ENSG00000136161

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344532 ENSG00000136161 HEK293_OSMI2_2hA HEK293_TMG_2hB RCBTB2 protein_coding protein_coding 2.528061 1.304787 3.996953 0.1706352 0.1789774 1.607676 1.6408367 0.5300179 2.8441117 0.1918580 0.1328233 2.4019627 0.62841250 0.38490000 0.7147 0.32980000 0.04723991 0.04723991 FALSE TRUE
ENST00000430805 ENSG00000136161 HEK293_OSMI2_2hA HEK293_TMG_2hB RCBTB2 protein_coding protein_coding 2.528061 1.304787 3.996953 0.1706352 0.1789774 1.607676 0.2170706 0.1127430 0.2122913 0.1127430 0.1061820 0.8568107 0.06530833 0.06853333 0.0509 -0.01763333 0.92274577 0.04723991 FALSE TRUE
ENST00000544904 ENSG00000136161 HEK293_OSMI2_2hA HEK293_TMG_2hB RCBTB2 protein_coding protein_coding 2.528061 1.304787 3.996953 0.1706352 0.1789774 1.607676 0.6299088 0.6620261 0.9405501 0.1334547 0.1796738 0.5002454 0.28498333 0.54656667 0.2344 -0.31216667 0.21237206 0.04723991 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136161 E001 0.2924217 0.0274274232 0.6960526688   13 48488963 48488969 7 - 0.141 0.001 -8.116
ENSG00000136161 E002 76.6366912 0.0071517920 0.0004882895 0.002115367 13 48488970 48489896 927 - 1.791 1.977 0.626
ENSG00000136161 E003 30.0233759 0.0008021709 0.5709362545 0.697347994 13 48489897 48490251 355 - 1.439 1.489 0.172
ENSG00000136161 E004 0.0000000       13 48491652 48491715 64 -      
ENSG00000136161 E005 0.0000000       13 48492440 48492573 134 -      
ENSG00000136161 E006 18.6745794 0.0012031437 0.4147166410 0.558125891 13 48496191 48496321 131 - 1.228 1.308 0.280
ENSG00000136161 E007 19.5338025 0.0086933171 0.9054955398 0.943853102 13 48499621 48499760 140 - 1.266 1.285 0.064
ENSG00000136161 E008 23.4788065 0.0008947855 0.6474090206 0.759078933 13 48501742 48501868 127 - 1.337 1.384 0.163
ENSG00000136161 E009 25.6320880 0.0009152276 0.1931212727 0.317690975 13 48502724 48502914 191 - 1.352 1.457 0.362
ENSG00000136161 E010 21.6276010 0.0009449502 0.1461764066 0.256482590 13 48510629 48510771 143 - 1.279 1.403 0.430
ENSG00000136161 E011 21.8412842 0.0009214114 0.6863157487 0.788870821 13 48511770 48511877 108 - 1.309 1.353 0.153
ENSG00000136161 E012 18.3052986 0.0109416614 0.4349925717 0.577230535 13 48512016 48512122 107 - 1.270 1.201 -0.244
ENSG00000136161 E013 8.9283306 0.0019369039 0.1622788605 0.278086203 13 48512123 48512131 9 - 1.009 0.850 -0.600
ENSG00000136161 E014 9.2292851 0.0018530033 0.1238505684 0.225450829 13 48512132 48512174 43 - 1.025 0.850 -0.659
ENSG00000136161 E015 20.4571574 0.0031472085 0.0893013205 0.174076540 13 48512729 48512895 167 - 1.337 1.201 -0.476
ENSG00000136161 E016 15.0416273 0.0027642908 0.0274588840 0.066924870 13 48515205 48515294 90 - 1.228 1.016 -0.763
ENSG00000136161 E017 10.8682815 0.0015833545 0.0083113183 0.024570930 13 48515295 48515355 61 - 1.117 0.814 -1.131
ENSG00000136161 E018 20.6847714 0.0011085568 0.1636618044 0.279901400 13 48515586 48515741 156 - 1.333 1.230 -0.359
ENSG00000136161 E019 10.3312046 0.0017615783 0.0447001474 0.099649437 13 48521898 48521962 65 - 1.077 0.850 -0.848
ENSG00000136161 E020 10.4741992 0.0018978402 0.1409368269 0.249304927 13 48522308 48522403 96 - 1.070 0.913 -0.582
ENSG00000136161 E021 8.8821071 0.0181333692 0.1924095084 0.316799124 13 48524659 48524757 99 - 1.008 0.848 -0.606
ENSG00000136161 E022 0.0000000       13 48532661 48532752 92 -      
ENSG00000136161 E023 6.4172317 0.0114298023 0.1239101445 0.225544107 13 48533028 48533256 229 - 0.898 0.686 -0.841