ENSG00000136108

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258607 ENSG00000136108 HEK293_OSMI2_2hA HEK293_TMG_2hB CKAP2 protein_coding protein_coding 56.7506 16.23412 104.1261 0.6785869 2.704211 2.680481 34.352797 10.5933485 63.250650 1.00827761 0.9066409 2.576788 0.61205417 0.652466667 0.60780000 -0.04466667 7.504104e-01 2.415142e-05 FALSE  
ENST00000378034 ENSG00000136108 HEK293_OSMI2_2hA HEK293_TMG_2hB CKAP2 protein_coding protein_coding 56.7506 16.23412 104.1261 0.6785869 2.704211 2.680481 3.828414 0.7534548 6.682792 0.16627606 0.7803652 3.131994 0.07318333 0.046266667 0.06386667 0.01760000 5.004587e-01 2.415142e-05 FALSE  
ENST00000378037 ENSG00000136108 HEK293_OSMI2_2hA HEK293_TMG_2hB CKAP2 protein_coding protein_coding 56.7506 16.23412 104.1261 0.6785869 2.704211 2.680481 12.873406 3.3066539 25.152733 0.26997314 2.1533212 2.923488 0.22307500 0.205833333 0.24083333 0.03500000 6.448727e-01 2.415142e-05 FALSE  
ENST00000468284 ENSG00000136108 HEK293_OSMI2_2hA HEK293_TMG_2hB CKAP2 protein_coding protein_coding 56.7506 16.23412 104.1261 0.6785869 2.704211 2.680481 4.650989 0.1267676 7.987690 0.06205558 1.4898942 5.869785 0.05110833 0.007666667 0.07750000 0.06983333 2.415142e-05 2.415142e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136108 E001 0.7739347 0.0148850961 1.711540e-01 2.896840e-01 13 52454865 52455428 564 + 0.139 0.430 2.170
ENSG00000136108 E002 0.2998086 0.0293205089 2.037216e-01   13 52455429 52455438 10 + 0.051 0.266 2.753
ENSG00000136108 E003 8.3647596 0.0020662777 6.175233e-03 1.907484e-02 13 52455439 52455466 28 + 0.890 0.430 -1.999
ENSG00000136108 E004 16.9962563 0.0010565575 1.562750e-03 5.838492e-03 13 52455467 52455477 11 + 1.158 0.784 -1.401
ENSG00000136108 E005 269.3213420 0.0024712273 2.265398e-11 4.453849e-10 13 52455478 52455626 149 + 2.314 2.100 -0.716
ENSG00000136108 E006 0.0000000       13 52455972 52456007 36 +      
ENSG00000136108 E007 0.4482035 0.0267546919 1.000000e+00 1.000000e+00 13 52456008 52456179 172 + 0.139 0.000 -8.919
ENSG00000136108 E008 335.3154898 0.0003615789 5.092570e-22 4.070768e-20 13 52456523 52456607 85 + 2.412 2.171 -0.804
ENSG00000136108 E009 47.2388106 0.0016605942 1.950955e-04 9.428637e-04 13 52460896 52460898 3 + 1.573 1.328 -0.844
ENSG00000136108 E010 323.1725003 0.0002984066 5.492524e-14 1.620530e-12 13 52460899 52460974 76 + 2.388 2.222 -0.554
ENSG00000136108 E011 265.2648521 0.0001808489 3.822123e-12 8.520708e-11 13 52461058 52461108 51 + 2.303 2.137 -0.554
ENSG00000136108 E012 1468.2431184 0.0008613155 5.397673e-12 1.173099e-10 13 52461109 52461926 818 + 3.030 2.979 -0.167
ENSG00000136108 E013 527.5445472 0.0001423387 8.055846e-01 8.763972e-01 13 52462363 52462567 205 + 2.567 2.638 0.237
ENSG00000136108 E014 1.4601460 0.2814848372 3.072733e-01 4.494823e-01 13 52464751 52464782 32 + 0.351 0.000 -10.647
ENSG00000136108 E015 541.6352665 0.0003069128 8.630393e-01 9.156755e-01 13 52465295 52465465 171 + 2.579 2.648 0.231
ENSG00000136108 E016 24.7766913 0.0065785459 2.236945e-03 7.957310e-03 13 52465466 52465843 378 + 1.198 1.533 1.163
ENSG00000136108 E017 427.0859842 0.0001351053 4.284364e-01 5.712012e-01 13 52468278 52468347 70 + 2.473 2.557 0.280
ENSG00000136108 E018 6.3824587 0.0383968965 3.111130e-02 7.412018e-02 13 52473535 52473828 294 + 0.654 1.048 1.535
ENSG00000136108 E019 744.4079626 0.0001639004 2.956504e-02 7.110405e-02 13 52473829 52474084 256 + 2.710 2.814 0.345
ENSG00000136108 E020 1953.7991192 0.0094333278 1.463952e-06 1.173435e-05 13 52474895 52476628 1734 + 3.102 3.337 0.781