ENSG00000136068

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358537 ENSG00000136068 HEK293_OSMI2_2hA HEK293_TMG_2hB FLNB protein_coding protein_coding 46.98513 64.78653 29.90344 2.137772 0.9147063 -1.115123 16.299863 7.105931 19.104343 2.4378554 0.4550474 1.4255311 0.4220167 0.1106333 0.6392333 0.5286000 2.927450e-08 9.044041e-22 FALSE TRUE
ENST00000484981 ENSG00000136068 HEK293_OSMI2_2hA HEK293_TMG_2hB FLNB protein_coding processed_transcript 46.98513 64.78653 29.90344 2.137772 0.9147063 -1.115123 6.202513 20.095331 0.000000 3.9861317 0.0000000 -10.9733624 0.0973000 0.3094333 0.0000000 -0.3094333 9.044041e-22 9.044041e-22 FALSE TRUE
ENST00000682297 ENSG00000136068 HEK293_OSMI2_2hA HEK293_TMG_2hB FLNB protein_coding processed_transcript 46.98513 64.78653 29.90344 2.137772 0.9147063 -1.115123 14.382450 25.856510 3.175471 1.4106848 0.4731085 -3.0215068 0.2624000 0.3985333 0.1054667 -0.2930667 4.718905e-18 9.044041e-22 FALSE TRUE
MSTRG.23150.6 ENSG00000136068 HEK293_OSMI2_2hA HEK293_TMG_2hB FLNB protein_coding   46.98513 64.78653 29.90344 2.137772 0.9147063 -1.115123 1.630846 1.713385 2.949515 0.1742598 0.4828222 0.7801155 0.0405625 0.0265000 0.0979000 0.0714000 1.883438e-06 9.044041e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000136068 E001 0.7533107 0.3083109558 3.325604e-02 7.830394e-02 3 58008398 58008399 2 + 0.455 0.000 -23.818
ENSG00000136068 E002 2.1111584 0.0192537774 1.017376e-04 5.299097e-04 3 58008400 58008405 6 + 0.763 0.110 -4.059
ENSG00000136068 E003 9.2017321 0.0046331580 1.702359e-05 1.072663e-04 3 58008406 58008421 16 + 1.217 0.770 -1.663
ENSG00000136068 E004 38.8487871 0.0005414598 2.287345e-22 1.896414e-20 3 58008422 58008440 19 + 1.833 1.300 -1.822
ENSG00000136068 E005 70.3735434 0.0003745148 1.193512e-28 1.778971e-26 3 58008441 58008486 46 + 2.056 1.606 -1.517
ENSG00000136068 E006 206.0811270 0.0048432243 1.252788e-24 1.319271e-22 3 58008487 58008856 370 + 2.502 2.101 -1.339
ENSG00000136068 E007 178.9203967 0.0176449070 1.471408e-07 1.446869e-06 3 58077046 58077294 249 + 2.412 2.086 -1.090
ENSG00000136068 E008 0.1451727 0.0434859458 3.653190e-01   3 58078329 58078519 191 + 0.136 0.000 -21.736
ENSG00000136068 E009 125.1434613 0.0106990334 1.911205e-10 3.213848e-09 3 58078717 58078814 98 + 2.265 1.918 -1.162
ENSG00000136068 E010 163.6849040 0.0077561457 7.671068e-16 2.943396e-14 3 58081629 58081776 148 + 2.396 2.014 -1.277
ENSG00000136068 E011 156.0925230 0.0089612580 1.501400e-12 3.572864e-11 3 58094836 58094954 119 + 2.364 2.013 -1.174
ENSG00000136068 E012 120.4803018 0.0052030439 6.615969e-14 1.927973e-12 3 58096141 58096218 78 + 2.241 1.915 -1.093
ENSG00000136068 E013 172.6967164 0.0061420612 2.806663e-14 8.635926e-13 3 58097815 58097977 163 + 2.395 2.071 -1.081
