ENSG00000136143

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000434484 ENSG00000136143 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCLA2 protein_coding protein_coding 38.08764 29.55152 48.73483 1.994462 1.722896 0.7215289 1.734997 0.1469821 2.687166 0.14698212 0.1173304 4.102772 0.03630000 0.004933333 0.05530000 0.05036667 3.126403e-02 5.170679e-17 FALSE FALSE
ENST00000646932 ENSG00000136143 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCLA2 protein_coding protein_coding 38.08764 29.55152 48.73483 1.994462 1.722896 0.7215289 19.659676 6.3444104 30.635568 0.92151539 1.3555623 2.269848 0.45152083 0.216366667 0.62860000 0.41223333 2.512177e-10 5.170679e-17 FALSE TRUE
MSTRG.8727.27 ENSG00000136143 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCLA2 protein_coding   38.08764 29.55152 48.73483 1.994462 1.722896 0.7215289 2.578098 5.1999894 1.219609 0.83569673 0.3681923 -2.083081 0.08832917 0.173866667 0.02556667 -0.14830000 1.362903e-06 5.170679e-17   FALSE
MSTRG.8727.28 ENSG00000136143 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCLA2 protein_coding   38.08764 29.55152 48.73483 1.994462 1.722896 0.7215289 3.240121 5.5994920 1.745292 0.37143025 0.2345724 -1.676159 0.10950833 0.190533333 0.03573333 -0.15480000 5.170679e-17 5.170679e-17   FALSE
MSTRG.8727.29 ENSG00000136143 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCLA2 protein_coding   38.08764 29.55152 48.73483 1.994462 1.722896 0.7215289 2.761340 5.1885512 1.947851 0.67246197 0.1774160 -1.408838 0.09269583 0.174133333 0.04010000 -0.13403333 3.412405e-16 5.170679e-17   FALSE
MSTRG.8727.30 ENSG00000136143 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCLA2 protein_coding   38.08764 29.55152 48.73483 1.994462 1.722896 0.7215289 2.756120 5.0065635 1.619395 0.45518372 0.4706376 -1.622363 0.09708750 0.169033333 0.03376667 -0.13526667 7.124086e-05 5.170679e-17   FALSE
MSTRG.8727.7 ENSG00000136143 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCLA2 protein_coding   38.08764 29.55152 48.73483 1.994462 1.722896 0.7215289 1.830785 0.1333358 2.731974 0.06747198 0.2444404 4.257745 0.03880417 0.004633333 0.05586667 0.05123333 2.351943e-08 5.170679e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136143 E001 0.9286724 0.0156450289 5.738124e-01 6.997295e-01 13 47745736 47746437 702 - 0.281 0.199 -0.648
ENSG00000136143 E002 2.0808557 0.0073620320 6.500944e-03 1.992533e-02 13 47746438 47747424 987 - 0.550 0.000 -13.327
ENSG00000136143 E003 0.4449813 0.0213897835 7.878216e-01 8.640879e-01 13 47797002 47797212 211 - 0.135 0.199 0.672
ENSG00000136143 E004 0.0000000       13 47798259 47798508 250 -      
ENSG00000136143 E005 0.5117906 0.1983725414 7.679275e-01 8.500452e-01 13 47807394 47807399 6 - 0.135 0.201 0.697
ENSG00000136143 E006 0.8062886 0.0224646976 7.448531e-01 8.330344e-01 13 47807400 47807499 100 - 0.238 0.199 -0.323
