817 0.0032743359 1.300766e-08 1.569994e-07 7 23200168 23201011 844 + 2.532 2.709 0.590