ENSG00000136068 E014 207.9246930 0.0115523800 2.507520e-10 4.127930e-09 3 58098711 58098908 198 + 2.478 2.149 -1.100
ENSG00000136068 E015 0.1817044 0.0391757496 6.418761e-01   3 58099638 58099735 98 + 0.000 0.110 20.745
ENSG00000136068 E016 167.3095000 0.0141712115 3.315549e-07 3.039687e-06 3 58102203 58102340 138 + 2.367 2.078 -0.964
ENSG00000136068 E017 152.0543424 0.0067357202 2.694471e-09 3.691492e-08 3 58103959 58104085 127 + 2.311 2.051 -0.871
ENSG00000136068 E018 149.5014139 0.0100802941 1.432218e-07 1.412071e-06 3 58105080 58105216 137 + 2.306 2.043 -0.878
ENSG00000136068 E019 2.9474205 0.0052539642 6.349631e-03 1.953227e-02 3 58105217 58106354 1138 + 0.789 0.387 -1.844
ENSG00000136068 E020 181.5483715 0.0108397633 7.520779e-08 7.822923e-07 3 58106680 58106873 194 + 2.394 2.122 -0.909
ENSG00000136068 E021 2.4327053 0.2105050967 9.405955e-01 9.666865e-01 3 58106874 58108103 1230 + 0.454 0.538 0.412
ENSG00000136068 E022 138.3459421 0.0106049209 7.435784e-07 6.351445e-06 3 58108458 58108571 114 + 2.268 2.014 -0.847
ENSG00000136068 E023 184.8524097 0.0115276510 6.438861e-06 4.471327e-05 3 58109179 58109322 144 + 2.381 2.156 -0.752
ENSG00000136068 E024 177.0167686 0.0148681609 3.694816e-05 2.147153e-04 3 58109576 58109699 124 + 2.363 2.136 -0.760
ENSG00000136068 E025 186.1791084 0.0134925087 5.241965e-05 2.938612e-04 3 58110010 58110170 161 + 2.377 2.165 -0.710
ENSG00000136068 E026 1.3148701 0.0450439327 2.805185e-01 4.203717e-01 3 58110171 58111467 1297 + 0.453 0.271 -1.088
ENSG00000136068 E027 145.5794932 0.0079991925 1.987358e-07 1.905071e-06 3 58111791 58111881 91 + 2.282 2.044 -0.797
ENSG00000136068 E028 192.8353733 0.0084013665 3.065253e-06 2.288395e-05 3 58112149 58112318 170 + 2.388 2.185 -0.680
ENSG00000136068 E029 156.6084068 0.0133573977 3.852306e-04 1.717680e-03 3 58118872 58118989 118 + 2.289 2.105 -0.613
ENSG00000136068 E030 0.7363563 0.0361646151 4.800158e-01 6.183368e-01 3 58118990 58119487 498 + 0.136 0.271 1.231
ENSG00000136068 E031 255.9193723 0.0117195272 1.807039e-03 6.621415e-03 3 58121241 58121503 263 + 2.477 2.339 -0.459
ENSG00000136068 E032 444.3728499 0.0056396546 5.950344e-06 4.165373e-05 3 58123093 58123690 598 + 2.719 2.574 -0.482
ENSG00000136068 E033 222.4872717 0.0041243161 1.802954e-05 1.129885e-04 3 58124332 58124505 174 + 2.414 2.278 -0.452
ENSG00000136068 E034 219.9525016 0.0043026078 9.908597e-06 6.592751e-05 3 58125581 58125743 163 + 2.415 2.271 -0.481
ENSG00000136068 E035 217.7800195 0.0020868475 1.391229e-06 1.119834e-05 3 58126602 58126762 161 + 2.400 2.273 -0.423
ENSG00000136068 E036 165.2626520 0.0034201475 7.044752e-02 1.440856e-01 3 58130741 58130908 168 + 2.233 2.193 -0.135
