ENSG00000136111

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377625 ENSG00000136111 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D4 protein_coding protein_coding 21.46876 9.855945 30.44507 0.3238332 1.320882 1.626153 16.579063 9.3033301 22.209261 0.23676851 0.4924966 1.254442 0.8294250 0.94443333 0.73340000 -0.2110333 1.754930e-05 8.251522e-09 FALSE TRUE
ENST00000413735 ENSG00000136111 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D4 protein_coding protein_coding 21.46876 9.855945 30.44507 0.3238332 1.320882 1.626153 2.474999 0.0000000 4.674583 0.00000000 1.6764482 8.871777 0.0754875 0.00000000 0.14966667 0.1496667 8.251522e-09 8.251522e-09 FALSE FALSE
MSTRG.8883.5 ENSG00000136111 HEK293_OSMI2_2hA HEK293_TMG_2hB TBC1D4 protein_coding   21.46876 9.855945 30.44507 0.3238332 1.320882 1.626153 1.917289 0.1684282 2.893685 0.06235315 0.5388441 4.024469 0.0679875 0.01676667 0.09456667 0.0778000 8.542234e-04 8.251522e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136111 E001 7.4026284 0.0092580024 2.471898e-01 3.826148e-01 13 75283503 75284664 1162 - 0.796 1.039 0.920
ENSG00000136111 E002 102.4224522 0.0164303289 6.379885e-19 3.597173e-17 13 75284665 75284844 180 - 1.606 2.368 2.563
ENSG00000136111 E003 238.2695735 0.0204177182 3.990817e-09 5.294086e-08 13 75284845 75285020 176 - 2.105 2.648 1.813
ENSG00000136111 E004 1031.2563059 0.0074656014 2.735865e-14 8.431777e-13 13 75285021 75286615 1595 - 2.824 3.203 1.260
ENSG00000136111 E005 276.7510312 0.0002129045 4.642493e-01 6.039985e-01 13 75286616 75287025 410 - 2.353 2.481 0.427
ENSG00000136111 E006 189.0653534 0.0003989913 8.729502e-01 9.223432e-01 13 75288934 75289110 177 - 2.192 2.307 0.385
ENSG00000136111 E007 157.7319302 0.0049210701 2.366412e-01 3.702866e-01 13 75292102 75292254 153 - 2.133 2.188 0.182
ENSG00000136111 E008 69.1215014 0.0143896396 1.957309e-01 3.208749e-01 13 75292255 75292271 17 - 1.791 1.800 0.030
ENSG00000136111 E009 67.9276597 0.0141245342 3.890665e-02 8.901010e-02 13 75294854 75294864 11 - 1.800 1.748 -0.175
ENSG00000136111 E010 155.5293034 0.0007735146 5.970246e-04 2.522770e-03 13 75294865 75295013 149 - 2.144 2.138 -0.022
ENSG00000136111 E011 179.5346950 0.0002191840 4.850967e-04 2.103218e-03 13 75299330 75299574 245 - 2.203 2.211 0.026
ENSG00000136111 E012 153.5073153 0.0002335371 5.266660e-02 1.139026e-01 13 75302243 75302401 159 - 2.125 2.175 0.167
ENSG00000136111 E013 1.5982194 0.0157533733 4.527200e-01 5.935485e-01 13 75302616 75302821 206 - 0.320 0.523 1.104
ENSG00000136111 E014 167.0186107 0.0002417615 7.125617e-04 2.943595e-03 13 75306313 75306465 153 - 2.173 2.180 0.023
ENSG00000136111 E015 85.8437631 0.0022561028 1.348539e-02 3.704654e-02 13 75306466 75306471 6 - 1.890 1.880 -0.033
ENSG00000136111 E016 134.9205759 0.0003148430 4.111061e-06 2.981046e-05 13 75309942 75310034 93 - 2.095 2.045 -0.169
ENSG00000136111 E017 129.1027403 0.0011474982 4.016940e-07 3.620521e-06 13 75310035 75310151 117 - 2.086 1.999 -0.293
ENSG00000136111 E018 86.0491726 0.0086948853 5.897571e-02 1.248801e-01 13 75312738 75312781 44 - 1.893 1.883 -0.033
ENSG00000136111 E019 125.0470254 0.0113895501 3.311699e-02 7.803958e-02 13 75312782 75312898 117 - 2.057 2.030 -0.091
ENSG00000136111 E020 0.0000000       13 75316472 75316552 81 -      
ENSG00000136111 E021 0.0000000       13 75320014 75320037 24 -      
ENSG00000136111 E022 0.7362571 0.0530612591 6.103071e-01 7.296356e-01 13 75324237 75324401 165 - 0.188 0.335 1.097
ENSG00000136111 E023 195.1464375 0.0018422744 1.343823e-09 1.944571e-08 13 75326197 75326423 227 - 2.269 2.163 -0.354
ENSG00000136111 E024 102.1162062 0.0019331384 7.787510e-07 6.622320e-06 13 75327752 75327826 75 - 1.990 1.874 -0.391
ENSG00000136111 E025 128.3064203 0.0002484041 9.402875e-09 1.165879e-07 13 75336921 75337040 120 - 2.086 1.989 -0.325
ENSG00000136111 E026 125.4227717 0.0003180023 4.798731e-14 1.428288e-12 13 75341125 75341235 111 - 2.093 1.918 -0.588
ENSG00000136111 E027 124.0175300 0.0002858919 1.221072e-09 1.779586e-08 13 75341496 75341587 92 - 2.075 1.959 -0.387
ENSG00000136111 E028 131.6640896 0.0132662874 5.253577e-04 2.254378e-03 13 75349170 75349302 133 - 2.101 1.979 -0.411
ENSG00000136111 E029 100.3940420 0.0061424635 1.603625e-05 1.016706e-04 13 75356147 75356251 105 - 1.990 1.853 -0.461
ENSG00000136111 E030 96.1539651 0.0032503818 4.216901e-08 4.617532e-07 13 75359769 75359858 90 - 1.978 1.807 -0.576
ENSG00000136111 E031 255.4511394 0.0002156354 2.701186e-29 4.264430e-27 13 75362026 75362607 582 - 2.402 2.212 -0.636
ENSG00000136111 E032 0.0000000       13 75364601 75364655 55 -      
ENSG00000136111 E033 0.0000000       13 75366914 75367015 102 -      
ENSG00000136111 E034 186.2652982 0.0047905210 3.022187e-15 1.074797e-13 13 75481270 75482169 900 - 2.279 2.016 -0.878