ENSG00000136152

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000349995 ENSG00000136152 HEK293_OSMI2_2hA HEK293_TMG_2hB COG3 protein_coding protein_coding 14.7187 20.85365 17.24101 1.937592 0.6820817 -0.2743102 5.234645 1.915993 8.692345 0.1933219 0.3094567 2.175801 0.3689750 0.09513333 0.5044 0.4092667 4.587839e-17 4.587839e-17 FALSE TRUE
ENST00000476702 ENSG00000136152 HEK293_OSMI2_2hA HEK293_TMG_2hB COG3 protein_coding non_stop_decay 14.7187 20.85365 17.24101 1.937592 0.6820817 -0.2743102 5.226575 12.182889 4.686135 1.6382045 0.4015350 -1.376494 0.3345083 0.58066667 0.2712 -0.3094667 2.331077e-09 4.587839e-17   FALSE
ENST00000617325 ENSG00000136152 HEK293_OSMI2_2hA HEK293_TMG_2hB COG3 protein_coding processed_transcript 14.7187 20.85365 17.24101 1.937592 0.6820817 -0.2743102 3.028831 5.961562 2.434663 0.8027463 0.1654012 -1.288472 0.2056625 0.28683333 0.1419 -0.1449333 2.534855e-03 4.587839e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136152 E001 15.7065922 0.0011672984 5.583995e-10 8.675341e-09 13 45464898 45464938 41 + 0.920 1.514 2.113
ENSG00000136152 E002 63.8419357 0.0010801774 6.023534e-34 1.365001e-31 13 45464939 45465004 66 + 1.493 2.112 2.092
ENSG00000136152 E003 78.0280413 0.0070905209 8.715914e-25 9.349965e-23 13 45465005 45465063 59 + 1.573 2.201 2.117
ENSG00000136152 E004 118.5841261 0.0058783067 1.672167e-26 2.074571e-24 13 45465064 45465210 147 + 1.795 2.351 1.864
ENSG00000136152 E005 4.6415002 0.0041161450 4.034735e-05 2.323308e-04 13 45465285 45465440 156 + 0.438 1.055 2.571
ENSG00000136152 E006 18.1178714 0.0016250966 1.338655e-23 1.268021e-21 13 45465441 45465814 374 + 0.782 1.674 3.195
ENSG00000136152 E007 24.6180451 0.0027052789 9.766620e-31 1.732450e-28 13 45466517 45466624 108 + 0.892 1.812 3.234
ENSG00000136152 E008 37.4057328 0.0033443979 2.127702e-08 2.468684e-07 13 45476201 45476347 147 + 1.602 1.209 -1.359
ENSG00000136152 E009 28.2052025 0.0008966179 2.411009e-06 1.842585e-05 13 45479005 45479066 62 + 1.478 1.139 -1.187
ENSG00000136152 E010 31.2238566 0.0157928911 2.620796e-05 1.581255e-04 13 45480125 45480245 121 + 1.524 1.155 -1.286
ENSG00000136152 E011 16.4925915 0.0190585809 2.966801e-03 1.016405e-02 13 45480246 45480249 4 + 1.253 0.947 -1.107
ENSG00000136152 E012 22.9331956 0.0166453787 2.651023e-05 1.597571e-04 13 45480250 45480290 41 + 1.402 0.976 -1.516
ENSG00000136152 E013 27.5019694 0.0011006645 2.607391e-07 2.442698e-06 13 45481230 45481304 75 + 1.473 1.077 -1.392
ENSG00000136152 E014 29.7671549 0.0007191601 3.382301e-06 2.503642e-05 13 45482381 45482473 93 + 1.496 1.176 -1.115
ENSG00000136152 E015 32.5380781 0.0021450961 2.890382e-09 3.935985e-08 13 45483230 45483355 126 + 1.550 1.099 -1.578
ENSG00000136152 E016 25.2313194 0.0008635477 1.180276e-07 1.183067e-06 13 45486495 45486575 81 + 1.442 1.005 -1.546
ENSG00000136152 E017 21.8787911 0.0009097036 2.285391e-05 1.397729e-04 13 45490915 45490958 44 + 1.374 1.031 -1.218
ENSG00000136152 E018 26.1989229 0.0007110506 9.211822e-06 6.174469e-05 13 45491412 45491468 57 + 1.444 1.119 -1.141
ENSG00000136152 E019 26.1413088 0.0007246560 1.880961e-04 9.128326e-04 13 45491469 45491538 70 + 1.430 1.176 -0.891
ENSG00000136152 E020 29.5742758 0.0007877192 1.244928e-05 8.093337e-05 13 45492159 45492250 92 + 1.488 1.193 -1.028
ENSG00000136152 E021 40.5205493 0.0005399582 1.722913e-05 1.084496e-04 13 45493347 45493486 140 + 1.611 1.382 -0.787
ENSG00000136152 E022 0.5483223 0.0211823190 1.303065e-01 2.345859e-01 13 45493487 45493936 450 + 0.070 0.346 2.807
ENSG00000136152 E023 41.5277875 0.0005451468 2.973143e-06 2.226736e-05 13 45496152 45496312 161 + 1.626 1.371 -0.875
ENSG00000136152 E024 40.5450180 0.0005402907 6.980305e-09 8.857914e-08 13 45503244 45503349 106 + 1.628 1.270 -1.232
ENSG00000136152 E025 41.0725970 0.0005501467 2.534056e-06 1.927989e-05 13 45509692 45509816 125 + 1.621 1.360 -0.896
ENSG00000136152 E026 36.5345769 0.0021886142 8.699826e-05 4.609840e-04 13 45511765 45511854 90 + 1.567 1.336 -0.794
ENSG00000136152 E027 0.9106883 0.3495799644 5.777377e-01 7.029531e-01 13 45511855 45511998 144 + 0.228 0.342 0.794
ENSG00000136152 E028 20.4160748 0.0009018934 3.866116e-04 1.722945e-03 13 45516143 45516146 4 + 1.333 1.055 -0.991
ENSG00000136152 E029 39.3107049 0.0007054315 3.303629e-05 1.944927e-04 13 45516147 45516263 117 + 1.596 1.371 -0.774
ENSG00000136152 E030 36.3863373 0.0006057798 4.959602e-05 2.797373e-04 13 45518762 45518850 89 + 1.565 1.336 -0.787
ENSG00000136152 E031 37.8452116 0.0005442757 5.212611e-06 3.693849e-05 13 45518960 45519094 135 + 1.587 1.324 -0.906
ENSG00000136152 E032 34.6513388 0.0051779909 2.627671e-05 1.584758e-04 13 45524976 45525051 76 + 1.556 1.270 -0.990
ENSG00000136152 E033 40.6132856 0.0063633431 5.285277e-03 1.670833e-02 13 45529791 45529918 128 + 1.596 1.444 -0.520
ENSG00000136152 E034 36.3150721 0.0027839191 2.249883e-02 5.671921e-02 13 45530682 45530780 99 + 1.537 1.434 -0.352
ENSG00000136152 E035 3.5806644 0.0045073884 7.214540e-01 8.158293e-01 13 45531151 45531309 159 + 0.616 0.607 -0.043
ENSG00000136152 E036 2.9787569 0.0091005017 6.041360e-01 7.247681e-01 13 45532010 45532109 100 + 0.578 0.535 -0.197
ENSG00000136152 E037 278.4637689 0.0136527489 2.737721e-01 4.128647e-01 13 45534702 45536701 2000 + 2.353 2.480 0.423