ENSG00000136068 E037 17.4712259 0.0012234965 3.651330e-04 1.639218e-03 3 58130909 58131926 1018 + 1.397 1.135 -0.922
ENSG00000136068 E038 34.4003045 0.0015913761 1.942435e-02 5.025518e-02 3 58131927 58132019 93 + 1.603 1.486 -0.398
ENSG00000136068 E039 3.2795050 0.0130895532 5.070931e-01 6.427107e-01 3 58132020 58132077 58 + 0.671 0.588 -0.358
ENSG00000136068 E040 17.4393666 0.0054063638 1.459052e-07 1.435986e-06 3 58132078 58132807 730 + 1.468 1.032 -1.538
ENSG00000136068 E041 111.5661303 0.0037186210 6.579522e-02 1.363649e-01 3 58132808 58132836 29 + 2.070 2.018 -0.172
ENSG00000136068 E042 190.1987143 0.0002360285 2.212199e-04 1.054724e-03 3 58132837 58132931 95 + 2.310 2.240 -0.235
ENSG00000136068 E043 268.7192973 0.0001706000 3.201198e-07 2.944111e-06 3 58134616 58134772 157 + 2.469 2.383 -0.287
ENSG00000136068 E044 328.7971227 0.0001995739 3.830669e-06 2.798830e-05 3 58135979 58136168 190 + 2.545 2.479 -0.223
ENSG00000136068 E045 369.0398523 0.0004959424 2.977465e-01 4.390962e-01 3 58138282 58138529 248 + 2.552 2.558 0.021
ENSG00000136068 E046 8.9220169 0.0019982416 1.992943e-02 5.133896e-02 3 58138530 58141013 2484 + 1.107 0.882 -0.834
ENSG00000136068 E047 3.0172737 0.0052408691 6.586292e-01 7.676781e-01 3 58141158 58141857 700 + 0.635 0.588 -0.208
ENSG00000136068 E048 18.7959926 0.0010174051 4.926631e-09 6.438572e-08 3 58141858 58141896 39 + 0.861 1.434 2.062
ENSG00000136068 E049 12.2421011 0.0127434098 3.589291e-06 2.641214e-05 3 58141897 58141929 33 + 0.671 1.272 2.266
ENSG00000136068 E050 2.4220115 0.0073913849 1.764219e-01 2.965942e-01 3 58141930 58142649 720 + 0.635 0.435 -0.942
ENSG00000136068 E051 249.4822579 0.0001667936 9.199740e-01 9.534515e-01 3 58142650 58142752 103 + 2.367 2.397 0.099
ENSG00000136068 E052 310.3758244 0.0014351919 2.437748e-01 3.786126e-01 3 58143473 58143613 141 + 2.484 2.480 -0.013
ENSG00000136068 E053 2.0993227 0.0088254114 6.115771e-02 1.285778e-01 3 58144398 58145920 1523 + 0.240 0.588 1.964
ENSG00000136068 E054 305.9482989 0.0009649297 6.641965e-01 7.720487e-01 3 58145921 58146049 129 + 2.463 2.481 0.059
ENSG00000136068 E055 0.4031496 0.0244605094 2.960669e-01 4.372387e-01 3 58146678 58146819 142 + 0.000 0.198 21.748
ENSG00000136068 E056 354.7542162 0.0001825555 5.036103e-01 6.395947e-01 3 58146820 58146993 174 + 2.512 2.553 0.136
ENSG00000136068 E057 310.8418935 0.0003293199 5.003334e-01 6.365946e-01 3 58148206 58148364 159 + 2.454 2.496 0.141
ENSG00000136068 E058 413.1578987 0.0005406140 4.031843e-01 5.469692e-01 3 58148649 58148852 204 + 2.575 2.621 0.151
ENSG00000136068 E059 0.2214452 0.0398852774 6.404346e-01   3 58149088 58149231 144 + 0.000 0.110 20.749
ENSG00000136068 E060 0.5149242 0.1947448705 8.076699e-01 8.777978e-01 3 58149232 58149849 618 + 0.136 0.198 0.646