ENSG00000136143 E007 0.2214452 0.0383865158 1.694245e-01   13 47884692 47884761 70 - 0.000 0.199 11.472
ENSG00000136143 E008 1.0392760 0.3139354431 1.678436e-01 2.853863e-01 13 47905329 47905398 70 - 0.357 0.000 -11.622
ENSG00000136143 E009 1.1887151 0.0187762673 5.367516e-02 1.156824e-01 13 47907018 47907135 118 - 0.391 0.000 -12.563
ENSG00000136143 E010 0.0000000       13 47907331 47907452 122 -      
ENSG00000136143 E011 2.7492568 0.0361532553 6.776183e-01 7.822837e-01 13 47932694 47932783 90 - 0.551 0.521 -0.140
ENSG00000136143 E012 9.0923109 0.0019682551 3.058312e-01 4.479626e-01 13 47934915 47935821 907 - 0.909 1.081 0.636
ENSG00000136143 E013 1.7433801 0.0196718551 5.244794e-01 6.579897e-01 13 47936491 47936501 11 - 0.422 0.335 -0.494
ENSG00000136143 E014 4.0985717 0.0038201942 3.295570e-01 4.730748e-01 13 47936502 47936617 116 - 0.700 0.592 -0.464
ENSG00000136143 E015 6.9237459 0.0025595482 6.615909e-01 7.700216e-01 13 47936618 47936773 156 - 0.823 0.932 0.420
ENSG00000136143 E016 0.5891098 0.0182635489 2.490430e-01 3.847852e-01 13 47939267 47939363 97 - 0.238 0.000 -11.616
ENSG00000136143 E017 0.2934659 0.0293104972 4.581532e-01   13 47942656 47942660 5 - 0.073 0.199 1.672
ENSG00000136143 E018 11.7663342 0.0086063002 3.272772e-02 7.725489e-02 13 47942661 47942688 28 - 0.964 1.251 1.037
ENSG00000136143 E019 33.4905783 0.0006123780 1.846712e-03 6.748284e-03 13 47942689 47942728 40 - 1.405 1.660 0.874
ENSG00000136143 E020 44.2844484 0.0005409462 1.966846e-04 9.496878e-04 13 47942729 47942780 52 - 1.519 1.784 0.901
ENSG00000136143 E021 279.2965510 0.0032037541 5.344615e-01 6.665095e-01 13 47942781 47943344 564 - 2.374 2.460 0.288
ENSG00000136143 E022 100.0741143 0.0003752550 3.245232e-02 7.672142e-02 13 47943345 47943360 16 - 1.961 1.937 -0.080
ENSG00000136143 E023 139.5732897 0.0002247337 1.369266e-02 3.752109e-02 13 47943361 47943445 85 - 2.105 2.084 -0.069
ENSG00000136143 E024 0.2998086 0.0295104719 4.587964e-01   13 47945731 47945939 209 - 0.073 0.199 1.671
ENSG00000136143 E025 161.4836188 0.0003741469 6.808929e-04 2.829107e-03 13 47948940 47949028 89 - 2.176 2.129 -0.156
ENSG00000136143 E026 186.3473770 0.0002788310 2.627274e-09 3.604121e-08 13 47949483 47949603 121 - 2.255 2.137 -0.396
ENSG00000136143 E027 83.5901706 0.0004483943 1.074318e-05 7.088049e-05 13 47954140 47954142 3 - 1.915 1.776 -0.469
ENSG00000136143 E028 189.7377505 0.0002294758 1.886531e-09 2.655257e-08 13 47954143 47954282 140 - 2.260 2.142 -0.394
ENSG00000136143 E029 0.8804994 0.1919937277 6.620788e-01 7.704392e-01 13 47954283 47954395 113 - 0.281 0.197 -0.660
ENSG00000136143 E030 130.4414954 0.0003534304 5.227188e-07 4.605717e-06 13 47954396 47954452 57 - 2.098 1.976 -0.408
ENSG00000136143 E031 163.6062526 0.0012657131 1.751332e-07 1.697542e-06 13 47954453 47954557 105 - 2.196 2.070 -0.423