ENSG00000136068 E061 169.6950847 0.0006617811 1.119422e-02 3.163163e-02 3 58149850 58149865 16 + 2.150 2.256 0.352
ENSG00000136068 E062 325.7451613 0.0016969178 1.646298e-03 6.108710e-03 3 58149866 58149980 115 + 2.424 2.543 0.399
ENSG00000136068 E063 200.7692552 0.0003099143 1.916040e-04 9.279310e-04 3 58149981 58150002 22 + 2.208 2.336 0.429
ENSG00000136068 E064 313.1690718 0.0001707964 1.425492e-08 1.707805e-07 3 58150105 58150227 123 + 2.386 2.536 0.499
ENSG00000136068 E065 0.6589510 0.0189473782 4.790781e-01 6.174879e-01 3 58150228 58151391 1164 + 0.136 0.270 1.226
ENSG00000136068 E066 0.1482932 0.0421583814 6.422707e-01   3 58152708 58152807 100 + 0.000 0.109 20.741
ENSG00000136068 E067 0.1482932 0.0421583814 6.422707e-01   3 58152808 58152854 47 + 0.000 0.109 20.741
ENSG00000136068 E068 1.2103937 0.0105519280 1.127777e-01 2.095982e-01 3 58152855 58153374 520 + 0.136 0.435 2.227
ENSG00000136068 E069 435.8983289 0.0018113476 4.000894e-08 4.400333e-07 3 58153375 58153641 267 + 2.512 2.690 0.593
ENSG00000136068 E070 0.5964967 0.0248759837 1.910935e-01 3.151187e-01 3 58154610 58154790 181 + 0.323 0.110 -1.946
ENSG00000136068 E071 289.5602000 0.0032246093 5.438359e-08 5.814554e-07 3 58154791 58154928 138 + 2.304 2.525 0.738
ENSG00000136068 E072 268.3678341 0.0020151226 1.749868e-09 2.479116e-08 3 58155960 58156026 67 + 2.271 2.491 0.732
ENSG00000136068 E073 263.0589041 0.0012313548 5.582563e-09 7.224043e-08 3 58156027 58156075 49 + 2.280 2.475 0.649
ENSG00000136068 E074 415.5636117 0.0011638823 3.918332e-12 8.719796e-11 3 58159554 58159686 133 + 2.476 2.675 0.662
ENSG00000136068 E075 0.2955422 0.0296507376 8.208664e-01   3 58159687 58159691 5 + 0.136 0.110 -0.361
ENSG00000136068 E076 442.6952764 0.0012394760 3.334327e-22 2.713395e-20 3 58163154 58163330 177 + 2.453 2.723 0.898
ENSG00000136068 E077 2.5305744 0.0063070776 4.848614e-01 6.228001e-01 3 58163331 58163512 182 + 0.454 0.588 0.642
ENSG00000136068 E078 2.9807274 0.0057095348 8.574991e-01 9.120138e-01 3 58164573 58165475 903 + 0.596 0.588 -0.036
ENSG00000136068 E079 1.1812489 0.0107148756 1.130546e-01 2.099934e-01 3 58165476 58165580 105 + 0.136 0.435 2.225
ENSG00000136068 E080 15.2689328 0.0011857064 2.846652e-01 4.249252e-01 3 58165581 58168439 2859 + 1.119 1.240 0.431
ENSG00000136068 E081 636.2867330 0.0035778049 1.213702e-15 4.535151e-14 3 58168440 58168658 219 + 2.595 2.886 0.968
ENSG00000136068 E082 4.6072709 0.0357729757 4.779809e-01 6.164407e-01 3 58168659 58169589 931 + 0.635 0.774 0.577
ENSG00000136068 E083 621.1442249 0.0063020935 5.214094e-12 1.137226e-10 3 58169590 58169793 204 + 2.565 2.882 1.054
ENSG00000136068 E084 2259.8744807 0.0098627338 1.351199e-15 5.026127e-14 3 58170575 58172251 1677 + 3.074 3.457 1.273