ENSG00000136143 E032 1.5394358 0.0100014858 6.998015e-02 1.433386e-01 13 47956840 47956872 33 - 0.238 0.592 1.998
ENSG00000136143 E033 0.8438645 0.0143662493 1.207352e-01 2.210189e-01 13 47956873 47956878 6 - 0.135 0.438 2.260
ENSG00000136143 E034 3.6975315 0.0045429077 3.220592e-02 7.624736e-02 13 47965578 47965640 63 - 0.503 0.869 1.548
ENSG00000136143 E035 170.4316195 0.0018341500 4.262530e-09 5.621857e-08 13 47968595 47968733 139 - 2.223 2.065 -0.530
ENSG00000136143 E036 1.3920981 0.0356318688 4.991574e-04 2.156826e-03 13 47971453 47971680 228 - 0.073 0.705 4.482
ENSG00000136143 E037 4.8242633 0.0035206934 7.998835e-05 4.277885e-04 13 47971681 47971883 203 - 0.478 1.059 2.384
ENSG00000136143 E038 6.0915296 0.0027490637 1.275662e-02 3.534018e-02 13 47971884 47972086 203 - 0.667 1.037 1.440
ENSG00000136143 E039 163.5170820 0.0002129457 1.490601e-14 4.792768e-13 13 47973264 47973392 129 - 2.212 2.019 -0.646
ENSG00000136143 E040 10.8658369 0.0173296225 1.376484e-01 2.448069e-01 13 47987634 47988540 907 - 1.070 0.931 -0.514
ENSG00000136143 E041 204.2052333 0.0002233485 3.507657e-22 2.845889e-20 13 47988541 47988703 163 - 2.315 2.084 -0.772
ENSG00000136143 E042 174.1613553 0.0002006672 2.043061e-24 2.111575e-22 13 47988882 47988981 100 - 2.254 1.976 -0.932
ENSG00000136143 E043 1.1093195 0.0113746489 4.400642e-01 5.817824e-01 13 47991503 47991678 176 - 0.321 0.199 -0.910
ENSG00000136143 E044 0.6213751 0.0297644367 1.000000e+00 1.000000e+00 13 47992047 47992103 57 - 0.189 0.199 0.090
ENSG00000136143 E045 1.3263991 0.0742676863 2.869078e-01 4.273536e-01 13 47994800 47994896 97 - 0.390 0.198 -1.331
ENSG00000136143 E046 123.8625686 0.0028784599 2.406837e-14 7.482245e-13 13 47996843 47996912 70 - 2.112 1.809 -1.018
ENSG00000136143 E047 108.4558928 0.0039117348 1.830389e-11 3.649739e-10 13 47996913 47997023 111 - 2.054 1.763 -0.978
ENSG00000136143 E048 0.1515154 0.0433052001 1.000000e+00   13 48000907 48001179 273 - 0.073 0.000 -9.560
ENSG00000136143 E049 67.6084034 0.0069712296 6.898684e-06 4.758547e-05 13 48001180 48001323 144 - 1.844 1.606 -0.805
ENSG00000136143 E050 19.9974901 0.0009424001 1.939416e-36 5.241320e-34 13 48002248 48002259 12 - 0.649 1.754 4.011
ENSG00000136143 E051 83.9591553 0.0018654054 2.557696e-113 1.076773e-109 13 48002260 48002600 341 - 1.236 2.359 3.813
ENSG00000136143 E052 12.2261719 0.0022794392 1.950511e-14 6.155563e-13 13 48004478 48004700 223 - 0.667 1.479 2.998
ENSG00000136143 E053 63.9126597 0.0086187493 1.741741e-46 8.729303e-44 13 48004701 48005001 301 - 1.222 2.218 3.390
ENSG00000136143 E054 31.8300297 0.0123231365 1.544947e-25 1.787939e-23 13 48015171 48015248 78 - 0.972 1.908 3.252
ENSG00000136143 E055 179.8252972 0.0103195990 2.592555e-57 2.384232e-54 13 48037606 48037968 363 - 1.703 2.655 3.186